CDI Labs’ Post

mRNA-based therapeutics: looking beyond COVID-19 vaccines ▶️mRNA-based therapeutics offer rapid, potent, and transient protein expression ▶️mRNA technology spans vaccines, immunotherapeutics, protein replacement therapy, and genomic editing ▶️ It is suitable for treating infectious diseases, cancer, and monogenic disorders ▶️ Challenges remain in stability, expression duration, delivery efficiency, and targetability ▶️ Optimization efforts are underway through preclinical and clinical studies ▶️ Targeted delivery to specific cells and organs is being developed for tailored therapeutics. Read more on: https://lnkd.in/dNhAXaqh #mRNAtechnology #mRNA #mrnavaccines #mrnatherapeutics The Lancet

We're counting down to IO360! Don't miss the panel presentation, State of the IO Market, Investments, and Deals: Investment Trends in IO, featuring Lumanity's Jeff Bockman. For more information, visit and use code "LUM20" for a 20% discount on your registration, and be sure to schedule time to connect with us on-site at contact@lumanity.com. #IO360nyc #Immunology #Oncology #Pharma #Biotech #ImmunoOncology #IO360

Hello connections! I am delighted to share that I have participated in the 40th Webinar,conducted by Society of Pharmaceutical Sciences and Research on the topic 'Adopting genome editing technology in combating cancer disease'. 🧬I have learnt the following points : ●Principle of Carcinogenesis ●Characteristics of cancerous cell ●Risk factors and burden of Cancer disease ◇Adoptive cell therapy ◇Activation of Immune checkpoints ◇Concept of CRISPR-edited T cells binding to cancer cells and eventually killing them. ◇Benefits of adopting GENOME EDITING TECHNOLOGY in combating cancer disease. #webinar #SPSR #pharmacy

Unlocking Insights into Immune Cell Signaling with Celentyx's #Phosphoflow Assays Celentyx’s cutting-edge phosphoflow assays are pivotal in identifying and characterising biologic and small-molecule modulators of immune cell signaling. From screening to potency to benchmarking assays, these powerful techniques quantify phosphorylated signaling molecules to define drug action upon individual immune cell subsets, whether in vitro or during clinical trial evaluation. The exemplar below demonstrates induction of phosphorylated STAT3 in response to the pro-inflammatory cytokine IL-6 that was quantified in ten immune cell subsets (subsets of human CD4 T cells shown as the example) along with the impact of two clinically utilised JAK inhibitors, ruxolitinib and baricitinib, evaluated with cells from multiple donors allowing robust pharmacological analysis. Elevate your research and gain a deep understanding of immune cell dynamics with Celentyx's phosphoflow assays, your gateway to better understanding the action and unlocking the potential of novel therapeutics.  #ImmuneCellSignaling #PhosphoflowAssays  https://lnkd.in/gCgk8tJ6

We’re looking forward to attending BTIG’s Virtual Biotechnology Conference 2024 this week and connecting with others in the field on our clinical progress and personalized approach to treating solid tumors.    #btigbiotechnologyconference #btig #btigconferenceandevents #btigcorporateaccess #btigresearch #btiginvestmentbanking #biotechnology #immunology #immunooncology

Explore the transformative potential of therapeutic antibodies in healthcare. 🌟 These immunotherapies, mimicking vital immune components, precisely target diseases. They identify and neutralize harmful substances by binding to specific antigens, blocking their effects. In cancer treatment, they impede tumor growth by disrupting cellular connections and delivering drugs directly to cancer cells. 🧬 Share your insights on the role of therapeutic antibodies in revolutionizing disease treatment. 😎 #HealthcareInnovation #antibodies #diseaseawareness #preclinical #preclinicalresearch #biologie #biotech #biotechinnovation #biotechnologie #biotechnology

Biomarkers of 🔥Inflammation and 🦠Immune Response Perhaps you've heard of juggling while running? Prepare for multiplexing and accelerating! Choosing the right biomarker assay is crucial if you want to accelerate your clinical or preclinical research. To increase both speed and sensitivity, you can employ a panel of validated protein biomarkers. Olink Target 48 for human or mouse samples is a multiplexed proteomics assay, providing quantitative data for 44 to 89 biomarkers in a single workflow, and from minute sample volumes. We deliver comprehensive statistical evaluations along with publication-ready figures, so you can move forward faster. Download our price list and current campaign details at https://lnkd.in/eAak8B4, or contact us at campaign@bioxpedia.com. #ClinicalResearch #Preclinical #Immunology #Inflammation #Biomarkers Image: Guinness World Record-holder Owen Morse joggling [sic] during a training session at University of California, Irvine, in 1988

I am really impressed by the systematic approach the authors took in investigating the data we all have been extracting over the years. By integrating CPTAC proteogenomics data from 1,043 patients across 10 cancer types with additional public datasets, they identified potential therapeutic targets. This comprehensive analysis offers valuable insights for drug repurposing and therapy development. Truly great work! Explore the findings here: https://lnkd.in/dbgX2w_Q https://lnkd.in/dbgX2w_Q #CancerResearch #Proteomics #DrugDiscovery #Bioinformatics

Come speak with us at ASCO about how Strata can advance and augment your ADC development plans for both marketed and investigational ADCs!

Genomics breakthroughs are transforming vaccines and treatments, with mRNA's potential beyond COVID-19. Drawing on GlobalData's exclusive data and insights, this report explores mRNA's potential in infectious disease and oncology, analyzing pipelines and discussing opportunities and challenges with a focus on safe and effective drug delivery packaging. https://bit.ly/3w8uKb6 #DiscoverDatwyler