Depixus’ Post

What do you think will be the highlights from the Next Generation Enabling Technologies session at #SLAS2024?

Little late to post. Thrilled to share that my first review paper from my ongoing Ph.D., Advancing in vivo reprogramming with synthetic biology, has been published this year in Current Opinion in Biotechnology! In this paper, we discuss how synthetic biology is pioneering new ways to reprogram cells in vivo using DNA- and RNA-based tools, offering potential breakthroughs in precision medicine and cell therapy. Feel free to give it a read and share it with colleagues who may be interested in this latest perspective! #SyntheticBiology #InVivoReprogramming #CellTherapy #PhDResearch #PrecisionMedicine #FutureOfHealthcare https://lnkd.in/gWGam7Y6

🎉 Celebrating 2 Years of “Live-seq: Temporal Transcriptomic Recording of Single Cells”🔬   Two years ago, #LiveSeq coupled with #FluidFM technology was published in Nature Magazine for the first time, enabling time-resolved transcriptome analysis while preserving cell viability. Since then, this approach has opened new avenues in temporal #transcriptomics, particularly in taking subcellular biopsies for single-cell profiling!   Key Points: 🌟 Accurate Cell Stratification: Distinguishes diverse cell types and states without significant perturbations. 🌟 Mapping Cell Trajectories: Enables sequential profiling of cell transcriptomes before and after stimuli. 🌟 Transcriptomic Recording: Monitors cells over time, revealing key determinants like Nfkbia expression and cell cycle state. 🌟 Temporal Analysis: Transforms scRNA-seq from an endpoint to a temporal analysis method.   Here is the Nature paper from 2022 👉 https://lnkd.in/evQ4QHyd Learn more from Orane Guillaume-Gentil, Ph.D., EPFL, one of the inventors of Live-Seq👉 https://lnkd.in/eH-xNQ4Q   We’re excited about the future of FluidFM and its impact on cutting-edge research! Here’s to pushing the boundaries of what’s possible in single-cell analysis! 🎉🎂✨🍰🥳   #FluidFM #scRNAseq #LiveSeq #SingleCellAnalysis #Transcriptomics #Biotechnology #ResearchInnovation #CellBiology #GeneExpression #BiomedicalResearch #InnovativeTech #Biotech #ScientificBreakthroughs #MolecularBiology #Anniversary Wanze Chen Pernille Yde Rainer Christoph Gabelein Bart Deplancke Julia Vorholt Tomaso Zambelli Magda Zachara, PhD Riccardo Dainese Amanda Klaeger Vincent Gardeaux Wouter Saelens

Dive into the DNA Nanotech Revolution! 🧬✨ Uncover the driving forces propelling genomics and proteomics research, advancements in material science, and the burgeoning interest from the medical industry. Explore the intricate world of DNA origami, programmable nanoparticles, and nanoelectronics circuits shaping the future of precision medicine. 🌐💉 Learn More: https://lnkd.in/dVFsai4q #coherentmarketinsights #nanotechnology #nanotech #techinnovation #geneticengineering #nanomaterials #biotech #innovationinscience #futuretechtrends #biotechnology #emergingtechnologies #molecularbiology #biomedical #techindustryinsights #globalinnovation #genomic #nanomedicine #globalresearch

The impact of Cryo-EM on structureomics is tremendous, and this review offers an informative overview. Structureomics aims to create a comprehensive 'structureome,' detailing molecular models for nearly every protein across various genomes ( https://lnkd.in/gtYzZDW8 ). While experimental validation and accounting for dynamic protein structures are necessary, the structureome provides a deeper understanding of cellular states beyond gene sequences or expression levels. This advancement is revolutionizing structural biology, allowing researchers to explore molecular intricacies with unparalleled precision. Read this article… it's freely accessible! Did you know... our cutting-edge Cryo-EM services, alongside our exceptional expertise, are the key factors behind our clients' continuous project successes? Revolutionize projects with Helix and Cryo-EM. Call us! (https://loom.ly/XFNYiNI) #cryoem #crystallization #crystallography #drugdiscovery #drugdesign #protein #proteins #dna #rna #antibody #antibodies #science #nature #research #bio #bionetwork #biotechnology #biotech #bioscience #biotechnologyindustry #biopharma #drugdesign #drugdevelopment #pharmaceuticals #pharma #drug #lifesciences #lifescience

