Bi/ond

𝗔𝗱𝘃𝗮𝗻𝗰𝗲𝗱 𝗺𝗮𝘁𝘂𝗿𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗵𝘂𝗺𝗮𝗻 𝗰𝗮𝗿𝗱𝗶𝗮𝗰 𝘁𝗶𝘀𝘀𝘂𝗲 𝗴𝗿𝗼𝘄𝗻 𝗳𝗿𝗼𝗺 𝗽𝗹𝘂𝗿𝗶𝗽𝗼𝘁𝗲𝗻𝘁 𝘀𝘁𝗲𝗺 𝗰𝗲𝗹𝗹𝘀 Understanding and replicating the maturation process of cardiac tissues is crucial for advancing #regenerative medicine. The study by Kacey Ronaldson-Bouchard et al., demonstrates how early-stage iPSC-derived cardiomyocytes can be 𝗺𝗮𝘁𝘂𝗿𝗲𝗱 𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝗰𝗼𝗻𝘀𝗶𝘀𝘁𝗲𝗻𝘁 𝗽𝗵𝘆𝘀𝗶𝗰𝗮𝗹 𝗰𝗼𝗻𝗱𝗶𝘁𝗶𝗼𝗻𝗶𝗻𝗴 𝗮𝗻𝗱 𝗲𝗹𝗲𝗰𝘁𝗿𝗶𝗰𝗮𝗹 𝘀𝘁𝗶𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻. This is a novel approach to developing human cardiac tissues that exhibit adult-like heart #muscle characteristics. By subjecting these #tissues to increasing physical conditioning, the team achieved a level of maturation previously unattainable. This breakthrough has profound implications for studying heart diseases, drug testing, and potential therapeutic applications. The research was particularly interesting for Bi/ond to find about, as our muscle platform including pillars and electrical stimulation, aligns perfectly with the methodologies discussed in this paper. For us it signifies the 𝗽𝗼𝘁𝗲𝗻𝘁𝗶𝗮𝗹 𝘁𝗵𝗮𝘁 𝗼𝘂𝗿 𝗽𝗹𝗮𝘁𝗳𝗼𝗿𝗺 𝗰𝗮𝗻 𝗵𝗮𝘃𝗲 𝘁𝗼 𝗿𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻𝗶𝘇𝗲 𝗰𝗮𝗿𝗱𝗶𝗮𝗰 𝘁𝗶𝘀𝘀𝘂𝗲 𝗲𝗻𝗴𝗶𝗻𝗲𝗲𝗿𝗶𝗻𝗴 𝗮𝗻𝗱 𝗿𝗲𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝘃𝗲 𝗺𝗲𝗱𝗶𝗰𝗶𝗻𝗲. 📖 Read the full paper here: https://lnkd.in/dkHx_x7J #CardiacResearch #StemCells #RegenerativeMedicine #Bioengineering #gobiond

Have you tried Organ on Chip already? #ooc #gobiond #organonchip #research #animalfreeresearch

Do you spot some unknown faces in the picture below?? 👀 Raffaella Quarta and Giulia Gentili have been collaborating with our team since June developing models for skeletal muscle disease. Raffaella comes from Università degli Studi di Bari and she joins our team for the second time. Right now, she is focused on developing a 𝗻𝗲𝘄 𝟯𝗗 𝗺𝗼𝗱𝗲𝗹 𝗳𝗼𝗿 𝗗𝘂𝗰𝗵𝗲𝗻𝗻𝗲 𝗠𝘂𝘀𝗰𝘂𝗹𝗮𝗿 𝗗𝘆𝘀𝘁𝗿𝗼𝗽𝗵𝘆, as her research group is interested in studying how different DMD mutations affect muscle physiology. Giulia, on the other hand, comes from Università degli Studi di Perugia, where she collaborates with Prof. Guglielmo Sorci on the Cellular and Molecular Biology Myolab. Her research at Bi/ond focuses on the role of the 𝗥𝗔𝗚𝗘 𝗿𝗲𝗰𝗲𝗽𝘁𝗼𝗿 𝗶𝗻 𝗰𝗮𝗻𝗰𝗲𝗿-𝗶𝗻𝗱𝘂𝗰𝗲𝗱 𝗰𝗮𝗰𝗵𝗲𝘅𝗶𝗮 (you can read more about their objectives here: https://lnkd.in/e5XEsban Rafaella will continue working alongside the Bi/ond team until November, but we will be saying goodbye to Giulia in a few days. We want to wish her 𝗮𝗹𝗹 𝘁𝗵𝗲 𝗯𝗲𝘀𝘁 𝗳𝗼𝗿 𝘁𝗵𝗲 𝗲𝗻𝗱 𝗼𝗳 𝗵𝗲𝗿 𝗣𝗵𝗗 𝗮𝗻𝗱 𝗰𝗮𝗿𝗲𝗲𝗿 𝗳𝗼𝗿𝘄𝗮𝗿𝗱! #dmd #cancer #musculardystrophy #muscle #gobiond #collaboration

