Biomedicines MDPI

#HighlyCitedPapers   📝 Characterization of the Ang/Tie2 Signaling Pathway in the Diaphragm Muscle of DMD Mice — Lin, McClennan and Hoffman.   In this paper, the authors aimed to characterize the Ang/Tie2 signaling pathway within the diaphragm muscle of mouse models of Duchenne #muscular #dystrophy.   Full text is available 👇 https://lnkd.in/dUd46v2q   #medicine #health #research #science

#HighlyCitedPapers   📝 𝐒𝐭𝐚𝐠𝐞-𝐃𝐞𝐩𝐞𝐧𝐝𝐞𝐧𝐭 𝐋𝐞𝐯𝐞𝐥𝐬 𝐨𝐟 𝐁𝐫𝐚𝐢𝐧-𝐃𝐞𝐫𝐢𝐯𝐞𝐝 𝐍𝐞𝐮𝐫𝐨𝐭𝐫𝐨𝐩𝐡𝐢𝐜 𝐅𝐚𝐜𝐭𝐨𝐫 𝐚𝐧𝐝 𝐌𝐚𝐭𝐫𝐢𝐱 𝐌𝐞𝐭𝐚𝐥𝐥𝐨𝐩𝐫𝐨𝐭𝐞𝐢𝐧𝐚𝐬𝐞 𝟗 𝐢𝐧 𝐭𝐡𝐞 𝐏𝐫𝐨𝐠𝐧𝐨𝐬𝐢𝐬 𝐨𝐟 𝐂𝐨𝐥𝐨𝐫𝐞𝐜𝐭𝐚𝐥 𝐂𝐚𝐧𝐜𝐞𝐫 — Večurkovská, et al.   In this paper, the authors tested the hypothesis that BDNF can regulate MMP-9 production in the early stages and progression of #colorectal #cancer.   Full text is available 👇 https://lnkd.in/dfFJ3_Hk   #medicine #health #research #science

📝 Effect of Probiotic Therapy on Neuropsychiatric Manifestations in Children with Multiple Neurotransmitter Disorders: A Study — Matiș, et al.   The purpose of this study is to examine the psychoemotional effects and cognitive functioning in children with gastrointestinal disorders who undergo #psychobiotherapy.   Full text is available 👇 https://lnkd.in/dN9eVRJi   #medicine #health #research #science

#HighlyCitedPapers   📝 𝐀𝐒𝐓-𝟎𝟎𝟏 𝐈𝐦𝐩𝐫𝐨𝐯𝐞𝐬 𝐒𝐨𝐜𝐢𝐚𝐥 𝐃𝐞𝐟𝐢𝐜𝐢𝐭𝐬 𝐚𝐧𝐝 𝐑𝐞𝐬𝐭𝐨𝐫𝐞𝐬 𝐃𝐨𝐩𝐚𝐦𝐢𝐧𝐞 𝐍𝐞𝐮𝐫𝐨𝐧 𝐀𝐜𝐭𝐢𝐯𝐢𝐭𝐲 𝐢𝐧 𝐚 𝐌𝐨𝐮𝐬𝐞 𝐌𝐨𝐝𝐞𝐥 𝐨𝐟 𝐀𝐮𝐭𝐢𝐬𝐦 — Um, et al.   In this paper, the authors conducted experiments to demonstrate the efficacy of AST-001 as L-Serine that alters the regulation of the firing rate in #dopamine #neurons by inhibiting small conductance Ca2+-activated K+ channels (SK channels).   Full text is available 👇 https://lnkd.in/dzdqP4PX   #medicine #health #research #science

One of the problems with using MSCs (mesenchymal stem cells) to treat different neurodegenerative diseases of the central nervous system is their low ability to spontaneously differentiate into functional neurons. In this paper, the authors aimed to investigate how the co-overexpression of the BCL and BDNF genes affects the ability of genetically modified MSCs to differentiate into GABA-ergic #neurons. 🔬 Effects of the Co-Overexpression of the BCL and BDNF Genes on the Gamma-Aminobutyric Acid-Ergic Differentiation of Wharton’s-Jelly-Derived Mesenchymal Stem Cells — Borkowska, Morys, Zielinska and Kowalski.   Full text is available 👇 https://lnkd.in/dRSmxg-a   #medicine #health #research #science

