Constantiam Biosciences’ Post

In a recent highlight from our webinar, "Unlocking Genetic Causes of Sudden Cardiac Death with Scalable Assays of Variant Effect," Dr. Victoria Parikh provided an insightful answer to an important question about utilizing assays of variant effects To hear Dr. Parikh's response and explore more about how scalable assays are transforming our approach to cardiac genetics, click the link to view the entire session. Don't miss these expert insights into advancing precision medicine in cardiology! Watch the Full Webinar Here: https://lnkd.in/d5BFGbn3 #CardiacGenetics #PrecisionMedicine #Webinar #MAVEvidence #ConstantiamBiosciences #polygenicconditions

🔬Unlocking new frontiers in #CardiologyResearch! Our latest article in Exploration of Cardiology reveals groundbreaking findings: SGI-1027-loaded nanoparticles effectively reduce atherosclerosis in mice and curb inflammation in human macrophages.  A game-changer in epigenetic therapy!  🧬 #Atherosclerosis #Nanotechnology #Epigenetics" 🔗https://lnkd.in/gu9J2d-c

We’re still in the early stages of understanding the underlying genetics of AFib, but there is increasing recognition that genetic culprits for ventricular cardiomyopathies and arrhythmia syndromes might initially present with AFib. A recent, trailblazing white paper delves into this area of research, exploring how genetic testing could help screen for these life-threatening conditions in patients with early onset AFib. Read the full report in the Canadian Journal of Cardiology: https://lnkd.in/gQwvxDM5 #AtrialFibrillation #AFib #Cardiology #WhitePaper

Excited to share that a paper stemming from my PhD project, titled "BDNF sensitizes bone and joint afferent neurons at different stages of MIA-induced osteoarthritis", has been published in Bone Journal. This work was supported by funding from the Australian National Health and Medical Research Council (NHMRC) and the University of Melbourne School of Biomedical Sciences Early and Mid-Career Association Collaborative Research Award. Our research sheds light on the critical role of BDNF/TrkB signaling in osteoarthritis (OA) pain. By demonstrating that TrkB is expressed in neurons innervating the knee joint and bone, and that BDNF application enhances their mechanical sensitivity, we provide valuable insights into the mechanisms underlying OA pain. Additionally, our findings reveal how BDNF expression changes throughout the disease progression, suggesting a potential therapeutic window for intervention. Importantly, TrkB inhibition effectively reverses sensitivity alterations at different stages of OA, indicating that targeting this pathway could offer new strategies for managing OA pain and improving patients' lives. I’d like to thank everyone who contributed to this work. Your insights were invaluable! Looking forward to your thoughts and discussions! #Osteoarthritis #Pain #Nociceptive_pain #Nociceptors #Sensory_neurons #BDNF #TrkB #Joint #Bone #Research #Publication #Neuroscience #Neuroinflammation https://lnkd.in/gq-REACb

With such a rapid rate of advancement for pharmacologic therapies in cardiometabolic syndromes, conversations on the safety and efficacy of combination therapy have risen to the forefront of discussions. At #ESCCongress, we sat down with Brendon L Neuen, MBBS, PhD, of The George Institute for Global Health and Royal North Shore Hospital, to discuss a study he led examining the topic of combination GLP-1 RA and SGLT2 inhibitor use on cardiovascular and kidney outcomes in people with #Type2Diabetes using data from FLOW, Harmony Outcomes, and AMPLITUDE-O. https://lnkd.in/eX2_SXa3 #Cardiology #Nephrology

Brown tumors (BTs) are benign, lytic lesions that result from long-standing untreated hyperparathyroidism. BTs as the initial manifestation of primary hyperparathyroidism are rare, especially in developed countries. The main differential diagnosis is of a giant cell lesion, which shares the same clinical, radiological, and histological features as BT. It is important to distinguish between these two bone pathologies in view of different treatment strategies; BTs often respond to correction of long-standing hypercalcemia whereas giant cell lesions often require surgical removal. Source: Internet Submissions are open for upcoming issue! Submit your attachment to editor.endocrinology@maplejournal.com Visit journal's website for more information: https://lnkd.in/gegq8Yd Follow us: https://lnkd.in/dR9gSmX5 #browntumors #endocrinologgy #giantcell #benign #diagnosis #hypercalcemia #pathology #bones #research #histology #hyperparathyroidism #radiology #treatment #metabolism #lytic

