Biomedicines MDPI’s Post

Calcium crosstalk is key in esophageal integrity: Tulane researchers discover that the ability of epithelial cells lining the throat to sense calcium may be critical in esophageal health. Disrupting this ability led to gene expression shifts and #microbiome changes. This research may pave the way for better treatments of esophageal diseases. #TulaneResearch #GERD Read more here: https://ow.ly/O6N550QEOcW Image: Tissue from esophagus in subjects with normal (control) versus impaired calcium-sensing (CaSR -/-) epithelial cells at baseline or subjected to infection by aspergillus. Impaired calcium sensing resulted in more cells expressing markers for inflammation (brown).

Gene therapy faces challenges such as delivery methods, immune response, and off-target effects. However, it holds promise for treating genetic disorders and diseases. Advancements in technology and research may overcome these challenges. 🧬 #GeneTherapy #MedicalInnovation #FutureTreatment.

#CBCAwardee Dr Sara Lutz of University of Illinois Chicago's College of Medicine recently published results connecting the Wnt/Beta-catenin pathway, which affects blood-brain barrier integrity to #brainFog after #Covid infection. Dr. Lutz’s team looked at the blood vessels found in the #brains of elderly rats who suffered a mild case of Covid. Within these rats, they found that a gene pathway associated with maintaining the blood-brain barrier was less active. Dr. Lutz used gene therapy to stimulate that pathway, the Wnt/Beta-catenin pathway, and discovered it could prevent #brainDamage caused by the Covid virus, in rats. Obviously, this is a long way off from use in human beings, but, ‘“Anytime you can identify a molecular mechanism that contributes to a disease, you’re learning about basic biology and what causes disease in general,” Dr. Lutz said. “This research suggests that improving blood-brain barrier integrity could have benefits in preventing complications of COVID-19.”’ Read more here: https://lnkd.in/gSKiVkMT

🔬🧬 Exciting News Alert! 📢 Our latest research article titled "A Meta-Analysis Approach to Gene Regulatory Network Inference Identifies Key Regulators of Cardiovascular Diseases" has just been published! 🔍 Using a meta-analysis approach, we've delved deep into the complex interplay of genes involved in cardiovascular health, pinpointing key regulators that could hold the key to understanding and potentially treating these diseases. Let's continue to push the boundaries of scientific discovery and make strides towards a healthier future together! 💪 #CardiovascularResearch #GeneRegulation #Science #Research #Healthcare #MetaAnalysis https://lnkd.in/dzwjSPpG

Is mRNA technology gene therapy? Regulations are very different! Join on Substack: https://lnkd.in/ejXM5s68 #COVID19 #CovidVaccines Watch videos at McMillan Research: https://lnkd.in/g3vJ8uXx #covid #medicine #research

Rare Disease Tech: Researchers call for individualized gene therapies to be more widely accessible https://lnkd.in/e7xebXAM Regulatory innovation is key in rare disease research. We can help. #raredisease #clinicalresearch

Researchers reveal that individuals with two copies of the APOE4 gene variant are almost guaranteed to develop Alzheimer's and experience symptoms earlier. The study, published in Nature Medicine, may redefine this group as having a distinct genetic form of the disease, potentially impacting research, diagnosis, and treatment approaches. The findings highlight the importance of genetic factors in Alzheimer's development and progression. #AlzheimersResearch #GeneticRisk #APOE4Variant #CheckItNow

'Marks further noted that “certain rare diseases may only have a population of 50 patients in the US and the EMA has 75 patients and Japan has a number of patients. The 50 patients in the US do not tip the net balance calculations into the positive. If you aggregate everyone, you have a much higher chance of tipping that calculation to where it actually makes sense” to incentivize sponsors to invest in these treatments.' I think it is a great approach to allow to use combined data from different regions in gene therapy development. Let's see what they will issue as guideline. https://lnkd.in/eB8s9ghR

Deciphering the Complex Etiology of Type 1 Diabetes. Type 1 #diabetes (T1D) is a complex #autoimmune disease with a multifactorial etiology. #Genetic predisposition, environmental triggers, and immune dysregulation contribute to the development of this chronic condition. #Diagnoses involves a combination of #clinical evaluation, laboratory tests, and #medical history assessment. T1D impacts millions globally, with its incidence rising notably among African American and Hispanic youth populations. A variety of #treatment options, including maintenance therapy, #transplants, gene therapy, #vaccines, #antibodies, and combination therapies, are being explored to improve outcomes and quality of life for individuals with #T1D. View insights: https://lnkd.in/diCUb4dr

Deciphering the Complex Etiology of Type 1 Diabetes. Type 1 #diabetes (T1D) is a complex #autoimmune disease with a multifactorial etiology. #Genetic predisposition, environmental triggers, and immune dysregulation contribute to the development of this chronic condition. #Diagnoses involves a combination of #clinical evaluation, laboratory tests, and #medical history assessment. T1D impacts millions globally, with its incidence rising notably among African American and Hispanic youth populations. A variety of #treatment options, including maintenance therapy, #transplants, gene therapy, #vaccines, #antibodies, and combination therapies, are being explored to improve outcomes and quality of life for individuals with #T1D. View insights: https://lnkd.in/diCUb4dr