BioLogic’s Post

💡Very happy to share our recent article, published in Angewandte Chemie. This work was carried out at University of Strasbourg during my PhD in Prof. Marine Desage-El Murr's lab , which was finished by Oscar Charpentier. #OMECA_Lab We showed how the introduction of a remote metal-binding redox site on alloxazine and flavin activates their aromatic ring towards direct C–H functionalization. The utility of the method is demonstrated with the site-selective C6 functionalization of alloxazine and flavin with a CF3 group, Br or Cl, that can be further elaborated into OH and aryl for chemical diversification. It would be a great tool for making alloxazine and flavin photocatalyst. #OMECA_Lab #Unistra #AngewChem #ANR 👇

Check out our new manuscript in Inorganic Chemistry Frontiers on tuning the ligand field, g-factors, hyperfine interactions and magnetisation dynamics of lanthanide coordination complexes by peripheral chemical modifications. https://lnkd.in/d_aF83R4

Check out our recent publication on the "beneficial" degradation of photocatalyst and its impact on the halogen-atom-transfer reaction, published in Angewandte Chemie as an accepted article!

I'm excited to share my latest publication, "Structure and Non-reactive Dynamics of the Dimeric Catalytic Domain of Human Carbonic Anhydrase IX," in Elsevier's Chemical Physics Impact as a part of a special issue "Recent Trends of Physical Chemistry in India". This research uses 1 microsecond molecular dynamics (MD) simulation to compare each of the dimeric and monomeric forms of HCAIX-c in water. While the overall structures are similar, key differences were found: 1. Active Site Reorganization: The dimer shows significant changes in the lifetime of hydrogen bonded water path which is crucial for the rate-determining proton transfer step. 2. Free energy and kinetics of a distal histidine residue: Using Markov State Model (MSM), we observed differences in the stability and kinetics of key Histidine residue sidechain rotamers. Check out the full paper for more details!

Excited to share my recent publication in the International Journal of Biological Macromolecules (IF 8.2) titled "Green and Single-Step Simultaneous Composite Starch Aerogel Formation-High Bioavailability Curcumin Particle Formation." In this study, we explored impregnation of curcumin into the aerogels through supercritical carbon dioxide technology. The aim of study was to develop the bio-based delivery systems based of composite strach/chitosan aerogels to enhanced bioaccessibility of curcumin. https://lnkd.in/gxQhTDiV

Check out our paper on the molecular mechanism of the alternative oxidase (AOX), an enzyme that runs the respiratory chain of many parasites - now out in Chemical Science: https://lnkd.in/dw9FjZHm

Very happy to see Stephen et al.'s work now published in #JACS! As an insider, I can only stress the tremendous effort this took them. The use of Zn(OTf)2 to access the active catalyst species is my favorite finding of this paper, and organic chemists should keep this in mind when trying to develop new methodologies in the future.

As a researcher in fluid flow in porous media, I am pleased to announce that our work, titled “Anomalies of Solute Transport in Flow of Shear-Thinning Fluids in Heterogeneous Porous Media,” has been published in the 𝗣𝗵𝘆𝘀𝗶𝗰𝘀 𝗼𝗳 𝗙𝗹𝘂𝗶𝗱𝘀 𝗝𝗼𝘂𝗿𝗻𝗮𝗹 and has been recognized as an 𝗘𝗱𝗶𝘁𝗼𝗿’𝘀 𝗣𝗶𝗰𝗸. Considering the importance of correctly understanding the transport behaviour of non-Newtonian fluid flow compared to solute transport in the flow of Newtonian fluids, in this study, we developed a computational approach to evaluate and upscale the dispersion of a solute in a shear-thinning (ST) fluid in a heterogeneous porous medium. Our results indicate that the dispersivity is a non-monotonic function of the Peclet number and the shear rate, and this behaviour is pronounced by the heterogeneity of the pore space and spatial correlations between the local permeabilities. As a result, solute transport in ST fluids deviates significantly from the same phenomenon in Newtonian fluids. For further details please check the following link: https://lnkd.in/gkQ2Nkek Special thanks to my supervisor, 𝗣𝗿𝗼𝗳. Vahid Niasar, as well as 𝗣𝗿𝗼𝗳. Muhammad Sahimi and 𝗗𝗿 𝗖𝗵𝗿𝗶𝘀𝘁𝗼𝗽𝗵𝗲𝗿 𝗚𝗿𝗲𝗲𝗻 for their significant contributions. It is a privilege to work with the best in my research area.

Check out our new paper led by Caroline Freissinet on the Nitrogen chemistry for Titan research with the Dragonfly Mass Spectrometer, with a focus on amides and amines!

John Ernest Walker (b. 1/7/1941) British chemist who won a share of the Nobel Prize for Chemistry in 1997 for his pioneering work on how the enzyme ATP synthase catalyses the formation of the "high-energy" compound adenosine triphosphate (ATP). These molecules of ATP function as a carrier of energy in all living organisms, whether simple bacteria, fungus or plant life, or higher animals and humans. ATP takes in the chemical energy released when nutrients are metabolized, and carries that energy to the various reactions that require energy. Such reactions include cell-building, the contraction of muscle fibers, or nerve signals. https://lnkd.in/eXnWJTu