Dimitrios Kalogeropoulos’ Post

Real-time identification of life-threatening necrotizing soft-tissue infections using indocyanine green fluorescence imaging Significance: Necrotizing soft-tissue infections (NSTIs) are life-threatening infections with a cumulative case fatality rate of 21%. The initial presentation of an NSTI is non-specific, frequently leading to misdiagnosis and delays in care. No current strategies yield an accurate, real-time diagnosis of an NSTI. Aim: A first-in-kind, observational, clinical pilot study tested the hypothesis that measurable fluorescence signal voids occur in NSTI-affected tissues following intravenous administration and imaging of perfusion-based indocyanine green (ICG) fluorescence. This hypothesis is based on the established knowledge that NSTI is associated with local microvascular thrombosis. All NSTI cases exhibited prominent fluorescence signal voids in affected tissues, including tissue features not visible to the naked eye. All cellulitis cases exhibited a hyperemic response with increased fluorescence and no distinct signal voids. Median lesion-to-background tissue SBRs based on snapshot, IS, TTP, and IMAX parameter maps ranged from 3.2 to 9.1, 2.2 to 33.8, 1.0 to 7.5, and 1.5 to 12.7, respectively, for the NSTI patient group. All fluorescence parameters except TTP demonstrated statistically significant differences between NSTI and cellulitis patient groups. Conclusions: Real-time, accurate discrimination of NSTIs compared with non-necrotizing infections may be possible with perfusion-based ICG fluorescence imaging. https://lnkd.in/d_CBEXKW Samuel Streeter Eric Henderson Gabrielle S Ray, Logan M Bateman, Jonathan Thomas Elliott, Dartmouth College Dartmouth Health #ICG #indocyaninegreen #fluorescence #fluorescent #guidedsurgery #surgery #surgeon #imaging #thinkgreen #patients #safety #surgical

Transperineal biopsies offer significant advantages over transrectal biopsies, including reduced infection and rectal injury risks. Clear Guide Medical's TP solution provides millimeter accuracy with AR guidance, enabling precise targeting of prostate lesions. This innovative approach allows for single-session pathology reports and cryo-ablation, enhancing patient outcomes and comfort. Discover the new standard of care for prostate diagnosis and treatment with Clear Guide's MR-guided TP solution.

Parasagittal and Parafalcine MENINGIOMAS : UPFRONT vs ADJUVANT RADIOSURGERY; a systematic review and meta-analysis Fernando De Nigris Vasconcellos et al., Neurosurg Rev, 2024 Mar https://lnkd.in/di5xMha9 8 studies involving 821 patients with 878 parafalcine and parasagittal (PFPS) grade I meningiomas - LOCAL CONTROL (LC) was achieved in >80% of all cases, while in the subgroup of patients that recieved UPFRONT SRS LC was achieved in 97% of such cases - TOXICITY was reported in 7.3% of the SRS treated PFPS meningiomas - RECURRENCE was observed in 17.1% of cases - FURTHER SURGICAL APPROACH was needed in 9.2% of cases - SYMPTOM IMPROVEMENT was noted in 33.2% of patients Conclusions: SRS is a SAFE and EFFECTIVE treatment for PFPS meningiomas, both as an adjuvant therapy and as an upfront treatment for often smaller tumors. The use of single and hypofractionated SRS for larger volume PFPS meningiomas should be more explored to better define the risks and benefits. #SRS #upfront_SRS #adjuvant_SRS #parafalcine #parasagittal #meningiomas

🎉 New Publication 🎉 We’re excited to share our latest manuscript published in Langenbeck's Archives of Surgery, showing that our in-development stage TriVerity Classifier (version IMX-BVN-3b) identified bacterial infections in liver transplant patients earlier than routine biomarkers.     We look forward to conducting more studies to demonstrate the ability of our host-response classifiers to rapidly and accurately identify infections in liver transplant and other immunocompromised patients as early as possible. If successful, this would provide medical professionals with important information to enhance treatment decision making. 📚 Read the full publication: [https://lnkd.in/ewe9J5bP] Follow us to stay updated on more innovative research! #HealthcareInnovation #Diagnostics #LiverTransplant #Immunocompromised #Inflammatix #MedicalResearch #PatientCare

