PRODUCT: #VirScan® PhIP-Seq (Phage ImmunoPrecipitation Sequencing) is a powerful method that combines DNA high-throughput sequencing with next-gen proteomics for multiplexed analysis of an individual’s antibody response to past viral exposures. Designed to target over 68,000+ annotated viral protein sequences from most known vertebrate viruses, including mosquito-borne and tick-borne viral genomes, VirScan aids in understanding past infections, informing vaccination strategies, and uncovering novel biomarkers for disease detection and monitoring. Contact us today to discover the power of VirScan and see how it can transform your understanding of antibody repertories. https://lnkd.in/gkUyppK3 #antibodies, #antibody, #phipseq, #proteomics, #monoclonalantibodies, #biomarkers, #diseaseresearch, #viralinfections, #viralhistory
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ON-DEMAND WEBINAR: NGS Strategies for Vaccine Development and Surveillance of Respiratory Viruses 🔬 Unlock the future of vaccine development and viral surveillance with our on-demand webinar! Our expert speaker dives into the challenges of analyzing low viral load clinical samples and provides strategies to enhance sensitivity and specificity in NGS-based assays. 📊 Key Takeaways: ▪ Leverage whole-genome sequencing (WGS) to detect multiple viral strains within a single sample. ▪ Understand the complex interplay between pathogens and their implications for clinical management and public health. ▪ Gain insights into NGS assay development and validation, including workflow optimization and methodological choices (probe-based vs. amplicon sequencing). ▪ Explore comprehensive NGS tactics for analyzing respiratory RNA viruses and key gene sequences. This webinar is essential for anyone involved in clinical management, surveillance efforts, and outbreak control measures. Don’t miss out on this opportunity to enhance your knowledge and skills! Watch the webinar now: https://lnkd.in/eZCKiRxT #NGS #WholeGenomeSequencing #ClinicalManagement #Eurofins
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"Journal of Virological Methods for Laboratory Diagnosis and Characterization of Monkeypox Virus (MPXV)" Critically examines the range of virological methods for the diagnosis and characterization of Monkeypox Virus (MPXV), with a particular focus on lessons learned from the global 2022 Mpox outbreak. It highlights the significance of molecular techniques such as real-time PCR and digital PCR, which offer rapid and accurate MPXV detection, and the essential role of whole genome sequencing in understanding viral evolution. Traditional methods like electron microscopy and virus isolation remain vital for complete viral characterization, especially in vaccine development. A multidisciplinary approach combining both advanced and traditional methods is recommended for effective outbreak surveillance and control.
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Massive study evaluates the ability of 102 RNA viruses (enveloped) to enter human cells. The study performed by Spanish researchers at the Universidad de Valencia, monitored the ability of pseudoviruses (VSV-based) carrying viral receptor-binding proteins (typically called viral spike) from 14 viral families. Permissivity to infection was evaluated with 48 transformed cell lines originated from 8 different tissues (from the NCI 60 panel). The study also evaluated the role in viral tropism of other host factors beyond viral receptors. 79 of the 102 viruses evaluated had never been reported to infect human cells. Of the 56 mammalian viruses tested, 41 have only found in the wild, and 15 of them infect domesticated animals. In addition to a massive amount of novel information on viral tropism, entry receptors and host factors (some with novel roles in viral tropism), the research comes with an interesting conclusion: viral entry and the early stages of infection are not the major barrier to zoonosis among most RNA viruses. The sole presence of a receptor is not a limiting factor for viral entry in most cases. Many other factors, acting at multiple stages in the life cycle of the virus, likely play a more important role in determining virus tropism. Proteases, products involved in innate immunity, cellular transport, endocytosis, and many other cellular pathways may play more important roles impeding or facilitating at a post-entry stage the replication of animal viruses in human cells. Epidemiological and ecological factors may also play an important role in viral zoonosis. As the authors state: “entry is only the first step that a virus must complete to productively infect a cell” #viruses #pandemic #infectiousdiseases #globalhealth #publichealth #medicine #biotechnology #pharmaceuticals #antivirals #zoonosis
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Senior Scientist Immunology - Project leader - Team Manager - Immunotherapies & Transversal studies in oncology and infection diseases.
