Broad Institute of MIT and Harvard’s Post

I just shared the upcoming webinar featuring Klaus Lindpaintner, MD, MPH on 👉Glycomics and glycoproteomics: A (not so) new frontier in biology 👉Dec 13, 10 am EST 👉Register: https://lnkd.in/eBqx2F2N I also would like to recommend this article where he explains the field of glycoproteomics, highlighting its potential to revolutionize biomarker discovery and clinical research. He emphasizes the significance of glycosylation, the most common post-translational modification of proteins, and its profound impact on protein structure, function, and disease development. https://lnkd.in/evR2fBZp #glycoproteomics #biomarkers #translationalresearch #personalizedmedicine #futureofmedicine

LHI Lecture March 13, noon: “Insights from Atrial Fibrillation Genomics: From Bedside to Bench and Back Again” Mina Chung, M.D. Professor of Medicine Cleveland Clinic Lerner College of Medicine Case Western Reserve University More about Dr. Chung from the Cleveland Clinic website: https://lnkd.in/gArH2ffS Location: 1-101 Microbiology Research Facility (MRF) 689 23rd Ave SE, Minneapolis, MN Map: https://lnkd.in/gu3dWwms Webcast @ z.umn.edu/lhi-webcast **Note: This lecture will not be recorded. Learning Objectives Review our understanding of AF pathophysiology and limitations to current therapeutic options. Recognize that there are genetic associations with common atrial fibrillation. Assess the potential of genomic research to developing potential new upstream approaches to AF prevention

📚✨ Unlock the power of seamless literature preparation with Bio | Reflect! For a limited time, enjoy 15% off your first fast-track literature preparation for regulatory approval or exploratory reading. 🚀 Fast-track your project life cycle from initial exploration to patents, clinical trials, and regulatory approval. Bio | Reflect helps you select the most relevant scientific literature, linking it directly to your data for comprehensive scientific exploration. 🔬 With Bio | Reflect, you benefit from: - Seamlessly integrated disease, gene, and chemical annotations - Uncovering gene-disease associations and more from publications - An unbiased, at-a-glance, and up-to-date global overview of publications with topic-based clustering 🌐 Dreaming of breezing through your literature searches with ease? Get in touch 👉 https://lnkd.in/eac5VRS4 #ScientificResearch #LiteratureReview #RegulatoryApproval #BioReflect

Excited to share our latest in the nefzger lab at UQ Institute for Molecular Bioscience in Cell_Metabolism. We uncover a common transcription factor pattern linked to organismal maturation and ageing. Link to the paper: https://lnkd.in/esEQewu9 #multiomics #aging #epigenome #transcription #regulation #development

So, aging is not a linear process, science confirms. According to research from Stanford University (link in the comments), the molecular processes involved in aging seem to occur in two distinct phases, with significant shifts happening around age 44 and again around age 60. The study involved analyzing a variety of molecular and microbial data from individuals aged 25 to 75, using techniques such as transcriptomics, proteomics, metabolomics, and 16S rRNA gene sequencing. Key findings include: ✔ Significant molecular and microbial shifts occur around age 44, affecting both men and women. ✔Another set of changes happens around age 60, impacting skin, muscle, kidney function, and immune response. ✔ The study provides new insights into aging, suggesting that aging processes may not be linear but occur in distinct phases. I've been delving a bit deeper into the science of aging lately, and I think there is no better place to learn about it than the 11th Aging Research and Drug Discovery Meeting (#ARDD2024) to be held on Aug 26-30 in Copenhagen. So, I am traveling there and will be happy to meet/chat if you are there. Also, happy to reiterate that BioPharmaTrend.com is an official media partner to the event, so feel free to subscribe to Where Tech Meets Bio (Substack Newsletter) newsletter to receive exclusive insights from the event, as well as on-site reporting. Share this with someone who might benefit from the event, which also has virtual attendance option! #aging #longevity #biotech #biopharmatrend Aging Research & Drug Discovery Meeting Alex Zhavoronkov David A. Sinclair A.O., Ph.D. Garri Zmudze Morten Scheibye-Knudsen Evelyne Bischof, MD, PhD

Mun et al. demonstrate unbiased measurements of proteomes and post-translational modifications at the single-cell level in recent study. Learn more: https://bit.ly/3yVv4vy Using diaPASEF, researchers identified an average of 2,548 proteins per single cell across normal cholangiocytes and cholangiocarcinoma cell lines. The study revealed signaling heterogeneity, detected mutant proteins like KRAS G12D, and identified various PTMs in individual cells. The approach was extended to single nuclei, capturing subcellular proteome dynamics and measuring drug-induced epigenetic changes. This work showcases the power of single-cell proteomics to complement genomics data and provide a more comprehensive understanding of cellular states and drug responses. The IonOpticks Aurora Elite CSI helped the researchers achieve high-quality peptide separation, enabling the deep proteome coverage in this study. Learn more: https://bit.ly/3yVv4vy

Epigenetics & Chromatin! Check out our latest publication, “CREdb: A Comprehensive Database of Cis Regulatory Elements and their Activity in Human Cells and Tissues.” This groundbreaking work is a collaborative effort between the incredible teams at Takeda and Rancho BioSciences. Key Highlights: - CREdb is a meticulously curated database designed to provide extensive data on cis regulatory elements. - It offers invaluable insights into their activity across various human cells and tissues. - This resource aims to accelerate research in genetics, molecular biology, and related fields. We believe CREdb will be a crucial asset for researchers, offering a robust foundation for further advancements in understanding gene regulation and its implications in health and disease. Huge congratulations and thanks to all the brilliant minds involved in this project. Your dedication and hard work have made this invaluable tool possible. For those interested in exploring CREdb and diving into the depths of epigenetic landscapes, check out the publication https://hubs.ly/Q02LZjN60 . #Epigenetics #Chromatin #Genomics #Bioinformatics #Takeda #RanchoBioSciences #REdb #GeneRegulation #BiomedicalResearch

Excited to be at #GCSB2024, the German Conference on Synthetic Biology, with our fantastic project partners from Leipzig University! 🎉 Our rockstar PhD students, Jule Walter and Leonhard Sidl are showcasing our latest research with a poster titled "Design of synthetic riboswitches that modulate mRNA stability." 🧬🔬 In this study we engineer functional RNAs together with RNA aptamers to form ligand-inducible molecular devices that modulate the expression and degradation of #mRNA. Our findings not only advance the field of #SyntheticBiology but also hold potential implications for future #healthcare applications, particularly in developing more precise gene regulation technologies. Find the full poster here: https://lnkd.in/d9DDfsdJ #RNA #RNAStability #HealthcareResearch #Biotechnology #GeneticEngineering #FutureOfHealthcare #ComputationalBiology #Biochemistry #ViennaRNA

Check out our recent paper with Takeda on creation on CREdb, a new resource to allow exploration of epigenome in disease. #genetics #epigenetics #drugdiscovery

Our preprint on metabolic protein variability is now on bioRxiv! Almost 40% of the human enzymes are differentially expressed (on the protein level) in the neighboring cells. We see this both in cell lines with the same genetic background, cultured under the same conditions, and in tissues, such as liver or pancreas. Read more at: https://lnkd.in/dTjQej_E It was a great pleasure working on it together with Christian Gnann, Anthony Cesnik, Trang Le, Sanem Sariyar, Diana Mahdessian, PhD, Rutger Schutten, Preethi Raghavan, Manuel Leonetti, Cecilia Lindskog, Mathias Uhlen, Ulrika Axelsson, Emma Lundberg #metabolism #cellmetabolism #spatialproteomics