#citation Antibodies fight pathogens, generated through V(D)J rearrangement with low antigen affinity. Somatic hypermutation (SHM) enhances affinity, but the bias in concentrated hypermutations in CDRs remains a mystery for decades. Researchers revealed the molecular mechanism of high-frequency mutations induced by CDR regions through highly flexible features. This research was published in CELL, laying the foundation for optimizing antibody discovery and designing a new generation of humanized animal models. Congratulations to all contributors! The Fei-Long Meng team and the Leng-Siew Yeap Team! Read this article: https://lnkd.in/gpu_ZMYQ Cyagen is proud to be part of this amazing research with our animal model service (the IgVH-FR3TAC passenger allele mouse model). Learn more about Cyagen's animal models: https://lnkd.in/gZYvaDWV #CELL #citation #antibody #biotech #biotechnology #biotechnologyindustry #DNA #antigen #science #researchanddevelopment #research
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🚀Exciting News in Antibody Discovery! We're thrilled to announce the groundbreaking collaboration between Cyagen and Biointron, bringing a new era of innovation to fully human antibody discovery. The Cyagen HUGO-Ab™ & Biointron AbDrop™ platform, designed for high-throughput and fully humanized antibody development, sets a new standard in the field. Key Benefits: ✅ Faster Results: Go from target to fully human antibody in just 3 months. ✅ Enhanced Accuracy & Diversity: Access a diverse pool of high-quality antibody sequences. ✅ Cost-Effective: Significant reduction in development costs and timelines. ✅ Simplified Process: Streamlined IP and patent licensing. Our unique combination of HUGO-Ab™ fully humanized mice and AbDrop™ microdroplet technology enhances the discovery process, ensuring high-affinity, low-immunogenic antibodies that lead to safer and more effective therapeutics. With proven performance recognized by top pharmaceutical firms and academic institutions, we're paving the way for new antibody-based therapies. Discover more about how this next-generation platform can revolutionize your antibody drug development. Join us in transforming lives with cutting-edge innovation! Learn more here: https://lnkd.in/gVWyhhWc #antibodydiscovery #biotechnology #scienceandtechnology #biotech #biosciences #healthcare #drugdiscovery #preclinicalresearch
Cyagen HUGO-Ab™ & Biointron AbDrop™ High-Throughput Fully Human Antibody Discovery Platform
cyagen.com
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🌟 Don't miss our #Weekly Flash Sale! 🐭 Enjoy fantastic savings on mouse models this week (October 14). Discover amazing deals and discounts to advance your research. Hurry, it's a limited-time offer! 😎 Explore more options here: https://lnkd.in/gFSKCDqs #Savings #FlashSale #ResearchDeals #MouseModels #SummerScience #biotech #biosciences #biotechnology #scienceandtechnology #science #cyagen #HUGOGT
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🌟 Excitement is building for #ESGCT2024, just around the corner! Are you looking to discuss your gene and cell therapy projects or explore the latest innovations in the field? Join us for one-on-one meetings with our experts! Vice President - Reza Rezaei, DVM, PhD, MBA Sales Manager - Garland Li This is a fantastic opportunity to gain insights into our cutting-edge solutions and how we can support your research and development efforts. 🗓 Date: October 22-25 📍 Location: La Nuvola, Rome, Italy Don’t miss the chance to connect with us and discover what we have in store. We look forward to engaging conversations and collaboration opportunities! See you in Rome! ✨ #GeneTherapy #CellTherapy #Biotech #Innovation #Networking #Cyagen #biotechnology #scienceandcommunication
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#weeklynewsletter 🌟Harnessing Hep G2 Cells for Liver Cancer Research The Hep G2 cell line, derived from a 15-year-old male with hepatocellular carcinoma, is an indispensable tool in liver cancer research. These cells offer endless potential for studying drug metabolism, toxicity, and liver disease mechanisms. Key Applications: ✅ Liver Cancer Research: Understanding cancer development and therapy. ✅ Drug Metabolism Studies: Assessing drug safety and efficacy. ✅ Virology: Investigating hepatitis virus replication mechanisms. ✅ Gene Editing: Utilizing Smart-CRISPR™ for advanced functional studies. ✅ Cytotoxicity Testing: Evaluating liver toxicity of compounds. Best Practices for Culture: 🔹 Use high-quality, non-heat-inactivated FBS. 🔹 Monitor cell density and digestion closely. 🔹 Regularly check culture medium conditions. 🔹 With innovative tools like gene editing and validated xenograft models, Hep G2 cells pave the way for breakthroughs in liver cancer therapies. For expert support in Hep G2 applications and more, contact Cyagen today! #newsletter #cellline #cyagen #biotechnology #livercancer #cancerresearch
Hep G2 Cell Line: Liver Cancer Research Applications with Gene Editing & CDX Tumor Models
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🌟 Congratulations to Biointron for their groundbreaking speech! We're excited to collaborate with Biointron in ushering in a new era of innovation in fully human antibody discovery. The Cyagen HUGO-Ab™ and Biointron AbDrop™ platforms, designed for high-throughput and fully humanized antibody development, are setting a new standard in the field. Together, we’re paving the way for advancements that will benefit the scientific community and beyond!