NBC News showcases the importance of biofilm management in reducing colon cancer. How can we do better as clinicians❓ ✅ Recognize inflammation as abnormal and properly treat ✅ Dig deeper into the root cause ✅ Educate on the importance of proper brushing and interdental cleaning ✅ Bacterial testing to identify specific bacteria present in the patient's mouth. ✅ Antibiotic therapy to reduce the biofilm burden ✅ More FREQUENT biofilm control (do not let insurance dictate our recommended treatment for the individual's overall health.) ✅ Recommend products and services that promote symbiosis and prevent adhesion of biofilm to tooth surfaces. #biofilmmanagement #oralsystemicconnection #dentalhygiene #dentalhygienists #dentists #dental #cancerprevention Mary Hughes RDH, BS Stephanie Palmer https://lnkd.in/gYSRQvGG

Day On MSCT Another week has passed, the same cases and others are similar. 1️⃣ Female 26Y Sarcoiliac Synovial sarcoma excision was done, Recurrance of sarcoma twice Done excision twice PET CT👉🏼 Mets to lung & Liver, Chemotherapy..😔 👉🏼👉🏼 Doctor's Diagnosis ⚫Innumerable variable sized bilateral lung parenchymal nodules and masses are seen the largest on the right measuring 5x7.5cm…metastatic lesions. ⚫Bilateral moderate pleural effusion is seen with consolidation collapse of the related lung segments. ⚫Mild pericardial effusion. ⚫Ascites and dilated GB are seen. 2️⃣ Male 51Y Severe Abdominal Pain, Vomiting suspected Pancreatitis. Pancreatic Protocol reconstruction Had done and producet Renal Angiogram - Urography MPR 👉🏼👉🏼 Doctor's Diagnosis ⚫Mild dilated CBD with prominent pancreatic duct & no detected pancreatic focal lesions…For further EUS assessment if clinically indicated… ⚫Diffuse circumferential mural wall thickening of small bowels prominent at terminal ileum with skip lesions and minimal pelvic free fluids…Inflammatory bowel disease (Crohn’s disease) to be considered…. For clinical correlation and further histopathological assess… ⚫Bilateral suprarenal nodules…likely adenomas. ⚫Mild hepatomegaly. ⚫LT renal stones & Few bilateral small cortical renal cysts. ⚫Pattern of cystitis & mild enlarged prostate. 3️⃣ Female 63 status post extended right hemicolectomy with ileo-descending anastomosis of a known case of transverse colon adenocarcinoma suspected leakage. 👉🏼👉🏼 Doctor's Diagnosis ⚫The ileo-descending anastomosis shows no evident surrounding sizeable collections or contrast leakage, with mild dilatation and circumferential mural thickening of the afferent limb of ileal loops reaching up to 7 mm (likely post-operative edema tous changes). ⚫Mild free mainly left peri-renal , posterior para-renal , left para-colic and to a lesser extent peri-splenic, lesser sac and anterior peri-hepatic pneumoperitoneum, likely post- operative sequels. ⚫Mild free abdomino-pelvic ascites. ⚫Bilateral mild pleural effusions ⚫Liver: Normal size. Normal attenuation features. Left hepatic lobe hypodense focal lesions are noted adjacent of the falciform ligament showing no considerable enhancement on either arterial or porto-venous phases suggesting focal areas of fatty infiltration (for follow up). ⚫Another small 5 mm caudate lobe para-caval non- enhancing hypodense lesion, likely representing hepatic cyst , for follow up. ⚫Gallbladder and biliary tree: shows multiple millimetric dense stones intermingled with minimal biliary mud. ⚫Adrenals: a well-defined right supra-renal rounded focal lesions measuring 1.1 cm along maximum diameters, presenting HU of 9 on non-contrast images ( less than 10) denoting lipid rich adenoma. #MSCT #siemenshealthineers #siemens #computedtomography #angiography #surgery #cancer #ICU #radiographer #hospital #radiology

Early Cancer Detection and Prevention How your Dentist can help! by Dr. Cynthia Stephenson, DDS Early Detection can be lifesaving! 650,000 people are diagnosed with oral, head, and neck cancers each year, resulting in 330,000 deaths. Early detection, however, significantly improves survival rates. Dentists are trained to do a thorough oral cancer screening EVERY time you sit down in the chair, whether it is for cleanings, fillings, or simply whitening. We are trained to examine your mouth first thing. Veloscope- a pain free, quick, no cost tool. A blue light stimulates fluorescence identifying cellular changes before they are visible to the naked eye. Toluidine Blue swabs blue stain that binds with tissues that have cellular changes including mucosal dysplasia or pre-malignant lesions. This helps the dental professional target regions for further evaluation. Click to read more.... https://lnkd.in/gm6nGptR

