Curiox Biosystems’ Post

⏰ Set your alarm for 17:15 today, so you do not miss Davide Carta's presentation "Engineering outer Blood Retinal Barrier on a chip to model pathological events in eye and study the effect of modulator drugs" at EUROoCS. Founded by Bi/ond and Dompé, Davide's PhD research show the potential that this innovative OoC model has to push forward retinal disease research and development of therapeutic methods for it. #euroooc #organonchip #inchipit #biomedicalresearch #microfluidics #gobiond

Engineering extracellular vesicles as miRNA nano-shuttles: in this review article, Dawit Tesfaye at Colorado State University and collaborators explored the therapeutic potential of EV-coupled miRNAs, detailing the biogenesis, contents, and functions of EVs. They provided an in-depth discussion of current EV loading techniques and highlights recent advancements in miRNA-engineered EVs as a next-generation platform https://lnkd.in/eAsvFcBb Their study emphasised how these innovations are advancing benchtop studies and paving the way for potential clinical applications in nanomedicine. An article also authored by Nico G. Menjivar, Jaiden Oropallo, Samuel Gebremedhn, Ph.D., Luca A. Souza, Ahmed Gad and Christian Puttlitz #extracellularvesicles #exosomes #miRNA #bioengineering #translationalmedicine #Vesiculab

🚀 Paralab Bio SL is pleased to announce Oksana Reznichenko from Malvern Panalytical as an invited speaker at the Biophysics Meeting in Fundación Parque Científico de Madrid. This event is specially designed for researchers in the field of biophysics and will feature a series of expert talks on the most innovative techniques used in the biophysical characterization of macromolecules. Attendees will gain valuable insights into methods such as 𝐜𝐢𝐫𝐜𝐮𝐥𝐚𝐫 𝐝𝐢𝐜𝐡𝐫𝐨𝐢𝐬𝐦 (𝐂𝐃), 𝐧𝐚𝐧𝐨 𝐃𝐢𝐟𝐟𝐞𝐫𝐞𝐧𝐭𝐢𝐚𝐥 𝐒𝐜𝐚𝐧𝐧𝐢𝐧𝐠 𝐅𝐥𝐮𝐨𝐫𝐢𝐦𝐞𝐭𝐫𝐲 (𝐧𝐃𝐒𝐅) and 𝐒𝐮𝐫𝐟𝐚𝐜𝐞 𝐏𝐥𝐚𝐬𝐦𝐨𝐧 𝐑𝐞𝐬𝐨𝐧𝐚𝐧𝐜𝐞 (𝐒𝐏𝐑), 𝐆𝐫𝐚𝐭𝐢𝐧𝐠-𝐂𝐨𝐮𝐩𝐥𝐞𝐝 𝐈𝐧𝐭𝐞𝐫𝐟𝐞𝐫𝐨𝐦𝐞𝐭𝐫𝐲 (𝐆𝐂𝐈). 🔗 𝐌𝐨𝐫𝐞 𝐢𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐚𝐛𝐨𝐮𝐭 𝐭𝐡𝐞 𝐞𝐯𝐞𝐧𝐭: https://lnkd.in/dAStD39a 📝 𝐒𝐢𝐠𝐧 𝐮𝐩 𝐝𝐢𝐫𝐞𝐜𝐭𝐥𝐲: https://lnkd.in/d4ju2Kwd Join us for an enriching experience designed to deepen your understanding of the molecular complexities of biological systems! 🌟 #biopharma #biophysicalcharacterization #creoptix #wavesystem

Missed our live webinar? Catch it on-demand now! ❔ Did you miss the recent webinar on 𝘖𝘳𝘨𝘢𝘯𝘰𝘪𝘥 𝘔𝘦𝘦𝘵𝘴 𝘔𝘪𝘤𝘳𝘰𝘦𝘭𝘦𝘤𝘵𝘳𝘰𝘥𝘦 𝘈𝘳𝘳𝘢𝘺 (𝘔𝘌𝘈) with Dr. Sven Schönecker (Global Product Manager, Multielectrode Array) as well as Sara Mirsadeghi (MSc and PhD student at The University of Texas at San Antonio)? No worries! 🎥 Register and watch the webinar on-demand: https://lnkd.in/ea-ytAgP 🧠 Don't miss out on the opportunity to explore the latest insights and advancements on how 3D Mesh MEA technology will shape drug discovery and development in the future. #webinar #researchscience #MeshMEA #organoids #organoidresearch

Exciting Research Alert! Join us at #RSCPoster Conference 2024 as we unveil our groundbreaking work on "Why long-scale MD simulation? Insights from the discovery of novel B, C-ring truncated deguelin derivatives for cancer treatment"! Curious about the journey to designing deguelin derivatives with reduced side effects? We've delved deep into the realm of cyclin D1 and cyclin E inhibitors, exploring a series of B, C-ring truncated derivatives. Our research applies cutting-edge drug-like filters such as REOS and PAINs series, followed by rigorous molecular docking using Schrodinger software. But wait, there's more! We've embarked on a journey of long-scale MD simulation to unravel the binding stability of deguelin and its derivatives. Our dynamic study unveils fascinating insights – while all compounds exhibited stability during 100ns of MD, a surprising twist was observed in the CyclinD1-Deguelin complex. At 120ns, Deguelin shifted its position, binding to another cavity of the receptor. This highlights the necessity of long-scale MD simulation to capture real structural and conformational changes. Don't miss out on this captivating exploration at #RSCChemBio! We're eager to share our findings and discuss your burning questions. Read related article from this study: https://lnkd.in/gK5v5dgn Google Scholar: https://lnkd.in/grv4xZ7W #Research #Science #CancerTreatment #MDsimulation