https://lnkd.in/gYaKJyKD Article title: Is TI-RADS classification and Score Modified Method of thyroid nodules can be effective for evaluation of Thyroid Incidentalomas on FDG PET-CT imaging Author(s): Pelin Ozcan Kara; Zehra Pinar Koc; Yüksel Balci; Rabia Bozdogan Arpaci Journal: Open Journal of Thyroid Research Journal ISSN: 2640-7981 Abstract Background: Flourodeoyglucose Positron Emission Tomography-Computed Tomography (FDG PET-CT) provides information about the anatomic structures and metabolic activities of tumors. The incidence of thyroid incidentaloma is rare on FDG PET-CT but it is related to malignancy when it is detected to be high. Although, patients who are already treated with another primary tumor can not be searched for second thyroid malignancy each time. The aim of this study was to evaluate TI RADS classification based on a score modified according to ultrasound (US) criteria for malignancy of thyroid nodules determined on FDG PET/CT imaging. #PETCT #Incidentoloma #TIRADS #Hyperthyroidism #Thyroiditis #ThyroidCancers #NoncancerousNodules #ThyroidFunctionTest #SignificanceOfIodine #ClinicalSignificance #CongenitalAnomalies #DiseasedThyroids #EmbryologicalAndFetalDevelopment #EnlargedThyroid #Histology #Hypothyroid #OtherDisorders #OveractiveThyroid #Parathyroid #Physiology #Radioiodine #ThyroidCondition #SymptomsOfThyroid #Peertechz #PeertechzPublications #OpenAccess #ScientificJournals #PeerReviewedJournals #OpenAccessPublishers #T3AndT4Production #T3AndT4Regulation #ThyroidDiseaseSymptoms #ThyroidDisorder #ThyroidGland #ThyroidHormones

🔬 Inside the Brain: The Pathology of Alzheimer’s Disease 🔬 Alzheimer’s disease is marked by specific changes in the brain, including the buildup of amyloid plaques and tau tangles. These changes disrupt brain function, leading to the symptoms we associate with Alzheimer’s. Understanding the underlying pathology is crucial in the fight against this disease. This video created by the National Institute on Aging explains how Alzheimer’s changes the brain: https://lnkd.in/eV65HgA #AlzheimersPathology #BrainHealth #AlzheimersResearch #WorldAlzMonth #CUAnschutz

💡 Did you know? A recent scientific statement from the American Heart Association highlights that CYP2C19 genotyping for guiding antiplatelet therapy not only reduces the risk of recurrent ischemic events but is also highly cost-effective. (1) Studies evaluating clinical event rates and medical costs have shown that CYP2C19 genotyping for ACS patients undergoing PCI is notably cost-effective, both in the United States and internationally, especially compared to the universal use of ticagrelor or prasugrel. (1) Additionally, authors noted this approach is also cost-effective for treating acute strokes and high-risk transient ischemic attacks. (1) 🧬Find out how the rapid FDA-cleared and CE marked Genomadix CYP2C19 test can help clinicians optimize oral #P2Y12 treatments while saving costs! Visit www.genomadix.com to learn more. 1. Pereira et al., Circulation. 2024;149. DOI: 10.1161/CIR.0000000000001257   European Stroke Organisation  #Pharmacogenetics #PrecisionMedicine #Pharmacogenomics #biotechnology #neurology #cardiology #healthcare #stroke #StrokeAwareness #StrokePrevention #OptimizedDAPT #DAPT #AntiplateletTherapy #ticagrelor #prasugrel #clopidogrel #antiplatelet #genotyping #genetictesting

### The Revolutionary Field of Organoids Organoids, miniature 3D structures grown from stem cells that mimic the organization and function of real organs, are transforming biomedical research. These tiny, lab-grown organ models provide an unprecedented window into human development, disease progression, and drug responses. Recent advancements include the creation of brain organoids to study neurological diseases, and gut organoids to investigate digestive disorders. Notably, organoids have been used to model COVID-19 infection pathways, aiding in the rapid development of treatments. This cutting-edge field bridges the gap between in vitro studies and human physiology, offering promising avenues for personalized medicine. #Organoids #BiomedicalResearch #PersonalizedMedicine