𝐋𝐚𝐬𝐭 𝐰𝐞𝐞𝐤, 𝐰𝐞 𝐡𝐚𝐝 𝐭𝐡𝐞 𝐡𝐨𝐧𝐨𝐫 𝐭𝐨 𝐬𝐩𝐞𝐚𝐤 𝐚𝐭 𝐭𝐡𝐞 𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 𝐨𝐧 𝐓𝐚𝐫𝐠𝐞𝐭 𝟐𝟎𝟐𝟒 𝐬𝐮𝐦𝐦𝐢𝐭 𝐚𝐛𝐨𝐮𝐭 𝐭𝐡𝐞 𝐟𝐮𝐥𝐥𝐲 𝐡𝐮𝐦𝐚𝐧 𝐚𝐧𝐭𝐢𝐛𝐨𝐝𝐲 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 𝐭𝐞𝐜𝐡𝐧𝐨𝐥𝐨𝐠𝐲. 🎤✨ Our SVP, Dr. Lei Shi, presented “𝑆𝑖𝑚𝑝𝑙𝑖𝑓𝑖𝑒𝑑 𝑎𝑛𝑑 𝐻𝑢𝑚𝑎𝑛𝑖𝑧𝑒𝑑: 𝐸𝑚𝑝𝑜𝑤𝑒𝑟𝑖𝑛𝑔 𝐻𝑢𝑚𝑎𝑛𝑖𝑧𝑒𝑑 𝐴𝑛𝑡𝑖𝑏𝑜𝑑𝑦 𝐷𝑖𝑠𝑐𝑜𝑣𝑒𝑟𝑦 𝑤𝑖𝑡ℎ 𝐴𝑏𝐷𝑟𝑜𝑝™ 𝑆𝑜𝑙𝑢𝑡𝑖𝑜𝑛,” highlighting how the AbDrop™ solution, combined with Cyagen's transgenic mouse model, simplifies the process while delivering high-quality, fully human antibodies, accelerating the development of life-changing therapies. We’re excited about the possibilities this technology brings to researchers! If you’d like to dive deeper or request a copy of the slides, feel free to contact us at 📩 info@biointron.com. Let’s keep pushing the boundaries of antibody discovery together. 💡🔬 #Biointron #AntibodyDiscovery #AbDrop #HumanAntibodies #DOT2024
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🎥 Unlocking Corneal Dystrophy Treatments: Is B6-hTGFBI the Key? The revolutionary B6-hTGFBI model is transforming the landscape of corneal dystrophy treatments. This condition affects millions worldwide, characterized by abnormal substance accumulation in the cornea. The B6-hTGFBI model shows promise for groundbreaking treatments by targeting crucial proteins and bridging the gap between lab research and clinical trials. Genetic analysis confirms robust human TGFBI gene expression, setting new standards in ophthalmology and genetic research. Join the conversation and share your thoughts on these promising advancements (https://lnkd.in/g3yfUUwR). Together, let’s work towards a clearer vision for all! 👁️✨ #youtube #eyehealth #Research #Healthcare #ophthalmology #mousemodels #preclinicalresearch #biotech
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#citation 🛌 Sleep is a vital instinctive behavior essential for health, yet sleep disorders have become a global epidemic, affecting up to 40% of people in China. Insufficient sleep disrupts metabolic homeostasis, leading to conditions like diabetes and cognitive impairment. Recent research from West China Hospital of Sichuan University published a groundbreaking cover article in Cell Metabolism titled "𝘈𝘤𝘦𝘵𝘢𝘵𝘦 𝘌𝘯𝘢𝘣𝘭𝘦𝘴 𝘔𝘦𝘵𝘢𝘣𝘰𝘭𝘪𝘤 𝘍𝘪𝘵𝘯𝘦𝘴𝘴 𝘢𝘯𝘥 𝘊𝘰𝘨𝘯𝘪𝘵𝘪𝘷𝘦 𝘗𝘦𝘳𝘧𝘰𝘳𝘮𝘢𝘯𝘤𝘦 𝘋𝘶𝘳𝘪𝘯𝘨 𝘚𝘭𝘦𝘦𝘱 𝘋𝘪𝘴𝘳𝘶𝘱𝘵𝘪𝘰𝘯." This article was selected as both the cover and featured article for this issue. 