Very interesting study on the first step of viral infection …
Massive study evaluates the ability of 102 RNA viruses (enveloped) to enter human cells. The study performed by Spanish researchers at the Universidad de Valencia, monitored the ability of pseudoviruses (VSV-based) carrying viral receptor-binding proteins (typically called viral spike) from 14 viral families. Permissivity to infection was evaluated with 48 transformed cell lines originated from 8 different tissues (from the NCI 60 panel). The study also evaluated the role in viral tropism of other host factors beyond viral receptors. 79 of the 102 viruses evaluated had never been reported to infect human cells. Of the 56 mammalian viruses tested, 41 have only found in the wild, and 15 of them infect domesticated animals. In addition to a massive amount of novel information on viral tropism, entry receptors and host factors (some with novel roles in viral tropism), the research comes with an interesting conclusion: viral entry and the early stages of infection are not the major barrier to zoonosis among most RNA viruses. The sole presence of a receptor is not a limiting factor for viral entry in most cases. Many other factors, acting at multiple stages in the life cycle of the virus, likely play a more important role in determining virus tropism. Proteases, products involved in innate immunity, cellular transport, endocytosis, and many other cellular pathways may play more important roles impeding or facilitating at a post-entry stage the replication of animal viruses in human cells. Epidemiological and ecological factors may also play an important role in viral zoonosis. As the authors state: “entry is only the first step that a virus must complete to productively infect a cell” #viruses #pandemic #infectiousdiseases #globalhealth #publichealth #medicine #biotechnology #pharmaceuticals #antivirals #zoonosis
Viral Entry is a Weak Barrier to Zoonosis - bioRxiv
scoop.it
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Manager- Product Management, Next Generation Sequencing Application Support (PAN India) at DSS Takara Bio India Pvt. Ltd
SMARTer Mouse BCR IgG H/K/L Profiling Kit was used to prepare mouse antibody heavy- and light-chain variable region sequencing libraries , the researchers identified a few key mutations within the BCR locus that revealed expanded B-cell clones as precursors for secreted tier 2 bnAbs, which are critical for broad virus neutralization. https://lnkd.in/gRavvyxq #bcrsequencing #immune #nextgenerationsequencing
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#VirScan® PhIP-Seq (bacteriophage-display immunoprecipitation sequencing) is a powerful method that combines DNA high-throughput sequencing with next-gen proteomics for multiplexed analysis of an individual’s antibody response to past viral exposures. Designed to target 68,000+ annotated viral protein sequences from most known vertebrate viruses, including mosquito-borne and tick-borne viral genomes, VirScan aids in understanding past infections, informing vaccination strategies, and uncovering novel biomarkers for disease detection and monitoring. Contact us today to discover the power of VirScan and see how it can transform your understanding of antibody repertories. https://lnkd.in/gk6AXFpQ #antibodies #antibody #phipseq #proteomics #monoclonalantibodies #biomarkers #diseaseresearch
VirScan™ PhIP-Seq Antibody Profiling by CDI Labs Canada
cdilabs.ca
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#Videodrop is revolutionizing the way we conduct our studies. Here’s how: 1️⃣ Analyze Large Number of Samples: Perfect for longitudinal studies and EVs production. No more limitations on the scale of your research. 2️⃣ Standardize & Normalize: Say goodbye to inconsistencies in sample preparation and testing. VideoDrop make possible side-by-side comparisons are accurate and reliable. 3️⃣ Optimize Outputs: Prepare your samples efficiently before time-intensive tests and the use of high-end instruments. Save time and resources without compromising on quality. 4️⃣ Perform Stability Study: Understand the effect of buffer and freeze-thaw cycles on your samples. Make informed decisions based on solid data. 5️⃣ Real-Time Monitoring: Keep track of isolation efficiency, experimental variability, batch-to-batch comparison, in-process controls, and yield calculation. Stay in control of your experiments at all times. #Videodrop is not just a tool, it’s a game-changer. Let’s meet during the FSEV-AFC Workshop for a demonstration!
#Myriade is participating in the first HANDS-ON WORKSHOP on “Single Extracellular Vesicles analysis” in Paris from February 7th-9th, 2024. This workshop is a joint effort by the French Society for Extracellular Vesicles (FSEV) and the Association Française de Cytométrie (AFC). Extracellular vesicles, which play crucial roles in various physiological and pathological processes, are the focus of this workshop. They are particularly important in the progression and treatment responses of several diseases, including cancers. These vesicles also have potential as non-invasive disease biomarkers. The emerging challenge in this field is the analysis of single extracellular vesicles. #Videodrop will definitively play a role ! The workshop will provide both basic and advanced technology for single extracellular vesicles analysis. It will feature lectures by international experts and hands-on practical modules led by several companies, including Myriade. #Lentivirus #ExtraCellularVesicles #LipidNanoparticles #mRNALNP #LNP #Biotechnology #CellTherapy #GeneTherapy #Bioproduction
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DNA Methylation is a key epigenetic regulator, with so many methods, it's hard to know where to start. Our Methods & Selection Guide is here...check it out! 🧬📒https://bit.ly/3NzESP7 #Epigenetics #Genomics #AACRbcd24 #Immunology
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