EphyX Neuroscience’s Post

Today, we highlight a powerful tool that reshaped the landscape of neuroscience research: in vitro optogenetics. 💫 This innovative technique empowers researchers to selectively activate or suppress specific neuronal populations with unparalleled precision. 💫 In vitro optogenetics operates by engineering neurons to express light-responsive opsins or via viral transfection. 💫 This method can be effortlessly combined with whole-cell patch clamp, extracellular recordings and/or imaging techniques enabling in-depth synaptic analysis of mechanisms of action (MOA). At Ephyx Neuroscience, we pride ourselves on offering exceptional in vitro optogenetics services to help you get detailed and relevant insights in your project. Our dedicated team of experts is committed to delivering dependable, high-quality data to propel your projects to new heights. Should you have any questions about our services or wish to discuss how in vitro optogenetics can enhance your research, please feel free to contact us at contact@ephyx-neuroscience.com. #Electrophysiology #DrugDiscovery #CNSResearch #DrugDevelopment #PreclinicalResearch #ResearchAndDevelopment #Neurophysiology #CentralNervousSystem #Neuroscience #CRO #Pharma #ContractResearch

Electrophysiology serves as a fundamental tool in the investigation of epilepsy, providing valuable insights into the underlying mechanisms of this complex neurological disorder. At EphyX Neuroscience, we routinely employ a range of epilepsy in vitro models including transgenic rodents and/or pharmacologically-induced epileptiform activity to test the effects of drug candidates. Below is a short example of what can be expected qualitatively from single cell recording of a CA1 pyramidal cell and pharmacological induction of epileptiform activity in P30 C57/Bl6 mouse acute brain slice using a combination of low magnesium and gabazine. The top panel (A) shows the spontaneous bursts of action potentials (APs) elicited in this condition compared to baseline standard ACSF. The bottom panel (B) shows the hyperexcitability of the cell when eliciting action potentials. Typical analysis would focus on the APs frequency, threshold, height and half-width but we adapt to your needs to extract and analyse the most relevant parameters for your project. Don't hesitate to contact us at contact@ephyx-neuroscience.com to discuss your epilepsy research projects or if you would like to see more thorough sample data on the subject. #Electrophysiology #DrugDiscovery #CNSResearch #DrugDevelopment #PreclinicalResearch #ResearchAndDevelopment #Neurophysiology #CentralNervousSystem #Neuroscience #CRO #Pharma #ContractResearch #Epilepsy

It's the last day to submit your research for a chance to win the 2024 Best Negative Data Prize in Preclinical Neuroscience. The prize recognizes the researcher or research group whose publication in preclinical neuroscience best exemplifies data where the results do not confirm the expected outcomes or original hypotheses, or results that challenge a long-standing precedent. Submit your publication today: https://lnkd.in/dcaQ29pf #openscience #preclinical #neuroscience Global Preclinical Data Forum European College of Neuropsychopharmacology (ECNP)

🧠 Epilepsy Insights with Brain Slice Electrophysiology 🧠 At EphyX Neuroscience, we leverage brain slice electrophysiology to create a physiologically relevant environment for studying various pathological conditions and evaluating the impact of your lead compounds on neuron-specific activities. This approach yields highly valuable functional insights. For example, we routinely employ a range of in vitro models to assess the potential of test compounds and their mechanisms of action in the context of epileptic seizures. One notable model utilizes Oxotremorine, a muscarinic acetylcholine receptor agonist that mimics the hyperactivity observed during epileptic seizures. By selectively activating cholinergic pathways, Oxotremorine enhances neuronal intrinsic excitability. This effect is clearly demonstrated through whole-cell patch-clamp recordings of a CA1 pyramidal cell before and after Oxotremorine application: increased firing frequency for a given current injection step, and the generation of spontaneous bursts of action potentials. Interested in discussing your seizure-related research projects or exploring more thorough sample data on the subject? Don't hesitate to reach out to us at contact@ephyx-neuroscience.com. #Electrophysiology #DrugDiscovery #CNSResearch #DrugDevelopment #PreclinicalResearch #ResearchAndDevelopment #Neurophysiology #CentralNervousSystem #Neuroscience #CRO #Pharma #ContractResearch #Epilepsy #EpilepsyResearch #inVitroModel

I’ll be presenting our first poster today on Neuroplastogen effects of psychedelics in neuronal primary cell cultures and the chronic mild stress model in rats, in collaboration with Gilgamesh Pharmaceuticals. If you’re interested in learning more about the effects of Ketamine and Psilocybin on PSD-95 Scholl Analysis and microtubule dynamics, come visit me! 📍 Board B62 - Oct 5, 1-5 PM Poster title: “Plastinogenic Effects of Ketamine on Primary Mouse Cortical Neurons: Establishing a Platform for Novel Antidepressant Discovery” Ulysses Neuroscience Limited your Vanguard CRO and Translational Partner #Neuroscience #SfN2024 #Psychedelics #Neuroplasticity #Ketamine #Psilocybin #DepressionResearch #DrugDiscovery #CRO #SynapticPlasticity #MentalHealth

Attention preclinical neuroscience researchers! Submit your work for a chance to win the 2024 Best Negative Data Prize. We're honoring preclinical research that best exemplifies data where the results do not confirm the expected outcomes or original hypotheses, or results that challenge a long-standing precedent. Global Preclinical Data Forum& European College of Neuropsychopharmacology (ECNP). Learn more and enter here: https://lnkd.in/dcaQ29pf #preclinicalresearch #neuroscience #openscience

🧠Attention to all the #neuroscience researchers in my network!🧠 Looking for an ideal method to grow beautiful brain organoids? Check out this resource that provides valuable insights on growing brain organoids. https://lnkd.in/egZhJQzy #brainhealth #neuroscience #biotech #lifescience #braincancer

Multiple Sclerosis (MS) is a complex disease of the central nervous system characterized by demyelination and inflammation. Although its pathogenesis remains unclear, Experimental Autoimmune Encephalomyelitis (EAE) is the most studied model for the disease. MD Bioproducts offers highly purified myelin oligodendrocyte glycoprotein (MOG) for MOG-induced EAE models in mice and rats for CNS research discoveries. Contact us to learn more about our products to support your neuroscience research. Product Link: https://lnkd.in/dpu6Mc5t #mdbioproducts #CNSresearch #MSresearch #neuroscience #MultipleSclerosis #demyelination #autoimmunedisease #neuroinflammation #research #preclinical #EAE #drugdiscovery #invivo

Sign up for The Lipidomics Webinar for Neuroscience --- Mark Your Calendar! Join us for "Lipidomics and lipids in neuroscience: The Lipidomics Webinar #13" presented by Dr. Dr. Olya Vvedenskaya on Thursday, October 24, 2024, at 5:00 pm (Europe/Berlin time). Key Takeaways from Our Webinar on Lipidomics in Neuroscience: • Role of lipids in myelination and remyelination • Lipases and Parkinson’s disease • Lipid biomarkers for multiple sclerosis • Multiomics of Alzheimer’s disease Secure your spot now! 👉 https://lnkd.in/eAcRPFFZ #Neuroscience #Lipidomics #Lipotype #BrainHealth #Neurodegeneration #Alzheimers #ParkinsonsDisease #MultipleSclerosis #BrainScience #LipidBiomarkers #Multiomics

Just Published: Our new Lab Note on performing Calcium Flux assays with our new iCell Sensory Neurons. Let me know if you want to discuss how our iCell Sensory Neurons can help your pain research