Crinetics Pharmaceuticals’ Post

"Sarcopenia: A dive into metabolism to promote a multimodal, preventive, and regenerative approach." The publication provides insights into the role of preventive and regenerative medicine in addressing sarcopenia and gives a comprehensive overview of the metabolic changes associated with aging and sarcopenia. https://lnkd.in/dZFTUcqi

#HighlyCitedPapers   📝 Disruption of the Ubiquitin-Proteasome System and Elevated Endoplasmic Reticulum Stress in Epilepsy — Poliquin and Kang.   In this paper, the authors present recent work on the pathomechanisms of abnormal protein folding and degradation in #epilepsy, as well as treatment developments targeting this area.   Full text is available 👇 https://lnkd.in/dX8pN82J   #medicine #health #research #science

Retinitis pigmentosa (RP), defined more properly as cone–rod dystrophy, is a paradigm of inherited diffuse retinal dystrophies, one of the rare diseases with the highest prevalence in the worldwide population and one of the main causes of low vision in the pediatric and elderly age groups. In this paper, the authors focus on the pathomolecular mechanisms underlying RP better to understand the prospects of its treatment using innovative approaches. 📝 The New Era of Therapeutic Strategies for the Treatment of Retinitis Pigmentosa: A Narrative Review of Pathomolecular Mechanisms for the Development of Cell-Based Therapies — Becherucci, et al. Full text is available 👇 https://lnkd.in/dNHZceVz #medicine #health #research #science 

A recent study explored the intricate dynamics of Diabetic Osteoporosis using our DIGIMUS BMD Analysis Software. The investigation delved deep into the effects of chromium picolinate on bone health in diabetic rats, offering promising insights for future research and clinical applications. Here’s the link to the study: https://lnkd.in/gsWDQBgj Data Source: Hongxing Zheng, School of Biological Science and Engineering, Shaanxi University of Technology, China, et al. Chromium Picolinate Regulates Bone Metabolism and Prevents Bone Loss in Diabetic Rats. https://lnkd.in/g3TbHnmY #ScientificInnovation #MedicalTechnology #LabEquipment #ResearchTools #BiotechSolutions #HealthcareInnovation #DigitalPathology #ImagingTechnology #PrecisionMedicine #LifeSciences #MedTechAdvancement #LabScience #HealthTech #DiagnosticImaging #InnovativeSolutions #KUBTECScientific #KUBTECImaging #KUBTECLabSolutions #KUBTECPrecisionInstruments #NonDestructiveTesting #XrayImaging

#ParticularInterestPaper   📝 Expression Profile of CD157 Reveals Functional Heterogeneity of Capillaries in Human Dermal Skin — Michalak-Micka, et al.   In this paper, the authors studied the role of CD157 in leukocyte trafficking via the binding of ECM components.   Full text is available 👇 https://lnkd.in/dawRNXyV   #medicine #health #research #science

#HighlyCitedPapers   📝 A Novel 2-Hit Zebrafish Model to Study Early Pathogenesis of Non-Alcoholic Fatty Liver Disease — Kulkarni, et al.   In this paper, the authors aimed to present a novel 2-hit zebrafish model to replicate aspects of #NAFLD pathogenesis.   Full text is available 👇 https://lnkd.in/d7aqzugb   #medicine #health #research #science

GLOMERULONEPHRITIS (GN) - - Definition, types, cusses, pathophysiology, signs & symptom, medicine

#HighlyCitedPapers   📝 Role of CCR2-Positive Macrophages in Pathological Ventricular Remodelling — Veera Ganesh Yerra and Andrew Advani.   In this paper, the authors present a well-structured and comprehensive review on chemokine receptor C-C type 2 that has an implicated role in adverse remodeling as a specific subset of #macrophages.   Full text is available 👇 https://lnkd.in/dwhuAGTe   #medicine #health #research #science

A combination of genetics and medicine: our future Ever heard of personalised medicine or precision medicine? It is the future. Personalised medicine (or precision medicine) is a treatment or prevention approach that takes account of an individual’s genetics, environment and lifestyle. It is our aim to promote it. ✨ We can help you to start off with precision medicine. 💊 #mgrc #dtect #genes #precisionmedicine #personalised #personalisedmedicine #medicine #treatment #prevention #health

#OpenAccess Miano et al: What factors influence implementation of “race-free” creatinine & cystatin C-based kidney function equations? Society of Critical Care Medicine #DEI in Renal Clinical Practice Task Force @ASNKidney National Kidney Foundation Link: https://ow.ly/iAcX50RMotL #CritCareMed #renalICU Fig: Nonrenal determinants of creatinine & role of race