Cegedim Health Data’s Post

In a context of increasing diversity of RWD sources, including wearables and digital technologies that collect data passively, researchers need more discerning approaches for treating missing data than ones they’ve used in the past. The key to addressing uncertainties that arise from missing data is paying close attention to data collection methods and the intention behind why certain data are collected. This means recognising that some data are not collected by design but rather as an artefact of other, intentionally collected data. An example might be a remote monitoring device or app that collects mobility-related data (e.g., steps walked) but whose primary purpose is to monitor symptoms of dementia or atrial fibrillation. If a user incidentally turns off the mobility feature and data end up missing, this may not necessarily be cause for concern for researchers interested in the primary endpoint. As a RWD platform that focuses on *intended* data collection, Cegedim Health Data applauds a new framework for addressing challenges of missing RWD that was presented earlier this year at the annual meeting of the Professional Society for Health Economics and Outcomes Research (ISPOR). The framework lays out five key domains scientists and investigators should consider when deciding how to treat missing data. Gilles Paubert, Global Head of Cegedim Health Data #realworlddata #rwd #realworldevidence #rwe

As our screens light up with athletes giving their all, 🚀 we’re reminded of the essential sporting values of collaboration and commitment. At Cegedim Health Data, we embrace these values daily, striving to develop innovative solutions for our clients. Just as athletes constantly push boundaries to achieve excellence, we continuously endeavor to enhance our services and meet the challenges of our industry. Join our community! Subscribe now to get our latest updates and insights😊 #Innovation #Cegedim #Sport

#realworlddata #rwd #realworlddevidence #rwe

The integration of RWD, AI, and other advanced technologies is transforming the landscape of clinical trials. One of the most notable innovations it has enabled is the development of hyper-precise natural disease histories, disease models, and trial simulators. This helps researchers and operators determine optimal values for trial execution before patient recruitment begins, therefore reducing cycle times and costs. But improving trial efficiency is not the only benefit of RWD and AI integration. As the DIA Global panel discussion summary (linked below) attests, in the patient-centric era we live in, it is also critically important to improve trial design so that protocols are more attuned to patients’ experiences, needs, and preferences. For that, sponsors need insight into the patient voice – for example, by understanding ePROs in the form of social media sentiment. Advanced technologies are crucial to capturing and analyzing such evidence at scale. At Cegedim Health Data, we are fully aware of the power of patient-generated RWD and are committed to putting more of it in the hands of our valued customers – the healthcare professionals, patient advocacy groups, sponsors, researchers, and academics that turn to us for high-quality data and strategic advice. We do this by enriching our RWD-based analyses with patient voice analyses, which enables us to be an even better partner. Gilles Paubert, Global head of Cegedim Health Data #realworlddata #rwd #realworldevidence #rwe

The much-discussed European Health Data Space (EHDS) is approaching the final stages of its formalization and public launch. In this 13-minute podcast, Alexander Natz, secretary-general of the European Confederation of Pharmaceutical Entrepreneurs (EUCOPE), discusses the expected contribution by EHDS to the generation of RWD and RWE at EU level, the overreliance on clinical trials it can help avoid, and the role of the legislation as an important instrument for improving the EU biopharmaceutical sector’s competitiveness. Have a listen! Gilles Paubert, Global Head of Cegedim Health Data #realworlddata #rwd #realworldevidence #rwe

RWD and RWE have many advantages for organisations that leverage them to their full potential, but also some disadvantages. One of the biggest drawbacks is the varying acceptance of RWE as “legit” evidence due to the role of unmeasured confounders. In the fall of 2022, PhRMA and BIO conducted a workshop on the subject of unmeasured confounders. A report that captures the main themes and learnings from the workshop has just been published and includes a discussion of novel methodologies for addressing the issue. One of the most interesting aspects of the report is the discussion around fit-for-purpose, research-grade RWD that needs to be intensively curated before being transformed into high-quality, trustworthy evidence generation (pages 11-12 in the report). At Cegedim Health Data, this is our “specialty of the house” and we take pride in carefully aggregating and prepping data before making it available to researchers in industry, healthcare, and academia. Gilles Paubert, Global Head of Cegedim Health Data #realworlddata #rwd #realworldevidence #rwe

Among its many uses and applications, RWD is critical for identifying optimal second-line and combination therapies when a first treatment for hypertension is not enough to control the disease. This is the thesis of a research project recently launched by the Yale School of Medicine and supported financially by the U.S. National Institutes of Health. Conducting RCTs for understanding the most effective secondary therapies or the precise combination of antihypertensive therapies that are most suitable for patients with different characteristics and to compare every possible drug and combination would be incredibly time-consuming and costly but gleaning such information retrospectively is more efficient with RWD collected while treating such patients. RWE-informed clinical guidelines that factor in the interplay between different secondary therapies and patient subgroup characteristics should be developed based on those insights, the project’s leader, Yuan Lu, says. While Yale is far away from the EU and from Cegedim Health Data’s network of data provider sites, what unites us is that the prestigious university’s research uses the OMOP Common Data Model, just as we do when curating and pre-processing the RWD we make available with THIN® databases. Gilles Paubert, Global Head of Cegedim Health Data #realworlddata #rwd #realworldevidence #rwe

The capabilities of real-world data and real-world evidence to generate critical insights for life sciences, care delivery, and research organizations are driving constant innovation in how these assets are being applied and the benefits they unlock for users and patients. However, while we focus our attention on the advances being made, we rarely stop to think about the individuals working behind the scenes and driving the RWD/RWE field forward. Helga Gardarsdottir, who together with her team at Utrecht University is developing new methods for RWD analysis at European level, is one of those people. We celebrate her dedication to the field and her recent appointment as professor of RWD for decision-making on medicines. In the article below, she shares her thoughts on some nuanced questions about RWD and their implications for patients. Gilles Paubert, Global Head of Cegedim Health Data #realworlddata #rwd #realworldevidence #rwe

We all know about the benefits of RWD and clinical trial data: one category complements the other, while each individually offers distinct insights to providers, payers, and sponsors. But do we know enough about the unique challenges life science companies face when trying to integrate RWD data with their own trial data for a more holistic understanding of investigational therapies and the multiple use cases they may serve? Through our proprietary data centres in France and elsewhere and our sovereign cloud solution, Cegedim Health Data offers an answer to one of the main data integration constraints for pharma companies – the issue of data access and storage. Gilles Paubert, Global Head of Cegedim Health Data #realworlddata #rwd #realworldevidence #rwe

[REPLAY] 📢 Data and Population Health Management in France 👉 Check out the round table* organized by Bpifrance, Banque Publique d’Investissement and numeum, the French digital sector’s union, at SantExpo** last month.   🔎 Topics covered include: ✅ How to transform the healthcare system? ✅ Can England’s Integrated Care System model be applied in France? ✅ Which data should be used to monitor population health? ✅ How can population health solutions be deployed?   Access the recording here: https://lnkd.in/gY-tceRA   These experts shared their insights: ✅ Sébastien Massart, Dassault Systèmes ✅ Franck Le Ouay, Lifen ✅ Sherley Brothier, CTO Softway medical ✅ Gilles Paubert,  Cegedim Health Data The event was moderated by Christophe Clement-Cottuz, SBA_Smart Building Alliance   #RWD #RWE #RealWorlddata #RealWorldEvidence #PopulationHealthManagement   *Content in French only **Santexpo is a leading annual event organized in France by the French Hospital Federation. It brings together decision-makers and healthcare professionals who are involved in care pathways and patient experience in healthcare and medico-social establishments, and also help manage, administer, digitalize, equip, build, and transform them.