Cour Pharmaceuticals Development Co., Inc.’s Post

🔬🧬 Delving into the latest advancements in immunology, the recent publication in Frontiers in Immunology sheds light on how molecular antibody biology and structural protein engineering are revolutionizing the field. The study explores the intricate modifications of IgG antibodies, aiming to boost their therapeutic potential. Key areas include glycosylation, allotypic variation, Fc engineering, and Fc gamma receptor binding optimization. This research is a leap forward in understanding and enhancing the efficacy of antibody-based therapies. 🌐🔍 #Immunology #ProteinEngineering #Therapeutics #AntibodyResearch #Biotechnology Timon Damelang Maximilian Brinkhaus Thijs van Osch Janine Schuurman Aran Labrijn Theo Rispens Gestur Vidarsson

Very comprehensive and insightful summary for the T-cell dysfunctions. We may need to consider that post translational modifications (PTMs) are involved in all the cases of T-cell dysfunction, in this case, methylation. PTM may have signaling roles of initiation and termination to functional proteins, eventually to cells. It is interesting that Th17 cells succeed baton from Treg in case of instability via RORrt. Indeed the roles of FOXO3 are also interesting because they will have lots of potentials of transcriptional activities. In this article, we may need to consider three chimeric factors (PTM, FOXO3 and RORrt) for maximizing T-cell therapies.

Check out my new paper published in Frontiers in Immunology! Thanks to everyone involved in getting this out! https://lnkd.in/ejSAyEDu

Webinar Part 6 | Advantages of Fluorescence in Cell Counting How does AO/PI work for measuring cell viability? In this clip, learn from Dan about how Acridine Orange and Propidium Iodide fluorescence dyes work together to determine viability. Watch the full webinar now: https://buff.ly/3DaBepP #LifeScience #Laboratory #Microbiology #CellBiology #CellCulture #LaboratoryEquipment #Immunology #CancerResearch #FlowCytometry #Webinar

Nice work by our team showing how the engineering of therapeutic antibodies with AMFA analogues allows for targeted degradation of the antigen and increased therapeutic efficacy

Wednesday at #ACR23: Apply lessons from COVID-19 to improve your understanding of genetic influence on immunology. Read a preview in ACR Convergence Today → https://acr.tw/3MD4qep

Inflammation models, reflecting crucial pathological aspects of human diseases, serve as a comprehensive platform for advancing preclinical drug development. The ability to assess therapeutics from ex vivo models through to more intricate in vivo models represents an essential tool in modern drug discovery. Join Karl & Esther at the upcoming British Society for Immunology conference where they will share two posters detailing this robust translational approach utilising LPS models of inflammation. Dr Karl Deacon exemplifies our capabilities in studying anti-inflammatory compounds, transitioning seamlessly from human/murine ex vivo tissue to murine in vivo models of inflammation. Dr Esther Mokori showcases our utilization of the murine LPS model to evaluate a spectrum of drugs targeting diverse components of the inflammatory pathway, as an effective PK/PD platform for evaluating inflammatory mechanisms in disease. These assays further amplify our translational platforms, contributing to informed decision-making in the development and evaluation of novel systemic and neurological anti-inflammatory molecules. Discover more about the LPS model here: https://hubs.la/Q02bDfPj0

Watch our On-Demand webinar - focusing on Hevylite® assays in the patient pathway. Listen to Dr Lauren Campbell and Dr Ross Sadler, from the Oxford University Hospitals NHS Foundation Trust, as they describe their experience using Hevylite assays in a clinical immunology laboratory. You can watch it here: https://hubs.li/Q028Y_Yf0

Webinar Part 3 | Advantages of Fluorescence in Cell Counting What should be taken into consideration when choosing a cell counting method? In this video, Dan explains why choosing the correct method for your sample type is important for ensuring measurement accuracy. Watch the full webinar now: https://buff.ly/3DaBepP #LifeScience #Laboratory #Microbiology #CellBiology #CellCulture #LaboratoryEquipment #Immunology #CancerResearch #FlowCytometry #Webinar

Access our on-demand webinar to learn about how scientists are leveraging single-cell epigenomics assays like ATAC-seq, whole transcriptome assays and image-based spectral sorting to drive deep immunology discovery. Watch now: https://bit.ly/3LfsiU6 #epigenomics #transcriptomics #spectralflowcytometry #ATACseq #singlecellmultiomics #BDRhapsody #BDBiosciences