You may remember that we announced earlier on about our participation in the MAGIC Horizon project (Next-generation Models And Genetic therapIes for rare neuromusCular diseases) (*see below) Today, we wanted to give an quick update on it, as we continue to work towards accelerating the development of gene therapies and genome editing strategies for muscular dystrophies. Our participation in the MAGIC project is centered on 𝘁𝗵𝗿𝗲𝗲 𝗼𝗳 𝘁𝗵𝗲 𝘁𝗲𝗻 𝘄𝗼𝗿𝗸 𝗽𝗮𝗰𝗸𝗮𝗴𝗲𝘀 (see graphic under this text). We are working on multiple initiatives, including bioengineering advanced human quasi-vivo models of neuromuscular diseases, testing vectors and gene editing strategies in these models, and optimizing our devices for large-scale fabrication. Currently, the team at Bi/ond is keeping very busy with the development of 𝗗𝗠𝗗 (𝗗𝘂𝗰𝗵𝗲𝗻𝗻𝗲 𝗠𝘂𝘀𝗰𝘂𝗹𝗮𝗿 𝗗𝘆𝘀𝘁𝗿𝗼𝗽𝗵𝘆) 𝗺𝗼𝗱𝗲𝗹𝘀 𝗶𝗻 𝗼𝘂𝗿 𝗢𝗿𝗴𝗮𝗻-𝗼𝗻-𝗖𝗵𝗶𝗽, 𝘁𝗵𝗲 𝗠𝗨𝗦𝗯𝗶𝘁™, 𝗮𝗻𝗱 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗶𝗻𝗴 𝗻𝗲𝘄 𝗮𝘀𝘀𝗮𝘆𝘀. We expect that these advanced humanized muscle models, combined with the rest of the project team' results and gene theraphy approaches, will ultimately 𝗶𝗺𝗽𝗿𝗼𝘃𝗲 𝘁𝗵𝗲 𝗹𝗶𝘃𝗲𝘀 𝗼𝗳 𝗶𝗻𝗱𝗶𝘃𝗶𝗱𝘂𝗮𝗹𝘀 𝗮𝗳𝗳𝗲𝗰𝘁𝗲𝗱 𝗯𝘆 𝘁𝗵𝗲𝘀𝗲 𝗱𝗲𝗯𝗶𝗹𝗶𝘁𝗮𝘁𝗶𝗻𝗴 𝗱𝗶𝘀𝗲𝗮𝘀𝗲𝘀. #gobiond #dmd #magic #musculardystrophy #ooc *In case you do not remember, here is the link to the press release : https://lnkd.in/eTxxEjzX

It is that time of the year... summer! Everyone is looking forward to some time to unwind and leave the routine behind. What are you doing this summer? Are you climbing mountains or taking some time to wonder an unknown city? Wherever you go, the team at Bi/ond wants to wish you a pleasant time recharging batteries for the next chapter! While the summer is here, we are not fully disconnecting - some team members already enjoyed their time off and some are slowly going now - but we will for sure be busy, with lots of projects in the horizon: customer trainings, lab experiments, new collaborations, and continuous product ideas to develop. Enjoy! #gobiond #summervacay #beachormountain #enjoythesummer

