Center for Precision Medicine’s Post

Diabetes and blood lipids --- Early and precise identification of high-risk individuals for Type 2 Diabetes (T2D) and Cardiovascular Disease (CVD) is not merely beneficial but critical for effective management. We published an article describing the intricate interplay of genetic, lipidomic, and clinical factors in developing better risk assessment. Lipidomics data clustering identifies subgroups, each carrying a different disease risk score. The highest-risk subgroup, while not dramatically different in vital parameters, shows a distinct lipidome signature. This underlines the urgency of regular lipidome monitoring for risk evaluation. Early identification of lipidomic alterations not only enables timely interventions but also offers an opportunity to reshape lifestyles and dietary habits for future disease prevention. Read the article here: https://lnkd.in/eeMw5zt9 #HealthResearch #PublicHealth #research #lipid #lipidomics #LipidMetabolism #lipotype #lipidome #diabetes

*Metabolic-associated fatty liver disease (MAFLD):* According to doctors at the Institute of Liver and Biliary Sciences (ILBS), who surveyed more than 6,000 people, 56% of the study population were found to have MAFLD. Though most of them were found to be overweight/obese, 11% were lean or had normal weight. MAFLD refers to a build-up of fat in the liver, in addition to one or more metabolic risk factors such as overweight/obesity, Type-2 diabetes, raised cholesterol in blood and metabolic dysregulation among others.MAFLD is a non-alcoholic fatty liver disease, scarring or permanent damage of the liver, liver cancer, and ultimately premature death. Fatty liver precedes high cholesterol, diabetes, high blood pressure and other non-communicable diseases by 10-15 years. By preventing and reversing fatty liver, we could reduce this burden in a decade. Lower than ideal weight, exercise, time-restricted eating and preventing childhood obesity could reduce the risk of MAFLD.(Courtesy ILBS) #fattyliverdisease #liver #obese #fat #type2diabetes #cholesterol #livercancer #hypertension #MAFLD #ilbs #timerestrictedeating

Article on Hepatomegaly🫥 HEPATOMEGALY An enlarged liver is one that's bigger than normal. Rather than a disease, an enlarged liver is a sign of an underlying problem, such as liver disease, congestive heart failure or cancer. Treatment involves identifying and controlling the cause of the condition. The liver typically extends from the fifth intercostal space to the right costal margin in the midclavicular line. By ultrasound, a normal liver span is usually <16 cm in the midclavicular line; however, liver size varies with sex and body size Causes Alcohol use (especially alcohol abuse) Cancer metastases (spread of cancer to the liver) Congestive heart failure Glycogen storage disease Hepatitis A Hepatitis B Hepatitis C Hepatocellular carcinoma Signs and Symptoms Fatigue Nausea or lack of appetite Jaundice (yellowing of the skin and eyes) Dark-colored urine and light-colored stools Itchy skin (pruritis) Enlarged spleen (splenomegaly) Abdominal pain Fatigue Nausea and vomiting. Management Making dietary changes, including reducing the intake of cholesterol and fats. Reaching or maintaining a moderate weight. controlling blood sugar levels. Managing underlying health conditions, such as type 2 diabetes. If it's the result of chronic liver disease, it can potentially be reversed and in some cases cured with lifestyle changes. #snsinstitutions #snsdesignthinkers #designthinking

**Global Fatty Liver Day: Unveiling the Hidden Epidemic** As the world observes Global Fatty Liver Day, it's crucial to shed light on the often-overlooked condition of Non-Alcoholic Fatty Liver Disease (NAFLD) and its more severe form, Non-Alcoholic Steatohepatitis (NASH). These liver conditions, characterized by excessive fat accumulation, can progress to serious complications like cirrhosis and liver cancer if left unchecked. The day serves as a reminder of the importance of early detection and intervention. Regular screenings and lifestyle modifications play a pivotal role in managing and potentially reversing the disease. With the rise in obesity and diabetes, the prevalence of fatty liver disease is increasing, making public awareness and education more important than ever. As we mark this day, let's commit to better liver health through informed choices and proactive healthcare measures.

