Bioneex’s Post

I'm thrilled to share that my review article, "Exploring the Potentials of Hyaluronic Acid-coated Polymeric Nanoparticles in Enhanced Cancer Treatment by Precision Drug Delivery, Tackling Drug Resistance, and Reshaping the Tumour Micro Environment" has been published in Current Medicinal Chemistry (IF: 4.184) This review dives into the cutting-edge potential of hyaluronic acid-coated nanoparticles for improved cancer therapy. I'm excited about the contributions this research can make to the field of precision medicine and targeted drug delivery. Special thanks to my mentor Dr. Sankha Bhattacharya sir for his valuable support 📈 Interested in nanomedicine and innovative cancer treatments? Check out my full article: 👉https://lnkd.in/dYWnWSwJ #cancerresearch #nanomedicine #drugdelivery #cancer #hyaluronicacid #nanoparticles #oncology #innovation #medicalresearch #science #precisionmedicine #healthcare #biotechnology #pharmaceuticals #medicine #research #biotech #reviewarticle #published #currentmedicinalchemistry

Physiomics plc’ Virtual Tumour™ QSP model allows simulations of different drug administrations to be quickly made and the best schedule regimen chosen for further testing in vivo. 💡💊 Our model offers a versatile and cutting-edge approach for predicting and optimising schedules and combinations for a wide range of molecules, including small molecules and biotherapy. By prioritising the most effective drug combinations, our model helps you avoid costly trial-and-error approaches when determining the best administration schedules. Curious about how we can assist you in de-risking and accelerating your drug development pipeline? Find out more: https://lnkd.in/e5WVtecd #Cancer #DrugDevelopment #Insilico #VirtualTumour #TranslationalModelling #CancerDrugs #CancerSimulation #CombinationTherapies #BioTech #Pharma #PYC

Innovative Combination of Chemical Drug and Near-infrared Light Successfully Targeted Cancerous Cells: A novel combination drug designed to combat cancer by manipulating calcium ions inducing a lethal "calcium storm" within tumor cells. The scientists strategically targeted two distinct calcium channels within the cell: one residing in the outer membrane and the other located in the endoplasmic reticulum—an organelle responsible for storing calcium ions. To generate the necessary ROS for opening the outer membrane calcium channel, the research team employed a dye known as indocyanine green. This bioactive agent can be activated through exposure to near-infrared light, a process that not only stimulates the production of ROS but also raises the local temperature. #cancer #oncology #prostatecancer #skincanc #drugdiscovery #drugdelivery #formulation #drugdevelopment #pharmaceuticals #medicalsciences #pharmaceutics #medicine #research Ghaleb Husseini

#siRNAs, a subclass of #oligonucleotides, can selectively silence disease-causing genes, offering new therapeutic opportunities. #GalNAc-siRNA conjugates have emerged as a key strategy in cancer therapy due to their targeting capabilities. Read this WuXi TIDES case study to see how our integrated CMC services managed oligonucleotide synthesis, GalNAc supply, formulation development, manufacturing, and analytical support. Using innovative conjugation chemistry and tailored analytical studies, we significantly improved crude purity and yield, delivering two siRNA-GalNAc CMC packages ready for IND submission within 14 months. Visit our website: https://lnkd.in/g6AmChYd #WuXiTIDES #siRNAs #oligonucleotides #therapies

We are delighted to continue our new content series: 'Molecule Builder'! Here we highlight selected sets of Building Blocks from https://buff.ly/43RYaVR, which serve as excellent starting materials for the analog synthesis of recently approved drug molecules. Fruquintinib (FRUZAQLA®) is a novel, highly selective, and potent oral anticancer drug approved by the FDA for treating metastatic colorectal cancer (mCRC), significantly improving overall survival (OS) in heavily pretreated patients. It functions as a tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR)-1, -2, and -3. VEGFRs are crucial regulators of tumor angiogenesis, the process of new blood vessel formation essential for tumor growth and metastasis. The final step in Fruquintinib synthesis involves a reaction of substituted quinazoline with a benzofuran derivative. Two selected sets of Building Blocks, containing both parts – quinazolines (555 compounds) (https://buff.ly/3sBum3d) and bicyclic fused furans (1018 compounds) (https://buff.ly/47c6qCC ), could be a perfect starting point for your research! #chemspace #openscience #research #science #drugdiscovery #chemicals #medicinalchemistry #drugdevelopment #chemistry #researchanddevelopment #search #chemicalindustry #science #structures

🌟𝗡𝗲𝘄 𝗕𝗶𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰 𝗔𝗻𝘁𝗶𝗯𝗼𝗱𝘆 𝗶𝗻 𝗦𝘁𝗼𝗰𝗸: 𝗧𝗲𝗰𝗹𝗶𝘀𝘁𝗮𝗺𝗮𝗯🚀🧬 Teclistamab from the original drug Tecvayli®, a new #bispecific antibody, is making strides in the fight against multiple myeloma. 💪 Utilizing advanced biotechnology, Teclistamab simultaneously targets T cells and cancer cells, recruiting T cells to destroy the malignant cells. This innovative approach offers new hope for patients battling this incurable blood cancer. 🎗️ Visit our online shop to access Teclistamab and other licensed molecules in smaller units. 🛒 We also offer historical batches of original and biosimilar drugs for your research and early drug development projects. 🔬 #antibody #bloodcancer #biotechnology #cancerresearch #immunotherapy #globalreach #research #drugdevelopment #accessibleresearch

#ACROHighlights [Featured Product] 🔑 Unleash the Potential of MMPs in Cancer Therapeutics 🔬 Unlock the secrets of the tumor microenvironment with our recombinant MMP proteins. Matrix Metalloproteinases (MMPs) are key players in remodeling the TME, driving tumor growth, invasion, and metastasis. Explore our premium MMP products (MMP-1, MMP-2, MMP-3, and more) to uncover new cancer research and therapeutic development frontiers. Leverage the versatile capabilities of these enzymes to propel your pharmaceutical R&D to new heights. 💊💪 🔗https://lnkd.in/gm7TPZbd #TumorMicroenvironment #MatrixMetalloproteinases #CancerResearch #Biotechnology #MMPs

The article "Antibody drug conjugate: the 'biological missile' for targeted cancer therapy" by Fu et al. explores the role of ADCs in targeted cancer treatment. It discusses ADC structure/mechanism, advantages over chemotherapy, and insights into development/applications. In summary, this article highlights the promise of ADCs as "biological missiles" against cancer. KSB contributes significantly through end-to-end ADC research, analytical testing, process optimization, GMP production and regulatory compliance. By leveraging our specialized expertise, we can enable manufacturing of high-quality ADCs to advance patient outcomes. Contact us to learn more! Article link: https://lnkd.in/gNN7epbY #AntibodyDrugConjugate #TargetedTherapy #CancerTreatment #CDMO