Time again for our #ImageOfTheWeek! This week’s image is a CD138 Expression in Inflammatory Bone Marrow! This protocol is used to detect plasma cells in bone marrow samples in Phase 1, Phase 1/2, and Phase 2 clinical studies. Thanks to Alexy Promonet for creating this image! Want to discover more? You can already have a sneak peek at our Art of Histopathology book: https://lnkd.in/emRtqNGV #TransformingResearch #AdvancingHealth #Histopathology #IHC
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𝐀 𝐏𝐫𝐨𝐟𝐞𝐬𝐬𝐢𝐨𝐧𝐚𝐥 𝐏.𝐇.𝐃. 𝐡𝐨𝐥𝐝𝐞𝐫 𝐰𝐡𝐨'𝐬 𝐬𝐩𝐞𝐜𝐢𝐚𝐥𝐭𝐲 𝐢𝐬 - 𝗠𝗲𝗱𝗶𝗰𝗮𝗹 𝗗𝗲𝘃𝗶𝗰𝗲𝘀 | 𝗕𝗶𝗼𝘁𝗲𝗰𝗵 | 𝐌𝐞𝐝𝐢𝐜𝐢𝐧𝐞𝐬 | 𝗟𝗶𝗳𝗲 𝗦𝗰𝗶𝗲𝗻𝗰𝗲𝘀 | 𝗛𝗲𝗮𝗹𝘁𝗵𝗰𝗮𝗿𝗲 | 𝗣𝗵𝗮𝗿𝗺𝗮
𝐎𝐧𝐞 𝐨𝐟 𝐭𝐡𝐞 𝐦𝐨𝐬𝐭 𝐝𝐞𝐭𝐚𝐢𝐥𝐞𝐝 𝐦𝐨𝐝𝐞𝐥𝐬 𝐨𝐟 𝐚 𝐡𝐮𝐦𝐚𝐧 𝐜𝐞𝐥𝐥 𝐨𝐛𝐭𝐚𝐢𝐧𝐞𝐝 𝐮𝐬𝐢𝐧𝐠 𝐗-𝐫𝐚𝐲, 𝐍𝐌𝐑, 𝐚𝐧𝐝 𝐜𝐫𝐲𝐨𝐞𝐥𝐞𝐜𝐭𝐫𝐨𝐧 𝐦𝐢𝐜𝐫𝐨𝐬𝐜𝐨𝐩𝐲: 📚 𝐃𝐨𝐧'𝐭 𝐌𝐢𝐬𝐬 𝐎𝐮𝐭 𝐎𝐧 𝐘𝐨𝐮𝐫 𝐏𝐃𝐅 𝐁𝐫𝐨𝐜𝐡𝐮𝐫𝐞: https://lnkd.in/d95dGhdQ Organelles are structures within cells that perform specific functions, similar to how organs in an organism serve specific functions to maintain life. Among the more important cell organelles are the nuclei, which store genetic information; mitochondria, which produce chemical energy; and ribosomes, which assemble proteins ✦ 𝑯𝒆𝒓𝒆 𝒚𝒐𝒖 𝒄𝒂𝒏 𝒇𝒊𝒏𝒅 𝒖𝒏𝒊𝒒𝒖𝒆 𝒊𝒕𝒆𝒎𝒔: https://lnkd.in/d95dGhdQ Credit: Evan Ingersoll & Gael McGill #neuroscience #biology #medicine #cell #celltherapy
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Have you wondered about what you can do with super-resolution #microscopy and how it works lately? Check out our new Super-Resolution Microscopy FAQ webpage where experts answer many of the questions researchers come across while using this technology. Learn more about the common technique called single molecule localization microscopy (SMLM) and how to apply it your research! 🔎 https://lnkd.in/gXcDZ6cC #neuroscience #cellbiology #genomics #DNA #Nanoscale #SMLM
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It has been a little over a year that I have left the wet lab and as I was going through some of my old data, I found these beautiful images I took when testing different antibodies. Indeed, #histology and #microscopy for me are the techniques that result in the most beautiful results. Here you can see a part of a mouse prostate that has been stained with three different antibodies and DAPI. #Science #staining #antibodies #fluorescence
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Utilize the cutting-edge capabilities of Akoya Biosciences' PhenoCycler Fusion System for multiplex immunofluorescence. This sophisticated system not only guarantees top-tier imaging quality but also incorporates automated cycling for staining, viewing, characterizing, and quantifying 100+ biomarkers in a single sample. 🧬 Effortlessly delve into intricate details, analyze each cell, and reveal unbiased discoveries. #histology #histopathology #Akoyabioscience #immunofluorescence #cancerresearch #invivo #multiplexing #pathology See More: https://lnkd.in/exFbGp-r
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Student at Dr. Vikram Sarabhai Institute of Cell & Molecular Biology, The M. S. University of Baroda 📚 🧬🔬
Hey LinkedIn! If you’re new to following me, I talk about #ScienceResearch #Biotechnology #LifeSciences #CellBiology #MolecularBiology #Research #StemCells #NeuroScience #OncologyResearch #Genomics #CellTherapy #GeneTherapy and #Genetics Let me know which topic interests you the most & also let me know if you have any suggestions on what to share! ✒️