🔬 **Breakthrough in DNA Repair: A Game Changer for Medicine and Biotechnology** Exciting news from the scientific community! Researchers at Western University have discovered DNA Damage Repair Protein C (DdrC) in the bacterium *Deinococcus radiodurans*, a groundbreaking protein capable of halting DNA damage and initiating repair processes. 🧬 Key Highlights: 1. **Autonomous Functionality**: DdrC can detect and stop DNA damage independently, positioning it as a potential candidate for cancer vaccines. 2. **Transferability**: When transferred into *E. coli*, the ddrC gene increased UV radiation resistance by 40x, showcasing potential cross-organism applications. 3. **Mechanism of Action**: DdrC scans DNA for damage, binds and immobilizes breaks, compacts DNA segments, and signals repair mechanisms. **Implications for the Industry**: - **Medical Advancements**: New pathways for cancer vaccines and therapies. - **Biotechnology**: Enhanced genetic engineering capabilities. - **Space Exploration**: Better protection against cosmic radiation. - **Agriculture**: Potential creation of climate-change-resistant crops. Are we at the cusp of a revolution in DNA repair technology? What are your thoughts on how DdrC could be leveraged across various industries? Comment below and let’s discuss the potential! 🚀 #Biotechnology #MedicalInnovation #DNARepair #GeneticEngineering #NewDiscoveries

"Advancements in structural biology: How cryo-EM is unveiling new protein structures. This powerful imaging technique provides unprecedented views of the molecular machines that drive life, aiding in the development of new therapeutics. #StructuralBiology #Research #PhDApplication"

**Exploring the Realm of Synthetic Bioacoustics: The Intersection of Sound and Biotechnology** Synthetic bioacoustics is a burgeoning field merging acoustic engineering with synthetic biology to create innovative biotechnological solutions. Researchers are leveraging sound waves to manipulate biological processes, such as enhancing gene expression or accelerating biochemical reactions. For example, ultrasonic frequencies can trigger specific cellular responses, potentially revolutionizing drug delivery systems and tissue engineering. This interdisciplinary approach not only paves the way for breakthroughs in medical treatments but also offers novel insights into bio-sound interactions, which may redefine our understanding of biological communication. #SyntheticBioacoustics #Bioengineering #AcousticScience

Explore groundbreaking insights from recent scientific research leveraging the ISS Alba V5 confocal laser microscopy system. Researchers have unveiled how the reprogramming factor KLF4 plays a pivotal role in chromatin organization through biomolecular condensation with DNA—a process crucial for inducing pluripotency in cells. This study, utilizing the precision of our ISS Alba V5 system, revealed that KLF4 forms liquid-like condensates with DNA, even in the absence of its intrinsically disordered region. Remarkably, this condensation is significantly enhanced by CpG methylation at specific DNA sites, such as the NANOG promoter, a key gene in maintaining pluripotency. Through advanced single-molecule Förster resonance energy transfer (smFRET) analysis, conducted with the Alba V5, the research team was able to monitor the interactions between KLF4’s DNA binding domain and the NANOG promoter. The smFRET data provided crucial insights into how KLF4-DNA interactions are modulated by CpG methylation, highlighting the intricate molecular dynamics that govern chromatin reorganization. This research underscores the vital role our ISS instrumentation plays in advancing the understanding of fundamental biological processes, offering scientists the tools they need to uncover the mechanisms behind cellular identity and reprogramming. Full Publication: https://lnkd.in/dMqmRPXx More about Alba V5: https://lnkd.in/ghZj3C_t #ChromatinOrganization #KLF4 #BiomolecularCondensation #Pluripotency #smFRET #ConfocalMicroscopy #CpGMethylation #Epigenetics #GenomicResearch #StemCellResearch #MolecularBiology #ISSInstruments #AlbaV5 #ScientificResearch #CellReprogramming

Carbon dots (CDs) are gaining interest in medicine and pharmacy due to their stability, water dispersibility, and photoluminescence. CDs are explored for optical imaging, gene delivery, and theranostics. This report examines how Low Voltage Electron Microscopy (LVEM), particularly the LVEM 5, advances carbon dot research. https://bit.ly/3Vx5BzA