Did you hear? Earlier this week we launched Depixus MAGNA One! As part of our launch, we’re thrilled to announce an exclusive webinar in partnership with the Biophysical Society! 📅 Date: October 9, 2024 ⏰ Time: 12:00 PM - 1:00 PM EST 🎤 Hosted by: Gordon Hamilton, CEO of Depixus Depixus MAGNA One is the world’s first large-scale magnetic force spectroscopy platform. It allows you to see biology as it really happens—offering unprecedented real-time insights into thousands of biomolecular interactions simultaneously. Our game-changing laboratory instrument can analyze individual and multi-way interactions between DNA, RNA, proteins and small molecules, including challenging targets such as RNA and protein-protein interactions. Whether you're exploring fundamental biological mechanisms or developing novel therapeutics, don’t miss this chance to explore how Depixus MAGNA One can transform your research. 👉 Register for the webinar here: https://lnkd.in/gzq-v2kx 👈 #Biophysics #DrugDiscovery #Interactomics #DrugDevelopment #Webinar 

How to improve light sources for biomedical and healthcare applications : the challenge that the HILIGHT project has to overcome ! HILIGHT means ‘Highly Integrated Versatile Laser Source enabling two-photon excitation in digital diagnostics and biomedical research’. This project started at the end of 2023, proposes a miniaturised and versatile optical pulse burst source together with innovative sensing technology. This will permit to overcome limitations in SoA instrumentation that often confine the use of two-photon microscopy and time-resolved detection to the specialist laboratory. Two key applications are particularly targeted : instantaneous digital histopathology and cancer research and diagnostics. Other partners : Centre Suisse d’Electronique et de Microtechnique (CSEM), VivaScope GmbH - US Market, Fondazione Bruno Kessler - FBK, Brunel University London Website : hilighthorizon.eu #twophotonexcitation #fluorescencelifetimeimagingmicroscopy

During the smartHEALTH European Digital Innovation Hub Study Visit , Giannis Zacharakis from the LBMI at FORTH-IESL presented significant advancements in biomedical imaging technologies and services offered to the scientific community. His presentation highlighted the lab's work on innovative imaging systems designed to enhance the understanding of complex biological systems, with applications ranging from subcellular analysis to whole-organism imaging. Some key highlights included:  🔹 Next generation hybrid molecular imaging systems for multiscale, multiparametric bioimaging   🔹 Artificial bioengineered platforms for oncology and drug screening   🔹 Advanced algorithms for high performance image processing  🔹 Bioimaging experiemental protocols and standardization procedures  🔹 Miniaturized devices and accurate biosensors for health applications. An inspiring glimpse into the future of bioimaging and biosensing!

In today's #JournalClub paper, scientists at the UMR 7242 "Biotechnology and cell signaling"- a joint research unit supported by the CNRS and the University of Strasbourg used ATCC hTERT-HME1 & HCC1954 cells to explore the mechanisms underpinning #DNAMethylation in #CancerCells 🧬 Read the study at BMC: https://okt.to/pS12WX

I’m thrilled to share the preprint of our latest work, “Martini 3: Building Blocks for Lipid Nanoparticle (LNP) Design”, now available on #ChemRxiv! Read the full preprint here: https://lnkd.in/gvda2zFz #LipidNanoparticles (#LNPs) are powerful tools for nucleic acid (#mRNA) delivery, but optimizing them for specific targets and cargos remains a challenge. In this work, we’ve significantly expanded the #Martini3 #CoarseGrained force field to cover key LNP components, including over 100 ionizable lipid models and sterols, allowing us to study LNPs at coarse-grained resolution with unprecedented detail. Some additional highlights: - Detailed protocols for constructing whole LNPs, enabling us to examine their structure under different pH conditions and compare them with self-assembly models. - Testing the fusion efficacy of LNPs with target membranes, offering quantitative predictions for fusion behavior and efficiency under varying conditions. - Insights into membrane interactions and pH-dependent phase behavior of LNPs, helping optimize their ability to escape endosomes and release their cargo effectively. This paper is the result of a collaborative effort involving many people, including Lisbeth Thorup Ravnkilde, Mariana Valério, Markéta Paloncýová, Luís Borges Araújo, Fabian Grünewald, Roberto Carlos Pestana Nobles, Michal Otyepka, Siewert Marrink, Sangwook Wu, and many others. A big thank you to everyone who contributed to bringing this work to life. From my side, special thanks for the support of LBMC (Laboratory of Biology and Modeling of the Cell), #CBPsmn (Centre Blaise Pascal de Simulation et de Modélisation Numérique), #ENSdeLyon (École normale supérieure de Lyon), CNRS, CNRS Délégation Rhône Auvergne and PharmCADD. #Martini3 #LipidNanoparticles #LNPDesign #MolecularDynamics #DrugDelivery #mRNA #Vaccines.