Ansys Digital Twin’s Post

As highlighted by QbD principles, scale down system are commonly used in pharmaceutical process development to study the effect of manufacturing Critical Process Parameters (CPPs) on drug product Critical Quality Attributes in laboratory scale. However, translating manufacturing CPPs in small scale is often a challenge and might lead to undesired results if done improperly. In this work, "The quest for down scale representativeness: how to exploit CFD to design a shear study for vaccines", we show how Computational Fluid Dynamics can be used to translate CPPs into equipment and scale independent Process Engineer Parameters (PEPs) to ensure multiscale representativeness. https://lnkd.in/dRHgGw97

🚀 New Publication Alert! I am pleased to share our latest research, "The impact of the stopper position and geometry on the freeze-drying cycle of pharmaceutical products", now published! This study investigates how stopper positioning and geometry influence mass transport resistance during the freeze-drying process, using Computational Fluid Dynamics (CFD). We analyzed conventional batch freeze-drying, continuous freeze-drying, and low-fill-volume drug products, highlighting the significant impact of stopper configurations on process variables, particularly for low-fill-volume formulations. Read the full article here: https://lnkd.in/dPQxd85T Authors: Lorenzo Stratta, Roberto Pisano #PharmaceuticalResearch #FreezeDrying #Innovation #CFD #ComsolMultiphysics #Pharma

Finding your perfect match can be challenging – especially for pharmaceuticals! Learn about an efficient method to detect drug-excipient incompatibility in this application note: https://lnkd.in/gXV6yhxi #Pharma #DrugDevelopment

Study of Hydrodynamic Stress in Cell Culture Bioreactors via Lattice-Boltzmann CFD Simulations Supported by Micro-Probe Shear Stress Method Mammalian cell cultivation in pharmaceutical industry can last up to units of weeks and requires proper transport of nutrients and oxygen for cell growth and production. Given the long time period, cells experience flow fields from all bioreactor’s zones, where the energy dissipation rate (ε) varies substantially. For the very first time, the micro-probe method is applied successfully not only to laboratory (3 L) and pilot scale (80 L and 200 L), but also to industrial production scale bioreactor (12,500 L) with Rushton turbine and pitched-blade (RT-PB) impeller configuration. Experimentally obtained data are used for the validation of comprehensive CFD scale-up study, using the Lattice-Boltzmann large eddy simulation (LB-LES) method. https://lnkd.in/gQy-_CbE #aspenalert #biotech #bioprocess

There's still life in those Old mass spec instruments. Here Leach et al describes a field-based upgrade which can provide extension for the usable lifespan of such older analytical instrumentation. 🎯Summary: To quote Leach et al ,"We also demonstrate, perhaps, the unexpected ability of these legacy platforms to detect usable time-domain signals up to 5 s in duration to achieve a mass resolving power 8× higher than the original platform spec" #massspectrometry #massspec #lcms #biopharmaceutical #biotherapeutic #pharma #lcms ##upcycling #greenchemistry #greenscience #science #scienceandtechnology

Great article for anyone who wants to give their LTQ-Orbitrap a second life.

My review on "Recent Advances in Fluoroalkylation Strategies: Exploring Novel Reactivities and Synthetic Applications of Sulfone-and Sulfinate-Based Reagents for Mono-, Di-, and Trifluoromethylation" has just been published in SYNTHESIS Journal Thieme If you're curious about the latest breakthroughs in fluoroalkylation strategies and how sulfone and sulfinate reagents are being utilized to introduce valuable fluorinated motifs like -CH2F, CF2H, and -CF3, this review might be of interest for you! These methodologies summarized in this review article are crucial for altering and fine-tune molecular properties, which is of immense importance for drug discovery purposes. This review provides a comprehensive summary of the current state-of-the-art research and hopefully inspires future advancements in these areas. 🔗 https://lnkd.in/eNj2cKa7 #OrganicChemistry #FluorineChemistry #Synthesis #Pharmaceuticals #Agrochemicals #Fluoroalkylation #DrugDiscovery

🔬 New Research Alert! published in #DrugDevIndPharm. 🌟 " Design, optimization and pharmaceutical characterization of wound healing film dressings with chloramphenicol and ibuprofen " 🌟 This research article focuses on the optimization of a film formulation for wound healing dressings. The study uses the Design of Experiments (DOE) approach to investigate the impact of various factors on the mechanical properties of the films. The aim is to predict an optimal formulation based on these results. The article also discusses the testing of the final product in terms of film dimensions, adhesive properties, mechanical profile, and other characteristics such as tensile properties, swelling behavior, Water vapor transmission rate (WVtR), surface morphology, thermal behavior, wettability, in vitro release of APIs, in vitro cell viability, and antibacterial activity. The results of the study are analyzed using statistical parameters and regression equations to determine the influence of the formulation factors on film properties. 📖 Read the full article here: https://lnkd.in/gt3E4tQg #WoundHealing #FilmDressings

GOING TO THE ACS FALL MEETING IN DENVER? Have an early start on Sunday, August 18 at 8:05 am and listen to David Cantillo present the #OPRD outstanding publication of the year award lecture: "Spinning electrode electrochemical cells: An efficient and versatile technology for the scale-up of electro-organic synthesis". Learn more about a compact reactor employing a spinning electrode concept that permits scaling electrochemical transformations from the milligram scale to kilogram quantities without the need for re‑optimization of reaction conditions. The reactor can operate both in batch and continuous mode, can process slurries and handle gas evolution. The technology has been demonstrated for the electrosynthesis of several key API intermediates, including adrenosterone and noroxycodone. 👉Award winning paper and first disclosure of the reactor with several applications here: https://lnkd.in/dX_gS-8n 👉Case study with Pfizer: https://lnkd.in/d2w_yHdB 👉Case study with Merck: https://lnkd.in/dZqUbsW4 👉Case study with Eli Lilly and Company: https://shorturl.at/yLM1E We are looking forward to meet you in Denver! The reactor has been developed at University of Graz and RCPE - Research Center Pharmaceutical Engineering GmbH. #electrochemistry #continuousmanufacturing #activepharmaceuticalingredient #greenchemistry

Revolutionize your biopharma plant design with process simulation! Join ISPE on July 25th for a FREE webinar for members ($50 for non-members) as Angelo Bernardis explores the future of process simulation modelling in modern biopharma plants. Don't miss this opportunity to gain valuable insights and stay ahead of the curve. Learn more and Register at: https://lnkd.in/grfssbFs #ISPE #biopharma #processimulation #webinar #ISPEAustralasia