Cell & Gene Therapy Insights’ Post

If you are planning on attending #OCTWestCoast next week, be sure to swing by and listen to my fantastic colleague Patty talk about how #realworlddata, #realworldevidence and #AI can already and might in the future help address some of our biggest challenges with long term follow up in #cellandgenetherapy trials. #iconplc #biotech #cellandgenetherapy

🙌 Discover how the collaboration and sharing of expertise between BD and Cell and Gene Therapy Catapult helped to advance #flowcytometry panels to support QC of manufacturing process optimisation in the #PATconsortium. 👉 https://bit.ly/3Rc1XK4 #CAR-T #CellTherapy #GeneTherapy #ATMPs #AdvancedTherapies #TCells

🚀ISCT, International Society for Cell & Gene Therapy 📅 May 30, 12:30 PM - 12:45 PM 📌 Exhibit Hall - Theatre A Do not miss the opportunity to visit my presentation during the #ISCT2024 in Vancouver: 𝗘𝗻𝗴𝗶𝗻𝗲𝗲𝗿𝗲𝗱 𝗜𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝗼𝗻: 𝗧𝗵𝗲 𝗠𝗮𝗸𝗶𝗻𝗴-𝗢𝗳 𝗗𝗘𝗡𝗔𝗥𝗔𝗦𝗘 𝗛𝗶𝗴𝗵 𝗦𝗮𝗹𝘁 𝗳𝗼𝗿 𝗛𝗶𝗴𝗵-𝗘𝗳𝗳𝗶𝗰𝗶𝗲𝗻𝗰𝘆 𝗗𝗡𝗔 𝗥𝗲𝗺𝗼𝘃𝗮𝗹 𝗶𝗻 𝗩𝗶𝗿𝗮𝗹 𝗩𝗲𝗰𝘁𝗼𝗿 𝗠𝗮𝗻𝘂𝗳𝗮𝗰𝘁𝘂𝗿𝗶𝗻𝗴 👇Session Objectives: 🌱 Enzyme engineering at c-LEcta: ENESYZ Technology Platform 🔍 How to improve efficiency of viral vector manufacturing at elevated salt concentrations ✅ The benefits of DENARASE High Salt for DNA removal 📢 Stop also by 𝗕𝗼𝗼𝘁𝗵 𝟰𝟭𝟰 to talk to my colleagues Svenja Michalek & Melissa Rangel who will tell you more about 𝗗𝗘𝗡𝗔𝗥𝗔𝗦𝗘 𝗛𝗶𝗴𝗵 𝗦𝗮𝗹𝘁 and our complete toolkit for DNA removal. #CGT #DENARASE #biopharma #ISCT2024 #enzyme #endonuclease #viralvector #bioprocessing

AAV gene therapy researchers are constantly seeking methods to design vectors that demonstrate enhanced manufacturability by minimizing truncations. In a simulation experiment comparing two vectors featuring the same Gene of Interest (GOI) but employing different promoters, FORMsightAI accurately predicted the higher performing promoter. This was subsequently validated through NGS data analysis. Download the latest report on our biological validation studies to explore how AI is now improving key vector design outcomes. https://hubs.li/Q02rcjl20 #AI #NGS #vectordesign

Learn how a publicly traded gene therapy company struggled to identify an optimal vector design to carry forward after 15 rounds of empirical optimization over three years. By applying AI/ML models, Form Bio was able to identify four optimal vector designs within days that resulted in 91% full capsids. The company was able to advance a lead and backup candidate to next steps. Explore the methods and results: https://hubs.li/Q02LwKgs0 #VectorDiscovery #AAV #GeneTherapy #InSilico

Highly accurate determination of the AAV vector content and genome length distribution, with our 𝟯𝗿𝗱 𝗚𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝗼𝗻 𝗔𝗔𝗩 𝗮𝗻𝗮𝗹𝘆𝘀𝗶𝘀!

Do not miss Vincenzo Di Cerbo, Lead Scientist at the Cell and Gene Therapy Catapult, at ISCT, International Society for Cell & Gene Therapy's 30th Annual Meeting in #Vancouver! Vincenzo will be chairing the roundtable "Enabling Patient Access: Identifying Disruptive Technologies in CGT" on 30th May discussing underdeveloped technological areas, and recognising if trends in technology investments match high-potential areas. Learn more: https://buff.ly/3vPGTSr #AdvancedTherapies #PatientAccess #CellTherapies

Only a week to go until the Cell and Gene Therapy Catapult are speaking at the Economist Impact's 2nd Annual Cell and Gene Therapy Summit in #Brussels, Belgium! Our speakers will be sharing expert commentary across the two-day event on investors' insights into #CGTs, scaling manufacturing, and how can the #AdvancedTherapies industry ensure a reasonable return? Don't miss your chance to hear from us: https://buff.ly/3PfTHHW #Manufacturing #Investors #CellTherapies

🔬 Revolutionizing gene therapy, our 𝟯𝗿𝗱 𝗚𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝗼𝗻 𝗔𝗔𝗩 𝗮𝗻𝗮𝗹𝘆𝘀𝗶𝘀 offers rapid insights into transgene incorporation efficiency for AAVs. Going beyond old generation methods, the 3rd Generation AAV analysis can accurately and objectively determine vector content (percentage of empty and filled particles) and distinctly identify different intermediates! The method also provides the genome length distribution of the entire AAV sample. This transformative technology delivers precise measurements, unveiling crucial details about transgene incorporation efficiency. 🚀💡 Stay at the forefront of gene therapy with our groundbreaking approach. 💪🧬 Contact info@qutem.com for more. #QuTEM #lifescience #genetherapy #innovation #aav

🚀 **Insight into Cell and Gene Therapy!** 🚀 Industry leaders discuss the evolving landscape of cell and gene therapy, highlighting the challenges in manufacturing and the necessity of better communication and digital tools. Key takeaways include the importance of adapting traditional processes and leveraging technology to enhance patient outcomes and navigate this multi-stakeholder environment. Stay ahead in personalized medicine by understanding these critical insights and the future of CGT! #CellAndGeneTherapy #PersonalizedMedicine #DigitalTransformation #HealthcareInnovation https://deloi.tt/3SdCd0D