You still can participate in our latest poll about potential clinical uses for our functional muscle model: https://lnkd.in/eneQz5Bv Inquire directly if you would like to know more about what we are already doing in the area of #duchenne or 𝗱𝗼𝘄𝗻𝗹𝗼𝗮𝗱 𝗼𝘂𝗿 𝗹𝗮𝘁𝗲𝘀𝘁 𝗽𝗼𝘀𝘁𝗲𝗿 𝗻𝗼𝘄! 𝗵𝘁𝘁𝗽𝘀://𝗿𝗲𝘀𝗼𝘂𝗿𝗰𝗲𝘀.𝗴𝗼𝗯𝗶𝗼𝗻𝗱.𝗰𝗼𝗺/𝗱𝗼𝘄𝗻𝗹𝗼𝗮𝗱-𝗽𝗼𝘀𝘁𝗲𝗿-𝗱𝗺𝗱 #dmd #3dmodels #skeletalmuscle #muscleresearch #cardiacmuscle #poll #download

(𝗙𝗲𝗺𝗮𝗹𝗲) 𝘀𝘁𝗿𝗲𝘀𝘀 𝘂𝗿𝗶𝗻𝗮𝗿𝘆 𝗶𝗻𝗰𝗼𝗻𝘁𝗶𝗻𝗲𝗻𝗰𝗲 is quite a taboo subject. This is probably why you have no idea that 𝘁𝗵𝗶𝘀 𝗮𝗳𝗳𝗲𝗰𝘁𝘀 𝗲𝘃𝗲𝗿𝘆 𝟰𝘁𝗵 𝘄𝗼𝗺𝗮𝗻 𝗮𝗳𝘁𝗲𝗿 𝗰𝗵𝗶𝗹𝗱𝗯𝗶𝗿𝘁𝗵. Deana Mohr-Haralampieva and her talented team at MUVON Therapeutics are developing a therapeutic platform for the regeneration of #skeletalmuscle tissue with initial focus in the treatment of stress urinary incontinence. They aim to establish #personalized, #regenerative treatments for women with this affection, supporting them respectfully throughout their journey to a healthy life. Be prepared to be inspired by this 𝗮𝗹𝗹 𝘁𝗲𝗿𝗿𝗮𝗶𝗻 𝗼𝗳 𝗮 𝘄𝗼𝗺𝗮𝗻: - Passionate about 𝗶𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝗼𝗻 and out of the box thinking - 𝗡𝗮𝘁𝘂𝗿𝗲 lover - 𝗠𝗼𝘁𝗵𝗲𝗿 of two toddlers - 𝗣𝗵𝗗 𝗶𝗻 𝗥𝗮𝗱𝗶𝗼𝗽𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹 𝗦𝗰𝗶𝗲𝗻𝗰𝗲𝘀 at ETH Zurich and CAS Clinical Trial Management - Secured a 𝗛𝗼𝗿𝗶𝘇𝗼𝗻𝟮𝟬𝟮𝟬 𝗚𝗿𝗮𝗻𝘁 (2016) to translate the results of her PhD Thesis into the MUS.I.C project for muscle tissue engineering - 𝗖𝗘𝗢 𝗮𝗻𝗱 𝗰𝗼-𝗳𝗼𝘂𝗻𝗱𝗲𝗿  of MUVON Therapeutics - 𝗧𝗲𝗮𝗺 𝗹𝗲𝗮𝗱𝗲𝗿 𝗼𝗳 𝘁𝗼𝗽 𝘁𝗮𝗹𝗲𝗻𝘁 previously working at companies like Novartis, Roche, Merck/ MSD, Pfizer and University of Zurich and ETHZ. - Awarded one of the 𝟭𝟬 𝗯𝗲𝘀𝘁 𝗠𝗲𝗱𝘁𝗲𝗰𝗵 𝗦𝘁𝗮𝗿𝘁 𝗨𝗽𝘀 by Venture Lab, and selected to represent the Swiss National Startup Team in Boston, USA (2021) - Awarded one of the 𝗧𝗼𝗽 𝟯𝟬 𝗥𝗶𝘀𝗶𝗻𝗴 𝗟𝗲𝗮𝗱𝗲𝗿𝘀  Across The Biopharma, Medtech and Health Technology Sectors by InVivo (2022) Read below our interview to Deana and be sure to follow MUVON Therapeutics AG as they are bound to deliver great results for millions of women around the world (and many more future applications). #gobiond #CwC #muscleregeneration #muscletissue #tissueengineering #incontinence #coffeewiththeCEO #deanamohr #muvon #regaincontrol

