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How to fully untap the #anti_tumoral potential of #siRNA? Scientists have come up with a smart way to #deliver this drug modality to tumor cells by optimizing the divalent lipid-conjugated siRNAs for in situ binding to albumin. A preclinical proof of concept was achieved in a model of orthotopic triple negative breast cancer (TNBC) tumors, where the Lead molecule showed greater PK/PD properties than the parent molecule. https://lnkd.in/ehvxYd9u

Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy - Nature Communications

Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy - Nature Communications

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