📚 This study highlights the impact of fragmented sleep on glucose metabolism and cognitive function, revealing acetate's critical role in maintaining metabolic homeostasis. By activating pyruvate carboxylase, acetate promotes glycolysis and the TCA cycle in hypothalamic astrocytes, supporting glucose metabolism and cognitive health. Learn more here: https://lnkd.in/g_ZuKjHq Cyagen is proud to support this important research with our Acss1ᶠˡᵒˣ/ᶠˡᵒˣ mice. 🐭 Explore our services here: https://lnkd.in/gqxybj-x #SleepHealth #MetabolicHealth #CognitiveFunction #Research #CellMetabolism #biotechnology #biosciences #cyagen #scienceofreading
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🌟 Day 2 at #BioJapan2024! We're thrilled to connect with everyone. If you’re still attending, don’t miss the chance to meet our experts on-site! Stop by booth C-36 to chat with us and discover how we can support your research needs. See you there! 🚀 #BioJapan2024 #Networking #Biotech #Cyagen #mousemodels #biotechnology #biotech #preclinicalresearch #BioJapan #HUGOGT #HUGOAB
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Loving the vibes at #SfN2024! 😊 It’s the last day—if you’re still here, don’t miss the chance to visit us at booth 1008! We have more adorable mouse-themed swag waiting for you. Come grab some before they’re gone! 🐭 #sfn24 #neuroscience #biotechnology #sciencetalk #HUGOGT #HUGOUS #HUGOAB #cyagen #mousemodels #animalmodels
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🌍 Check out our conferences in October! 💠 Oct. 5-9 Chicago, IL- 𝐒𝐟𝐍 𝟐𝟎𝟐𝟒 💠 Oct 9-11 Yokohama, Japan - 𝐁𝐢𝐨 𝐉𝐚𝐩𝐚𝐧 𝟐𝟎𝟐𝟒 💠 Oct 17-18 Gyeongju, South Korea - 𝐊𝐨𝐫𝐞𝐚 𝐍𝐨𝐧-𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐓𝐫𝐢𝐚𝐥 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐀𝐬𝐬𝐨𝐜𝐢𝐚𝐭𝐢𝐨𝐧 𝟐𝟎𝟐𝟒 𝟒𝟔𝐭𝐡 𝐖𝐨𝐫𝐤𝐬𝐡𝐨𝐩 💠 Oct. 21-23 Seoul, South Korea - 𝟐𝟎𝟐𝟒 𝐅𝐚𝐥𝐥 𝐈𝐧𝐭𝐞𝐫𝐧𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐂𝐨𝐧𝐯𝐞𝐧𝐭𝐢𝐨𝐧 𝐨𝐟 𝐏𝐒𝐊 💠 Oct 24-27 Rome, Italy - 𝐄𝐒𝐆𝐂𝐓 𝟐𝟎𝟐𝟒 Stay tuned for more details about each event. We look forward to seeing you there! 😎 #Events #Networking #Innovation #Cyagen #GlobalOutreach #biotech #biotechnology #biosciences #lifescience #conference
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