Demos Bio Consulting’s Post

I am thrilled to announce that our paper is online. Title: Effectiveness of [67Cu]Cu-trastuzumab as a theranostic against HER2-positive breast cancer. Using the same bifunctional chelator/isotope for imaging and therapy " is exciting". This manuscript showed excellent SPECT images and how effective [67Cu]Cu-trastuzumab was in trastuzumab-sensitive and trastuzumab-resistant tumor xenografts. # copper67 # theranostic # radiopharmaceuticals # radiotherapy https://lnkd.in/gXJ6XMBH

"Ferroptosis plays an important role in response to radiotherapy and chemotherapy, however, the sensitivity of cancer cell to ferroptosis varies. Here, the authors show that ODC1-mediated polyamine synthesis induces ferroptosis and demonstrate the potential of targeting this axis by combining polyamine supplements with radiotherapy or chemotherapy in preclinical lung cancer models." "In this study, after the identification of the ferroptosis-promoting role of arginine using the metabolites library, the researchers confirmed that the arginine-ornithine-polyamine axis emerges as the dominant metabolic pathway of arginine." https://lnkd.in/e3B4rRGg

ICYMI: Data published in The International Journal of Radiation Oncology, Biology, Physics further validate the clinical utility of @Veracyte's #Decipher Prostate test to help guide treatment selection in people with intermediate-risk prostate cancer. The findings from the post hoc analysis of Phase III NRG Oncology/RTOG 0126 randomized clinical trial of intermediate-risk prostate cancer patients treated with definitive radiotherapy are the first to demonstrate the validity of a widely used prognostic biomarker in this setting. Read the publication here: https://lnkd.in/gvFk4aDc #ProstateCancer

Congratulations to the teams led by Prof. Beat W. Schafer for their recent research investigating the role of the AXL receptor tyrosine kinase in rhabdomyosarcoma (RMS), a pediatric cancer with a poor response to chemotherapy. The team found that targeting AXL with small molecule inhibitors, such as bemcentinib, enhanced the effectiveness of chemotherapy drugs like vincristine and cyclophosphamide, offering a promising strategy to improve treatment outcomes for RMS patients. In investigating the role of AXL in promoting migration in FP-RMS cells, researchers employed both genetic knockout and pharmacological inhibition methods. They conducted a wound-healing assay using an automated live-cell imaging system, Celloger® Mini. We appreciate Celloger® being part of the research. To read the full article: https://lnkd.in/g9XzabA2 More information about Celloger®: https://lnkd.in/d5zmFaat #livecellimaging #celloger #cellogermini #curiosis #AXL #RMS #woundhealing

FINALLY! https://lnkd.in/diJbCUcg Novel PET Tracer Enhances Lesion Detection in Medullary Thyroid Cancer, Offers Potential for Targeted Therapy #snmmi #PET #NUCLEARMEDICINE #MEDULLARY #THYROID #CANCER

Want to learn more about the relevance of detecting PSMA positivity in advanced prostate cancer patients from a simple blood test? Check out this great interview in Targeted Oncology with our collaborator Dr. Jacob Berchuck. https://bit.ly/4e7gBvE #ProstateCancer #Epigenomics #PrecisionMedicine #DrugDevelopment

Dear all I am pleased to share our article entitled "Synergistic chemo-photothermal therapy using gold nanorods supported on thiol-functionalized mesoporous silica for lung cancer treatment" in Scientific Reports (IF: 4.996).

🔬I am thrilled to announce the publication of our latest science paper, “Current Advances in Photodynamic Therapy (PDT) and the Future Potential of PDT-Combinatorial Cancer Therapies,” in MDPI. This paper offers a comprehensive review of Photodynamic Therapy (PDT), a revolutionary two-stage cancer treatment that combines light energy, oxygen, and innovative photosensitizers. We discuss the use of quantum dots as cutting-edge photosensitizers and energy donors. Additionally, we highlight the promising potential of combining PDT with radiotherapy and immunotherapy as future cancer treatments. Our study also emphasizes the significance of organoids as physiologically relevant models for PDT, opening new avenues for research and treatment methods in oncology. Read our full paper here: https://lnkd.in/gPWsyghJ #CancerResearch #PhotodynamicTherapy #Nanotechnology #QuantumDots #SciencePublication #PDT #MDPI #sevillaslab

Source: Omics : a journal of integrative biology This article examines the profiling of kinase activities in diffuse gastric cancer (DGC) for precision oncology. The study analyzes the phosphoproteome of DGC and identifies several kinases that are hyperphosphorylated or hypophosphorylated in DGC tissues. Additionally, potential therapeutic targets in DGC, such as heparin-binding growth factor, heat shock protein 90, and FTH1, are discussed. These findings contribute to our understanding of signaling alterations in DGC and may lead to the discovery of novel actionable targets in gastric cancer.

Ovarian cancer is one of the most common malignancies in women worldwide. Unlike breast cancer, ovarian cancer lacks early diagnostic markers and does not show noticeable symptoms until cancer metastases, leading to a low survival rate for ovarian cancer patients. Traditional cancer treatments include surgery, radiation therapy, chemotherapy and interventional therapy. However, the distribution of chemotherapeutic drugs in vivo is non-specific and often toxic to healthy cells, leading to unsatisfactory efficacy. Learn more: https://lnkd.in/dvWmtGUT. 📑 Program: https://lnkd.in/dCFnWm5E 🗓 Date: October 17-18, 2024 📍 Location: Corinthia Palace, Malta #ExtracellularVesicles #Microbiota #Mitochondria #EVs #exosomes #microvesicles #mitovesicles