In this review, the authors delineate the SIN3a-associated epigenetic mechanisms in cancer and PAH cells and highlight their impact on cell survival and proliferation. Furthermore, they explore in detail the role of SIN3a in cancer to provide new insights into its emerging role in PAH pathogenesis. 📝 𝐒𝐰𝐢𝐭𝐜𝐡-𝐈𝐧𝐝𝐞𝐩𝐞𝐧𝐝𝐞𝐧𝐭 𝟑𝐀: 𝐀𝐧 𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐑𝐞𝐠𝐮𝐥𝐚𝐭𝐨𝐫 𝐢𝐧 𝐂𝐚𝐧𝐜𝐞𝐫 𝐰𝐢𝐭𝐡 𝐍𝐞𝐰 𝐈𝐦𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 𝐟𝐨𝐫 𝐏𝐮𝐥𝐦𝐨𝐧𝐚𝐫𝐲 𝐀𝐫𝐭𝐞𝐫𝐢𝐚𝐥 𝐇𝐲𝐩𝐞𝐫𝐭𝐞𝐧𝐬𝐢𝐨𝐧 — Jankowski, et al. Full text is available 👇 https://shorturl.at/HCSiC

#ParticularInterestPaper   🔬 Breaking the Fear Barrier: Aberrant Activity of Fear Networks as a Prognostic Biomarker in Patients with Panic Disorder Normalized by Pharmacotherapy — Yan, et al.   This longitudinal resting-state functional magnetic resonance imaging study aimed to investigate the spontaneous #neural activity in patients with #panic disorder and its changes after pharmacotherapy, with a focus on determining whether it could predict treatment response.   Full text is available 👇 https://lnkd.in/dYQp2-C8   #medicine #health #research #science

In the following paper, the authors summarize the current knowledge about specific ion channels and transporters located in the mammalian #sperm plasma membrane, which are intricately involved in the initiation of changes within the ionic milieu of the sperm cell, leading to variations in the sperm membrane potential, membrane depolarization and hyperpolarization, changes in sperm motility and capacitation to further lead to the acrosome reaction and sperm–egg fusion.    🔬 𝐓𝐚𝐫𝐠𝐞𝐭𝐢𝐧𝐠 𝐀𝐝𝐢𝐩𝐨𝐧𝐞𝐜𝐭𝐢𝐧 𝐢𝐧 𝐁𝐫𝐞𝐚𝐬𝐭 𝐂𝐚𝐧𝐜𝐞𝐫 — Benko, et al.    Full text is available 👇 https://lnkd.in/dkcNE4_V   #medicine #health #research #science

#HighlyCitedPapers   📝 Epileptic Patient Activity Recognition System Using Extreme Learning Machine Method — Ayman, et al.   In this research, the authors proposed a Deep Learning model that enables the detection of epileptic seizures in an automated way, addressing a need in clinical research.    Full text is available 👇 https://lnkd.in/dXZBa7-a   #medicine #health #research #science

The aim of the following paper was to overview the body-composition-related changes and molecular effects of different #chemotherapy agents used in #cancer treatment on skeletal-muscle remodeling.   📝 𝐂𝐡𝐞𝐦𝐨𝐭𝐡𝐞𝐫𝐚𝐩𝐲-𝐈𝐧𝐝𝐮𝐜𝐞𝐝 𝐌𝐨𝐥𝐞𝐜𝐮𝐥𝐚𝐫 𝐂𝐡𝐚𝐧𝐠𝐞𝐬 𝐢𝐧 𝐒𝐤𝐞𝐥𝐞𝐭𝐚𝐥 𝐌𝐮𝐬𝐜𝐥𝐞 — Pedrosa, et al.    Full text is available 👇 https://lnkd.in/d27X4bAg   #medicine #health #research #science