Cytosurge’s Post

**Exploring the Realm of Synthetic Bioacoustics: The Intersection of Sound and Biotechnology** Synthetic bioacoustics is a burgeoning field merging acoustic engineering with synthetic biology to create innovative biotechnological solutions. Researchers are leveraging sound waves to manipulate biological processes, such as enhancing gene expression or accelerating biochemical reactions. For example, ultrasonic frequencies can trigger specific cellular responses, potentially revolutionizing drug delivery systems and tissue engineering. This interdisciplinary approach not only paves the way for breakthroughs in medical treatments but also offers novel insights into bio-sound interactions, which may redefine our understanding of biological communication. #SyntheticBioacoustics #Bioengineering #AcousticScience

With magnetic force spectroscopy (MFS), you can directly measure the forces at work as biomolecules interact. Sounds amazing! So why isn’t it used more often? The problem is that traditional MFS techniques like magnetic tweezers can only analyze interactions between single molecules one at a time. This makes it a very slow process, and impractical for the scale demanded of today’s research pipelines. Our groundbreaking technology overcomes the limitations of traditional MFS techniques, allowing you to directly measure thousands of dynamic molecular interactions simultaneously. With our MFS platform, you can explore interactions between DNA, RNA, proteins, small molecules and more, offering a powerful new tool to explore biology, uncover disease mechanisms, and accelerate the development of novel therapeutics. Swipe through our slides below to discover how you can harness the power of MFS at scale. #interactomics #drugdiscovery #drugdevelopment #biophysics

🔬 Meet our our Protein Sciences team who deliver top-tier structural and biophysical data, to fuel your research. From protein production to crystallisation, and with access to the Diamond Light Source, we can unlock structure-based discovery for your targets. We also offer a range of biophysical assays to enable you to decode molecular interactions and dynamics, empowering your scientific exploration. Our suite of Protein Science tools, and access to our in house expertise, can help guide rational design for innovative therapeutics. Shape the future of drug discovery with Arctoris. Want to learn more? Check the link in the comments to get in touch!💡 #StructuralBiology #Biophysics #ProteinScience #DrugDiscovery #Arctoris #Innovation #Biotech #Crystallography 🚀

https://lnkd.in/g_9_PwUJ 😍I love this, "The birth of mass photometry: from ludicrous idea to ground-breaking scientific technique." Mass photometry has quickly moved from "new tech" to an established staple in the bioanalytical space for a reason. >500 scientific publications featuring mass photometry >400 mass photometers placed globally ~200 Refeyn employees passionate about introducing this novel tech to the scientific community Curious? Demo an instrument and let's see what mass photometry can do for you! sara.wilson@refeyn.com #vectoranalysis #biomolecularanalytics #antibodycharacterization #proteinproteininteractions #membraneproteinanalytics #biophysics #massphotometry

10x Genomics platforms: Chromium Single Cell, Visium Spatial Transcriptomics and Xenium In Situ are more than the sum of their parts. They are a testament to human ingenuity and collaboration, reflecting the spirit and dedication of those who build them and those who use them to advance human health. Chromium, Visium and Xenium were conceived and developed with a deep understanding of the challenges they aim to solve, making them indispensable tools in the pursuit of scientific advancement. However, the message from this year's 10x Genomics Global Distributor Meeting is clear: without the vibrant community of innovators and users, these platforms would lack the soul and effectiveness that make them truly remarkable. Big shoutout to our friends at Labena Slovenia, GeneTiCA Group, Analityk Genetyka, Euroclone SpA, BONSAILAB SL, PharmiGene, Inc., among others. See you next year! #GDM #collaboration #distributor #Chromium #Visium #Xenium #singlecell #spatialbiology #research #innovation

We’re paving the way through our collaboration with CiberMed to enable a new Targeted Digital Cytometry method from bulk RNASeq data! If you are doing immune cell profiling but need a way to scale your sample numbers or address tissue dissociation bias, this method might be for you! #targetenrichment #digitalcellprofiling #cellprofiling #immunecellprofiling #deconvolution #rnaseq #cibermed