Optic Nerve Head Infiltration in Presumed Tuberculous Uveitis To report the clinical and multimodal imaging findings of presumed tuberculous optic nerve head (ONH) infiltration in 3 patients at a tertiary eye care center. In addition to unilateral presumed tuberculous ONH infiltration, all patients had clinical findings suggestive of tuberculous choroidal involvement which was confirmed by Indocyanine green angiography (ICGA). All patients were treated successfully with a combination of antituberculous regimen and systemic corticosteroids. Previous reports of tuberculous ONH granuloma have been described in patients suffering from miliary TB.Our cases differ from earlier reports in that all had no active pulmonary TB, the anterior segment examination was completely normal, and vitritis was absent. It is noteworthy that the ICG demonstrated that the choroidal involvement was more extensive than what was seen clinically. Recently, ICGA has been shown to be helpful in detecting subclinical choroidal involvement that is not evident by fundus examination or fluorescein angiography in patients with Presumed intraocular tuberculosis (PIOTB). https://lnkd.in/eVJpNsC2 Marwan Abouammoh Lojain Azizalrahman Abdulrahman Albloushi Ahmed Abu El-Asrar King Saud University #ICG #indocyaninegreen #fluorescence #fluorescent #guidedsurgery #surgery #surgeon #imaging #thinkgreen #angiography #patients

📃Scientific paper: Association between Thyroid Function and Ocular Parameters Abstract: SIMPLE SUMMARY: The scope of this study was to determine if various ocular parameters are associated with parameters indicating thyroid activity. It is well-known that in some pathological thyroid conditions, the eyes can also be affected. Thyroid eye disease is the most extreme example of eye pathology caused by a pathological thyroid condition. In the current study, we measured the plasma levels of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), thyroglobulin (Tg), thyroglobulin antibodies (TgAb), and thyroid peroxidase antibodies (TPOAb), in addition to 20 ocular parameters in 4633 healthy adults (10 for each eye, including corneal radius, corneal thickness, anterior chamber depth, anterior chamber angle, lens thickness, posterior chamber length, axial length, intraocular lens power (IOL), spherical power, and cylinder power). This is, to the best of our knowledge, the largest study inferring the effect of thyroid activity on ocular parameters. The most important result of this study was that patients with hyperthyroidism had thicker corneas compared to euthyroid individuals. Intraocular lens power was increased in patients with clinical hypothyroidism, while spherical power was increased in euthyroid individuals with positive antibodies. The diagnostic potential of corneal thickness monitoring in patients with hyperthyroidism, which could indicate the later development of thyroid-related eye disease, should be explored in lon... Continued on ES/IODE ➡️ https://etcse.fr/V0t ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Association between Thyroid Function and Ocular Parameters Abstract: SIMPLE SUMMARY: The scope of this study was to determine if various ocular parameters are associated with parameters indicating thyroid activity. It is well-known that in some pathological thyroid conditions, the eyes can also be affected. Thyroid eye disease is the most extreme example of eye pathology caused by a pathological thyroid condition. In the current study, we measured the plasma levels of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), thyroglobulin (Tg), thyroglobulin antibodies (TgAb), and thyroid peroxidase antibodies (TPOAb), in addition to 20 ocular parameters in 4633 healthy adults (10 for each eye, including corneal radius, corneal thickness, anterior chamber depth, anterior chamber angle, lens thickness, posterior chamber length, axial length, intraocular lens power (IOL), spherical power, and cylinder power). This is, to the best of our knowledge, the largest study inferring the effect of thyroid activity on ocular parameters. The most important result of this study was that patients with hyperthyroidism had thicker corneas compared to euthyroid individuals. Intraocular lens power was increased in patients with clinical hypothyroidism, while spherical power was increased in euthyroid individuals with positive antibodies. The diagnostic potential of corneal thickness monitoring in patients with hyperthyroidism, which could indicate the later development of thyroid-related eye disease, should be explored in lon... Continued on ES/IODE ➡️ https://etcse.fr/V0t ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.