#Inflammation Inflammation viewed on both sides is a healing process (Acute) and can as well be an indication of unresolved (chronic) infection/injury/irritation of the affected cells/tissues. Real promoters of chronic inflammation include: - Bacteria - Viruses - Parasites. - Uncontrolled inflammatory cytokines. Inflammation is among the underlying causes of: - Dementia. - Obesity. - Diabetes mellitus. - Cardiovascular diseases. - Poly myalgia - Cancer. Risk factors include: - Increased levels of LDL and low HDL. - Insulin resistance. Intervention: - Quit smoking. - Use of professional prescribed Low Carb High fat diet. NB:- Different people of different ages and unique needs must seek guidance of a qualified clinical nutritionist before starting the LCHF diet program. Ketones acquired in the diet reduces fatty acids and inflammatory markers associated with fat loss, increase glycemic control, boosts insulin sensitivity and triglycerides+ HDL. Eat well, lead a quality Life 😉 Keep in touch to learn More. Engage for professional assistance/intervention.

🧠✨ #TeachingTuesday: Understanding PCOS and NAFLD NAFLD (Nonalcoholic Fatty Liver Disease) is the most common chronic liver disease globally. Shockingly, up to 70% of women with PCOS also have NAFLD. Most people don't know they have NAFLD, so seeing a provider who can diagnose it is crucial. Risk Factors: 1️⃣ Hyperandrogenemia 2️⃣ Chronic low-grade inflammation 3️⃣ Genetic factors 4️⃣ Hypertension 5️⃣ Dyslipidemia 6️⃣ Larger-than-average waist size 7️⃣ Type 2 diabetes 8️⃣ High cholesterol 9️⃣ High triglycerides Untreated NAFLD can lead to severe complications like nonalcoholic steatohepatitis and advanced liver fibrosis, potentially resulting in liver-related mortality. Managing NAFLD: 1️⃣ Lifestyle modifications 2️⃣ Insulin sensitizers 3️⃣ Glucagon-like peptide-1 agonists 4️⃣ Bariatric surgery 5️⃣ Fish oil supplements: Omega-3s help reduce inflammation, triglycerides, and insulin in women with PCOS. A study found that 4 grams of fish oil for eight weeks significantly reduced liver fat and triglycerides. Take charge of your health! 🌟 #PCOS #NAFLD #TruePhoenixCommunityCare #HealthTips #WomensHealth #TruePhoenix #PCOSTips #GutHealth #ManagePCOS #HealthEducation #TeachingTuesday #NursePractitioner #RootCauseNP #GutHealthNP #WeightLossJourney #PCOSSpecialist #PCOSAwareness #ParkvilleMD #Maryland #DrBNP

It was very interesting to attend today the webinar “Obesity: understanding the disease, nutritional approaches and new pharmacological interventions” organized by the International Pharmaceutical Federation (FIP). Obesity is recognized as a significant public health hazard, as it increases the risks for multiple diseases, such as type II diabetes, cardiovascular disease, hyperlipidemia, hypertension, stroke, breast and colon cancer, and degenerative arthritis. Over the past 50 years, worldwide obesity have tripled, creating a public health crisis so widespread and damaging that it is sometimes referred to as an epidemic. The most important strategies for preventing obesity are healthy eating behaviors, regular physical activity, and reduced sedentary activity.

Alterations of oral and gut viromes in hypertension and/or periodontitis https://lnkd.in/gjA5rQu3

Some studies have found that an infection of a small number of hookworms (a nematode parasite usually transmitted by the soil) actually improves metabolic health. As a parasitology enthusiast, I seriously doubt this would be a way forward to cure such health problems, as the worms potentially cause other issues. But I do appreciate the last sentence in this article. "Also, if we can learn more about what hookworms release into the body to influence metabolism, we may be able to design protein-based treatments that mimic the effect of the live worm." https://lnkd.in/g6rpMMCz

June 13th is Global Fatty Liver Day (formerly International NASH Day) with the campaign theme “Act Now, Screen Today.” It is important to reduce the impact of this silent epidemic affecting 1 in 3 adults worldwide to prevent progression to chronic liver disease, cirrhosis and cancer. Appropriate and timely screening could reduce impact caused by fatty liver and its association with metabolic syndrome, obesity, diabetes, hypertension and abnormal cholesterol levels. HepQuant is committed to bring awareness about liver health by providing first in kind non-invasive quantitative liver function test. HEPQuant – Transforming Liver Health #GlobalFattyLiverDay #hepaticsteatosis #NAFLD #MAFLD #ChronicLiverDisease #Obesity #Diabetes #HepQuant #HepQuantDuO