BioLamina’s Post

New research identified neural biomarkers and associated neural activity for patients with severe OCD (obsessive-compulsive disorder) undergoing DBS therapy. Identification of this neuromarker laid down a big step in the advancement of technology for Deep Brain Stimulation. https://lnkd.in/gAZnixDR #OCD #obsessivecompulsivedisorder #dbstherapy #therapyforocd #deepbrainstimulation #news #study #research #psychologsnews

🚨 New Research Alert! 🚨 Our team at Thomas Jefferson University in collaboration with Duke University has developed an automated approach to programming Deep Brain Stimulators (DBS) for Parkinson’s Disease! Using "connectomic programming," this cutting-edge method optimizes DBS settings based on each patient's unique brain network, reducing programming time while achieving results that are comparable to traditional programming! This innovation lays the groundwork for future advancements in DBS programming, including the integration of machine learning and AI, to further personalize and enhance treatment. It’s a step toward faster, more accessible, and more effective therapy for #Parkinson’s Disease! Stay tuned as we continue to push the boundaries of #neuromodulation! #ParkinsonsResearch #DBS #AIinMedicine #Neuroscience #Connectomics #brainhealth https://lnkd.in/e5t4hw3P

#epilepsy #Ionchannel #neurodevelopment #integrin #KCNB1 Ion channels in neurodevelopment: lessons from the Integrin-KCNB1 channel complex https://lnkd.in/gFb9jDFT Rutgers Robert Wood Johnson Medical School Rutgers University Ion channels modulate cellular excitability by regulating ionic fluxes across biological membranes. Pathogenic mutations in ion channel genes give rise to epileptic disorders that are among the most frequent neurological diseases affecting millions of individuals worldwide. Epilepsies are triggered by an imbalance between excitatory and inhibitory conductances. However, pathogenic mutations in the same allele can give rise to loss-of-function and/or gain-of-function variants, all able to trigger epilepsy. Furthermore, certain alleles are associated with brain malformations even in the absence of a clear electrical phenotype. This body of evidence argues that the underlying epileptogenic mechanisms of ion channels are more diverse than originally thought. Studies focusing on ion channels in prenatal cortical development have shed light on this apparent paradox. The picture that emerges is that ion channels play crucial roles in landmark neurodevelopmental processes, including neuronal migration, neurite outgrowth, and synapse formation. Thus, pathogenic channel mutants can not only cause epileptic disorders by altering excitability, but further, by inducing morphological and synaptic abnormalities that are initiated during neocortex formation and may persist into the adult brain.

AI has so much potential for human development and a corollary. of potential issues. Such is the way of all emerging technologies.

In our Data in Biotech episode with Annemie Ribbens, VP of Science, Evidence, and Trials at icometrix, we focused on how AI can be used in the diagnosis and development of treatment for neurological disorders. She gave her expert take on: 💡 The role of AI in developing personalized medicine 💡 Measuring neurological disorder progression with biomarkers 💡 Managing issues around medical imaging data quality You can read the highlights of the episode and more on the topic in our latest blog here 👉 https://lnkd.in/e_-JyziX #Data #Biotech #Neurology #DataQuality #PersonalizedMedicine

In a feasibility study, authors show that adaptive deep brain stimulation (aDBS), which adjusts in #realtime to brain activity, could improve treatment for #Parkinsonsdisease (#PD) symptoms more effectively than conventional #DBS. Unlike traditional DBS, which provides constant stimulation, aDBS uses #machinelearning to modify stimulation based on real-time neural signals, reducing side effects and improving symptom control. In a study of four participants, aDBS improved their most bothersome symptoms by about 50% compared to conventional DBS. Even without being told which treatment they were receiving, most participants could distinguish aDBS due to symptom improvement. The system was tested at home in natural environments, alternating between aDBS and standard DBS. The study identified gamma oscillations in the brain as effective biomarkers to tailor stimulation, offering better symptom control by adjusting stimulation based on #dopamine levels influenced by #levodopa, a common PD medication. Despite the promise of aDBS, challenges remain in reducing the need for specialized clinical setup and increasing accessibility through automation. Further studies are needed to refine the system and assess its broader applicability. #closedloop #neurostimulation #deepbrainstimulation #biomarker #realtime #neurotech The National Institutes of Health Link: https://lnkd.in/eXwYZ4vs Link to clinical trial: https://lnkd.in/eRX4kUfV Link to NIH news: https://lnkd.in/eE_dZf6W

#neurodegeneration #neurodevelopment #kinesinsuperfamilyprotein Connecting neurodevelopment to neurodegeneration: a spotlight on the role of kinesin superfamily protein 2A (KIF2A) https://lnkd.in/gAsAFEds fadel tissir Université catholique de Louvain Hamad Bin Khalifa University Microtubules play a central role in cytoskeletal changes during neuronal development and maintenance. Microtubule dynamics is essential to polarity and shape transitions underlying neural cell division, differentiation, motility, and maturation. Kinesin superfamily protein 2A is a member of human kinesin 13 gene family of proteins that depolymerize and destabilize microtubules. In dividing cells, kinesin superfamily protein 2A is involved in mitotic progression, spindle assembly, and chromosome segregation. In postmitotic neurons, it is required for axon/dendrite specification and extension, neuronal migration, connectivity, and survival. Humans with kinesin superfamily protein 2A mutations suffer from a variety of malformations of cortical development, epilepsy, autism spectrum disorder, and neurodegeneration. In this review, we discuss how kinesin superfamily protein 2A regulates neuronal development and function, and how its deregulation causes neurodevelopmental and neurological disorders.

male: female: brain: white matter: different: AI: finds:

#Gender differences are real and objective. #Neuroscientists unveil hidden #brain features daily, busting myths and folklore by addressing human beings as they are, not as they want to be. While this statement might be almost offensive to some individuals, I acknowledge that our #feelings are important, but we can't just override our #nature without consequences. Men and women are more similar than different on both #biological and #neurological levels. Therefore, it would make much more sense to start nurturing the idea that nature has been developing for ages. We are different, and that's actually great, not just good. It makes us special and unique; it makes us unique in the forest of other human beings. Please make sure to find that uniqueness; don't try to be an imagination. While feelings are important, we should never forget that our brains can play tricks on us. Brains are smart; remember that. #genderdifferences #gendersimilarities #neuro #BPSmodel

AI Uncovers Hidden Differences in Male and Female Brain Structures A new AI study focusing on white matter reveals hidden differences in male and female brain structures. The findings could enhance diagnostic tools and treatments for brain disorders.