DANISH BIO - DANSK BIOTEK’s Post

Back in the Bullpen, Graham Long talks to IBTV about how BioKresko can support young companies to identify their route to market and accelerate their solution to market through market research, product management and business development strategy.   🎥 Watch the full interview, below 👇 https://lnkd.in/g_NPRz83   #BIO24 #BIO2024 #RouteToMarketStrategy

Even we're intrigued to see how Mark Condina will weave Tim Tams into his lightning talk and poster presentation today about our Dataset Service, which is transforming data interrogation by enabling multiple dataset re-analyses and facilitating workflow integration. Join Mark to learn more about igniting collaborative Proteomics data analysis at scale!...and Tim Tams! Lightning talk: Mon 11th Mar 10am-11.30am, and Poster session: P09.01 1:30pm-3pm PDT #massgeek #TeamMassSpec #massspec #massspectrometry #proteomics #lifescience #biotech #biotechnology #Arnotts #TimTams #timtamslam

Check out the video record of our recent Coffee break with TRANSFAC devoted to identification of tissue-specific transcription factor target genes https://lnkd.in/e6-iMtN9 The list of questions addressed and their time codes: 01:42 If you have a list of genes that you are studying and these genes are expressed in a certain tissue, which transcription factors are regulating them? 02:39 Example of artificial tissue construction for heart muscle (GSE 261628) https://lnkd.in/eHGc6Y7W RNA-seq of cardiomyocytes with fibroblasts cells vs. cardiomyocytes with fibroblasts and with macrophages cells 04:55 Finding upregulated genes and analyzing their promoters 06:58 Promoter analysis of genes with a focus on their expression patterns 11:11 Logging in to the geneXplain platform 13:50 Upload of an Excel file with gene counts for identification of DEGs 16:57 Analysis of regulatory regions of selected genes using TRANSFAC (promoter analysis) 23:48 Observing the enriched motifs found in the promoters of the studied genes. Site enrichment and sequence enrichment. 26:37 Finding actual TFs corresponding to the found motifs by applying the gene expression filter (with a focus on heart muscle expression) 30:36 MATCH Suite gene set analysis - interface overview 31:40 – Different types of TFs and similarity of their binding motifs within the same family on the example of IRF factors. Difference in their expression levels in various tissues. 34:34 Constructing a tissue-specific gene set with MATCH Suite 38:42 Gene set analysis results overview in MATCH Suite 45:45 Heatmap visualization of motifs specific for a particular subset of GO terms 49:51 Can analysis of other organisms (not human) be performed using the TRANSFAC database? Analysis of model organisms in the geneXplain platform. 53:06 In the shown tables we saw that several matrices were linked to one factor. How can this be interpreted? Can there be two or more motifs linked to a specific factor? 58:58 Genome Enhancer and TRANSFAC database brief overview #bioinformatics #SystemsBiology #geneXplain #TRANSFAC #CoffeeBreakWithTRANSFAC #GeneRegulation #Transcription #TranscriptionRegulation #TranscriptionFactors #Genes #research #Biology #PromoterAnalysis #TFBS #TranscriptionFactor #DNA #BindingMotif #PWM #PositionalWeightMatrix #TranscriptionFactorBindingSite #freeseminar #QandA #seminar #webinar #freewebinar #Tissue #TissueSpecificity

Check out the video record of our recent Coffee break with TRANSFAC devoted to the release 2024.1 of geneXplain's products https://lnkd.in/eGZEC-3v Questions addressed and their time codes: 00:37 TRANSFAC release 2024.1 stats overview 02:15 HumanPSD + TRANSPATH release 2024.1 stats overview 04:48 Short tour to TRANSPATH: pathways, reactions, molecules, complexes 18:18 MATCH Suite for human, mouse, and rat genes analysis. Demo analysis on a Rat dataset of cardio fibroblasts (GSE238154 https://lnkd.in/estQMzz3) 23:07 Is there a preference to the type of entities when represented in a pathway? E.g. do you prefer evidence level entities to pathway or semantic level entities 25:44 Importing data from GSE238154 to the geneXplain platform (read counts); identification of DEGs with Limma and filters 29:29 Analysis of upregulated genes from GSE238154 with MATCH Suite. Applying different analysis launch parameters: narrowing down the profile to certain TFs and functional categories 40:43 TRANSPATH database content overview. PDL1 activation pathway. 52:52 Applying Genome Enhancer tool for the analysis of colorectal cancer dataset (PMID: 38520088 https://lnkd.in/e9_bv-pa). Pathway analysis, identification of master regulators, associated drug targets and treatments for potentially overcoming the resistance to PD-L1 therapy. 01:00:46 HOMER tool in the geneXplain platform. Overview of the analysis results. #bioinformatics #TRANSFAC #TranscriptionFactor #GeneRegulation #genes #DNA #SystemsBiology #TFBS #motifs #SiteSearch #PWM #promoter #enhancer #PathwayAnalysis #UpstreamAnalysis #pathways #pathway #REACTOME #MasterRegulator #GenomeEnhancer #geneXplain_platform #TRANSPATH #transcriptomics #HumanPSD #MATCHSuite #HOMER #Release

@Catailyst, Inc. Trending Topics: Sangamo Therapeutics, Inc. Therapeutics Announces Alignment With FDA on Accelerated Approval Pathway for ST-920 in #Fabry Disease With BLA Submission Expected in 2025 https://lnkd.in/d-HxtncX FDA confirms that estimated glomerular filtration rate (eGFR) slope data at one year across all Phase 1/2 patients can serve as primary basis for approval under Accelerated Approval pathway #Timeline Data supporting Accelerated Approval pathway available in first half of 2025 BLA submission expected in the second half of 2025. #Healthcare #FDA #Biotechnology #Fabry

Tomorrow marks the 4th of July, a day to celebrate America's independence and the innovative spirit that has fueled our nation. Here at BioHub Maryland, we're proud to carry that torch forward by fostering collaboration and accelerating talent in the life sciences industry. Celebrate with us by answering one of these questions in the comments below: • What scientific discovery are you most grateful for? • How do you see science shaping the future of America?

We are talking about traceability and the digital product passport at ProcessTeknik today! Come and listen if you are around!

The Fruit of Knowledge is a current project that coincidently has come ten years after contributing to the early online success of cannabis businesses after legalization in Colorado. I was working with the Weed Life Network and was part of an SEO team that came up with 'Dispensary' as the keyword search term that was recognized as code for recreational marijuana ~ LOL. As they say, we've come a long way, baby! At least with the emerging psychedelic industry, we can use actual names and correct terms to share information online. Hat tip to all of my connects from those early days of path-finding and trail-blazing. *In 2024, the global cannabis market is projected to reach nearly $40 billion in gross revenue. It's important to note that this figure includes both legal and illegal cannabis markets. The legal market is growing rapidly as more countries and states legalize cannabis for medical and recreational use.

Insights from the coAmplifi team! 💪 We asked our team member Deepa about what coAmplifi features she finds most helpful. Here's what she had to say: "Fishtank is a coAmplifi feature that I use every day. I use the Cohort View to get a better understanding of what my team is working on in real-time. I'm also able to toggle to the Select View to see how much time is spent on tasks and thereby determine if greater efficiencies can be found."

Hope to see you tomorrow! Scheer Partners Scientific Real Estate leverages our vertically-integrated life science platform supported by best-in-class data analytics and an incredible team. - Market and labor analytics - Economic incentive negotiations - Lab development feasibility and investment - Business model optimization and financial analysis - Ecosystem & strategic planning #2024BioInnovationConference #BioBlast #RealEstate #Investment