Our team of researchers at Bi/ond successfully created 𝟯𝗗 𝘀𝗸𝗲𝗹𝗲𝘁𝗮𝗹 𝗺𝘂𝘀𝗰𝗹𝗲 𝗺𝗶𝗰𝗿𝗼𝘁𝗶𝘀𝘀𝘂𝗲𝘀 𝘄𝗵𝗶𝗰𝗵 𝗲𝘅𝗵𝗶𝗯𝗶𝘁𝗲𝗱 𝗿𝗼𝗯𝘂𝘀𝘁 𝘁𝘄𝗶𝘁𝗰𝗵 𝗮𝗻𝗱 𝘁𝗲𝘁𝗮𝗻𝘂𝘀 𝗰𝗼𝗻𝘁𝗿𝗮𝗰𝘁𝗶𝗼𝗻 𝗽𝗿𝗼𝗳𝗶𝗹𝗲𝘀 𝘁𝗵𝗮𝘁 𝘀𝘁𝗿𝗲𝗻𝗴𝘁𝗵𝗲𝗻𝗲𝗱 𝗼𝘃𝗲𝗿 𝘁𝗶𝗺𝗲. The microtissues were obtained within our MUSbit™ organ-on-chip platform and using bit.bio’s ioSkeletal Myocytes. bit.bio presented this groundbreaking research at the #ISSCR 2024 event in Hamburg in this poster, 𝘀𝗵𝗼𝘄𝗰𝗮𝘀𝗶𝗻𝗴 𝗵𝗼𝘄 𝗶𝗼𝗦𝗸𝗲𝗹𝗲𝘁𝗮𝗹 𝗠𝘆𝗼𝗰𝘆𝘁𝗲𝘀 𝗰𝗮𝗻 𝗿𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻𝗶𝘇𝗲 𝗼𝘂𝗿 𝘂𝗻𝗱𝗲𝗿𝘀𝘁𝗮𝗻𝗱𝗶𝗻𝗴 𝗼𝗳 𝗺𝘂𝘀𝗰𝗹𝗲 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗱𝗶𝘀𝗲𝗮𝘀𝗲 𝗺𝗼𝗱𝗲𝗹𝗶𝗻𝗴. Download the poster to: ✅ Learn more about how iPSC-derived cells were incorporated in the Bi/ond #OoC culture system ✅ Discover what types of phenotypic as well as functional readouts can be made using the MUSbit™ chip ✅ See an example of how your disease model research can be implemented in an advanced 3D culture platform 🔗 Download the Poster Here: https://lnkd.in/eW-fAJmi #dmd #skeletalmuscle #3dModel #diseasemodeling #duchenne

As you probably know we are involved in research studies about #Duchenne Muscular Dystrophy (#DMD) using our organ on chip technology. We have successfully created #3Dmodels that mimic muscle status and reactions to drugs and stimulation. In what other clinical setting would you use our functional muscle (or which one are you already busy with)? Please add in the comments if your answer is not available to vote on - unfortunately, there are only 4 options possible to poll on. And if you are interested in what we have done for DMD, please check here https://lnkd.in/eqBVWJuq or get in contact with our team: https://lnkd.in/g3pKFHm

Bi/ond - together with the Dompé foundation - was proud to support Davide Carta’s research on the retinal vascularization on-chip model and his participation in EUROoCs24. The event allowed us to share our progress and gather valuable feedback and advice for further refining the model. We look forward to more opportunities like this where we directly, or through our collaborators, can showcase the advancements of the model. If you have any questions about Davide's research, please reach out to him or to us directly : https://lnkd.in/g3pKFHm. We will be happy to coordinate the discussion.