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Bio-protocol's latest issue is now live! https://lnkd.in/gYXdeH-M Dive in and discover various insightful protocols on #cellbiology, #microbiology, #neuroscience, and #stemcells On the cover: Quantitative bioimaging of host and parasite nascent proteomes during Plasmodium berghei liver stage development. The nascent proteome of P. berghei-infected HepG2 cells (pseudo-colored red) visualized using o-propargyl puromycin conjugated to alexaFluor555 following 4-hr treatment with a parasite selective translation inhibitor (shown on the right) and DMSO control (shown on the left). Single channel images of parasite cytoplasmic marker (PbHsp70, shown in green) and Hoechst labeled DNA (shown in blue) are used for image segmentation and masking to define the parasite objects and HepG2 nuclei objects, where the fluorescence intensity of the labeled HepG2 and Plasmodium nascent proteomes are quantified. Find more details about this protocol by James McLellan, Andreu G., and Kirsten Hanson at The University of Texas at San Antonio: https://lnkd.in/gxkw9qk6 Do you have a protocol that can contribute to scientific clarity and reproducibility ? Visit us at https://lnkd.in/dt_igxRi and explore publishing with Bio-protocol at https://lnkd.in/gR3QGYz6! #openaccess #reproducibility #lifesciences #research
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HPFs have been underestimated for decades and now are at risk of being overestimated! Check out this insightful work published on Pathologica for an in-depth explanation. #Pathology #PathologyInnovation Luca Cima
How many mm² are in a HPF under your microscope? And does it really matter? Check out Dr. Salvatore Lorenzo Renne work on #Pathologica to find out more: https://lnkd.in/d4fcg8Cw With well-written and free article that are useful in daily diagnostic routine, #Pathologica is a versatile journal, projected into the future without forgetting the past. Find more interesting articles on our website: https://lnkd.in/dYXxbgs7 #pathology #histopathology #diagnostics #pathologist #microscopy #microscope #surgicaloncology #cytology #pathologylab #pathologyinnovation
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Vampire viruses prey on other viruses to replicate themselves and may hold the key to new antiviral therapies, written by Ivan Erill Click to read the full article! https://lnkd.in/eHpBt_62 . #UMBC #UMBCbiology #biology #science #bioscience #retrievernation #genetics #physiology #phagehunters #DrosophilaNeuro #cellmigration #biomedical #CNMS #STEM #WomenInSTEM #biochemistry #neuroscience #appliedmolecularbiology #bioinformatics #biomedicalsciences #systemsbio #genomics #ASPB #matechoice
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An all-too-common challenge in tissue section quality control (QC) is having an insufficient sample size. This can be a showstopper for a study. For reliable data: 📏 Ensure there's enough viable tissue area for analysis. For large sections, aim for no less than 1.0 mm². 🎯 When focusing on a specific region of interest (ROI) like tumors, there should be ample area present for precise quantification. Without sufficient biomarker quantification within a section, confidence in making judgments on the difference between samples would be hampered. 𝗪𝗵𝗮𝘁 𝗼𝘂𝗿 𝘀𝗰𝗶𝗲𝗻𝘁𝗶𝘀𝘁𝘀 𝘀𝗮𝘆: "It's not just about capturing an image but ensuring its quality. While it might seem evident, prioritizing this step is crucial. A variety of methods can assess image quality, underscoring the importance of rigorous QC in every image analysis phase." If you need support with your projects or need advice on image analysis quality control, don't hesitate to get in touch and arrange a chat with our experts! —— #digitalpathology #computationalpathology #histopathology #pathology #imageanalysis #biomarkers PS. Follow us OracleBio for more image analysis tips, insights, and the latest research from our image analysis scientists.
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Until recently, about half of the human Y chromosome was missing from the reference genome. Now, researchers have completed the sequence. https://ow.ly/a2mt50PEFVc #EMShasit #chemistry #histology #biology #cryo #fluorescence #electronmicroscopy #genetics #microscopy #microtomy #imaging #pathology #neuroscience #pharmaceuticals #laboratory #research #specimen #labsupplies #labsafety #TEM #SEM
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