Stramenopiles are unusual because the pay-off phase of glycolysis occurs in mitochondria rather than the cytosol and the identified mitochondrial carrier links the two parts by transporting glycolytic intermediates. https://lnkd.in/eYbZ6SUH
eLife Sciences Publications, Ltd.’s Post
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A very interesting work by Velema et al. about a new delivery method of antisense oligonucleotides into bacteria via conjugation to siderophores via a siderophore-mediated iron uptake pathway.
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https://lnkd.in/e3qEBSaN The combination of a riboflavin-derived organocatalyst and molecular iodine successfully promoted the aerobic oxidation of thiols to disulfides
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https://lnkd.in/e3viS7hp The combination of a riboflavin-derived organocatalyst and molecular iodine successfully promoted the aerobic oxidation of thiols to disulfides
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🌟 Innovative! A new VHL molecular glue degrader for cysteine dioxygenase 1, diverging from CRBN glues. This breakthrough marks a potential start to a new era in targeted protein degradation. Exciting times! 🧬🔍 #protein #degradation #biotechinnovation #researchadvancements ✨🔬
A small molecule VHL molecular glue degrader for cysteine dioxygenase 1 Diverging from conventional CRBN glues, comes a groundbreaking molecular glue not related to zinc fingers selectively degrading proteins via the VHL E3 ligase. Probably a start of a New era in targeted protein degradation. https://lnkd.in/gxqqZCTP
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Medical laboratories specialist | Molecular biology and forensic genetics | Membership in the Saudi Society for Molecular Biology and Biotech
Problems we face in #DNA_extraction and their reason: 🔴Little or no #DNA in the eluate? -reason- 1-Low concentration of cells in the sample. 2-Inefficient cell lysis insufficient mixing with Buffer AL. 3- Inefficient cell lysis due to decreased protease activity. 4-No ethanol added to the lysate before loading onto the QIAamp column. 5-Buffer AW1 or Buffer AW2 prepared incorrectly. 6-Water used instead of Buffer AE for elution. 🛑Low concentration of #DNA in the eluate? 1-Second elution step diluted the DNA
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The Suzuki–Miyaura and Buchwald–Hartwig coupling reactions are widely used to form carbon-carbon (C–C) and carbon-nitrogen (C–N) bonds, respectively. Liu et al. report the incorporation of a formal nitrene insertion process into the Suzuki–Miyaura reaction, altering the products from C–C–linked biaryls to C–N–C–linked diaryl amines and thereby joining the Suzuki–Miyaura and Buchwald–Hartwig coupling pathways to the same starting-material classes. A combination of a bulky ancillary phosphine ligand on palladium and a commercially available amination reagent enables efficient reactivity across aryl halides and pseudohalides, boronic acids and esters, and many functional groups and heterocycles. Mechanistic insights reveal flexibility on the order of bond-forming events, suggesting potential for expansion of the aminative cross-coupling concept to encompass diverse nucleophiles and electrophiles as well as four-component variants.
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PRODUCT NAME: Nena – Zone 250mg Inj GENERIC NAME: Cefoperazone Sodium (Vial) PACK SIZE: 1’s x 250 mg SUMMARY: It is a semi-synthetic broad spectrum, beta-lactamase resistant ,third generation Cephalosporin anti biotic with bacteriocidal activity MODE OF ACTION: It acts by inhibiting the bacterial cell wall synthesis
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Yeast Xrn1-sensitive unstable lncRNAs contain ribosome-associated small ORFs and are pervasively translated before being degraded by NMD, while lncRNA-derived peptides could exist in the cell. https://bit.ly/4bu93lu
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Lead- Physicochemical characterization-complex generics, Formulation Analytical R&D injectables, Eugia Pharma
Interesting read on monitoring #Oligonucleotide #size distribution using SEC-UV, SEC-MS and SEC-MALS for identification of impurities such as n-1, n-2, n+1,... oligonucleotides. https://lnkd.in/guj2Gfhy
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Restriction endonuclease and average fragment length A restriction enzyme or restriction endonuclease is an enzyme that cleaves DNA into fragments at or near specific recognition sites within the molecule known as restriction sites. Restrictions enzymes are one class of the broader endonuclease group of enzymes. Youtube video: https://lnkd.in/dvt7PJNz #nikolaysgeneticslessons
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