Emma Petrović’s Post

At Endogena Therapeutics, Inc., we are revolutionizing treatment for retinal diseases! Check out our recent publication to learn how we used a single #smallmolecule to restore vision in a mouse model of retinal degeneration. #scientificresearch #regenerativemedicine #stemcells #drugdiscovery #clinicaltrials

The October issue of Cell Press Trends in Pharmacological Sciences is now available online! Explore the latest insights on various topics including targeting white adipose tissue for combating insulin resistance, SYK targeting in solid tumors, and quantum computing applications in clinical trial design(Hakan Doga, PhD, Aritra Bose, Daniel Blankenberg). Don't miss the Drug of the Month highlighting Ensifentrine for chronic obstructive pulmonary disease (Sandra HUBERT,Ayrin KÖK-CARRIERE, &Frédéric De Ceuninck). Reach out to me on here or at the Trends in Pharmacological Sciences website if you have an idea for a Drug of the Month, Scientific Life, Opinion, or Review article you wish to publish. #Pharmacology #Research #DrugDiscovery #ScienceCommunity

Revolutionizing Medicine: Human iPS Cell Chemical Reprogramming Kit Cellular reprogramming tools can manipulate cell identity, enabling the generation of desired cell types that provide broad applications in disease modeling, drug discovery and regenerative medicine. Chemical reprogramming approach synergistically targets cell signaling pathways and epigenetic modifiers without gene manipulation, and offers considerable advantages for the development of pharmacological and therapeutic strategies. Recently, a new scalable, efficient, and rapid chemical reprogramming approach was reported, which can induce human somatic cells into pluripotent stem cells (Guan, J et al., Nature, 2022; Liuyang, S et al., Cell Stem Cell, 2023). This kit, optimized from a patent in filing (METHODS FOR CHEMICAL REPROGRAMMING AND PLURIPOTENT STEM CELLS, PCT/CN2022/124960) and publication (Liuyang, S et al., Cell Stem Cell, 2023), can be used to generate human chemically induced pluripotent stem cell (hCiPSCs) from human adult adipose-derived stromal cells (hADSC) or skin dermal fibroblasts (HDFs).

📢Daily Paper Sharing: Advances in rationally engineered cytokines for precision therapy in diabetic wound healing hashtag #diabetic #wound 👥 Authors: Xinxin Zhang, Tingting Wang, Xiangqing Fan, Tianze Zhang, Rui Qiu, Yuqi Wu, Meixia Wang, Yizhi Zhang, Meng Li, Na Cai , Ying Guan, Hong-Hui Wang 🔑 Keywords: Cytokine engineering, diabetic wound healing, precision therapy, synthetic biology, rationally designed cytokines, molecular modifications 🎯 "...This review not only provides valuable perspectives on the future research directions but also offers insights into the potential clinical applications of these innovative therapies, aiming to significantly improve the outcomes for patients suffering from diabetic wounds." 👤 Academic Editor: Dominique J. Charron, Hospital Saint Louis, France 🔗 Read the full article: https://lnkd.in/gpBpk8VY

🔬 Cutting-edge Research Share! 🔥 Diabetic wound healing takes a leap with rational cytokine engineering! 🩹 Driven by Xinxin Zhang et al., explore precision therapies that merge #syntheticbiology & molecular wizardry. A must-read for healthcare innovators! 🌟 #DiabeticWound #PrecisionMedicine

🚀 Researchers from the University of Pennsylvania have unveiled a game-changing “one-pot platform” for lightning-fast synthesis of lipid nanoparticles (LNPs) that deliver mRNA with pinpoint precision. Using cutting-edge amidine-incorporated degradable (AID) lipids and “click-like chemistry,” they’ve slashed synthesis time from weeks to just hours. This innovation promises targeted treatments for diseases in organs like the liver, lungs, and spleen, opening new frontiers in medicine. Dive into the future of mRNA delivery and therapeutic possibilities. #BiotechRevolution #mRNA #MedicalBreakthrough #LipidNanoparticles Read more: https://lnkd.in/eeGdBcNF

TB 500, also known as Thymosin Beta 4 peptide, is a synthetic peptide. It is derived from a protein called Thymosin Beta 4 and is made up of 43-amino acid chain. TB 500 plays a crucial role in cell migration, tissue repair, and wound healing processes. This peptide is obtained through laboratory synthesis and has promising potential in regenerative medicine. We can administer TB 500 via subcutaneous injection. Due to its healing ability, TB 500 has gained significant interest in various medical and research applications. (Bock-Marquette et al. 2023) You can legally buy TB 500 at NuScience Peptides here. But how does TB 500 work? Let’s understand its mechanism of action.

📢Daily Paper Sharing: Advances in rationally engineered cytokines for precision therapy in diabetic wound healing hashtag #diabetic #wound 👥 Authors: Xinxin Zhang, Tingting Wang, Xiangqing Fan, Tianze Zhang, Rui Qiu, Yuqi Wu, Meixia Wang, Yizhi Zhang, Meng Li, Na Cai , Ying Guan, Hong-Hui Wang 🔑 Keywords: Cytokine engineering, diabetic wound healing, precision therapy, synthetic biology, rationally designed cytokines, molecular modifications 🎯 "...This review not only provides valuable perspectives on the future research directions but also offers insights into the potential clinical applications of these innovative therapies, aiming to significantly improve the outcomes for patients suffering from diabetic wounds." 👤 Academic Editor: Dominique J. Charron, Hospital Saint Louis, France 🔗 Read the full article: https://lnkd.in/geqfCwRZ

🌟 DIVA-BIObank! 💼💉 Bring DIVA's expertise into your lab and unlock the potential of adipose tissue research. DIVA-BIObank offers a comprehensive range of human adipose tissue and 3D-layer skin products. From primary cells (including fibroblasts, preadipocytes, and precursors) to conditioned media and histological sections, we provide essential materials for your preclinical research needs, especially in studies related to obesity and metabolic complications. 🔎What sets DIVA-BIObank apart? With a diverse pool of volunteers and guaranteed availability, we ensure seamless support for your research endeavors. Our products enable you to generate scientific data that closely mimics clinical assays, enhancing the success of your research outcomes. 📣 Exciting news for preadipocytes enthusiasts: DIVA-BIObank boasts over 2000 ampoules from more than 350 donors, each with unique characteristics. For fibroblasts, we offer over 1700 ampoules from over 300 donors, providing unparalleled diversity and quality for your experiments. Ready to take your research to the next level? Contact us today to learn more about how DIVA-BIObank can empower your scientific discoveries! 🔬 #DIVAExpertise #DIVABIObank #Research #AdiposeTissue #PreclinicalResearch #ScientificDiscovery #Obesity #MetabolicComplications

🔬Citation Break!📖 This citation investigates the relationship between Beta-Amyloid peptides and extracellular vesicles (EVs). The researchers wish to show how forms of Aβ might travel throughout the body, and how this process might be involved in the pathology of Alzheimer's Disease. Several rPeptide products were used for the authors’ experiments, SIMOA assays, and other analyses during their research: Beta-Amyloid (1-40) and (1-42) NaOH (A-1155 and A-1165) and sequence scrambled versions of each (A-1003 and A-1004). Paper: https://t.ly/b0LFC Beta-Amyloid Products: https://t.ly/w-f7N #Research #Development #rPeptide #Alzheimers #Experiment #NaOH #Scrambled #BetaAmyloid