Leukopak Quality Impacts T-Cell Expansion and CAR-T Cell Therapy. How?
One example is high granulocyte levels in a leukopak reducing ex vivo T cell expansion, a key step in CAR-T cell production, resulting in lower yields of viable target T cells. This can compromise downstream steps and diminish the likelihood of achieving therapeutic goals.
Cell therapy developers should choose vendors who can control the end to end process and provide robust donor characterization, stringent collection protocols, and scalable processes as well as also offer continuity from research-use-only (RUO) to GMP leukopaks collected under the same high standards.
This minimizes variability and contamination, supporting CAR-T development and manufacturing across all stages, from discovery to commercial production providing a higher likelihood of commercial and patient success.
Granulocyte contamination in leukopaks is a major issue in CAR-T cell development, affecting T cell expansion, functionality, and clinical efficacy. Granulocyte contamination and leukopak quality are closely linked, and smart donor selection combined with optimized leukapheresis protocols can significantly enhance overall quality.
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