An astounding paper by Choi et al. (Link: https://lnkd.in/g_4W_Qfu) wherein rotating magnetic fields were used to modulate behaviors in mice that were (i) genetically modified via an adenoviral vector to express mechanosensitive ion channels in specific cell types and (ii) injected with a magnetic nanoparticle that binds to the mechanosensitive ion channels. By injecting the adenovirus and the nanoparticles into certain brain regions, different behaviors such as social novelty preference and maternal pup retrieval could be altered using the magnetic fields. For now, this technology remains a neuroscientific tool. Yet in the future, it could have numerous exciting biomedical applications and may even facilitate more powerful and precise brain-computer interfaces! #neurotech #nanotech #biotech #genetherapy #syntheticbiology #biomedicine

Scientists Just Created Chromosomes From Scratch—'Huge' In a milestone achievement, a whole chromosome has been created from scratch by scientists for the first time ever. The tRNA Neochromosome is a man-made chromosome of the common baker's yeast Saccharomyces cerevisiae. It may soon allow for the creation of synthetic and superior yeast cells, according to a collection of new papers in the scientific journals Cell and Cell Genomics. This discovery is the newest in an international project called Sc2.0, which has also synthesized all 16 of the yeast's chromosomes with an aim to combine them into a functional cell that might help make yeast faster, more resilient and more productive. The tRNA Neochromosome is special, as it is entirely synthetic, not made based on one of the original chromosomes of the yeast. There is nothing like it in nature. The fact that it can function by producing tRNAs like a natural genome does is pretty amazing. It is also designed to avoid 'head-on collisions' between RNA polymerase and DNA polymerase, which can lead to DNA breaks and other challenges for the cell. The researchers hope to soon complete the final Sc2.0 strain, containing all the synthetic yeast chromosomes and the tRNA Neochromosome, marking the first synthetic eukaryote ever created. #opportunities #strategy #programming #design #team #research #data #health #development #collaboration #projects #testing #immunotherapy #cancer #technology #biotechnology #healthcare #medicine #oncology #precisionmedicine #liquidbiopsy #rna #dna #venturecapital #startup #immunooncology #tcells #innovation #growth #tech #lifesciences #biopharma #oncodxrx

Last month, I had the privilege of participating in a series of events centered around #singlecell and #spatialtranscriptomics, hosted by 10x Genomics and Parse Biosciences. Witnessing firsthand the rapid evolution within the industry, particularly in single-cell omics, has been truly inspiring. The pace at which this field is advancing is remarkable, opening up new avenues for research and innovation. The continuous advancements in single-cell technologies are not only accelerating the pace of discovery but also reshaping the landscape of molecular biology. It's an exciting time to be part of this transformative journey, and I'm thrilled to see where the future takes us. #SingleCell #Transcriptomics #Multiomics #Innovation #Research #10xGenomics #ParseBiosciences

I'd like to share my latest research paper, co-authored with our incredible team, has been published in the Physics of Fluids journal. This work focuses on the design and optimization of micromixers, which are essential components in microfluidics, micro-electro-mechanical devices, and various bio-chemical assays. Our study introduces a controllable intelligent framework that combines machine learning and statistical modeling approaches to enhance the efficiency and homogeneity of mixtures in micromixers. Our research addresses the challenges of designing micromixers that provide high homogeneity and low pressure drop while maintaining controllability. We've made significant strides in this area, including the development of a novel micro-structure with L-shaped baffles and the application of advanced optimization methods like NSGA-II and DE. This work not only advances our understanding of micromixer design but also has practical implications for gene engineering, nanoparticle synthesis, and cell lysis assays. We've observed that our proposed design can significantly increase the mixing index and reduce the pressure drop, demonstrating the potential of our approach in real-world applications. I invite you to read our paper and share your thoughts on our findings. Your insights and feedback are invaluable to us. 🔗 https://lnkd.in/drBvku8P #Research #Microfluidics #Micromixers #PhysicsOfFluids #MachineLearning #Optimization