European Annals of Allergy and Clinical Immunology’s Post

'IBD HAS NO BORDERS' The focus of #WorldIBDDay2024 is on strengthening global alliances and increasing collective impact in our ongoing fight against #InflammatoryBowelDisease. In #ImmUniverse we unite 26 Partners from 10 Countries in order to better understand the needs of people living with #IBD, our ImmUniverse includes three European patient associations that make patient’s experiences and concerns their daily business. 1️⃣ European Federation of Crohn's and Ulcerative Colitis Associations 2️⃣ European Federation of Allergy and Airways Diseases Patients' Associations (EFA) 3️⃣ European Patients' Forum 👉 https://lnkd.in/dgnUymy7 “ImmUniverse aims not only to identify disease-specific signatures, but also cross-disease signatures of the underlying pathological pathways between ulcerative colitis and atopic dermatitis using multiomic approaches. The validation of new disrupted liquid biopsies for the molecular characterization of the skin and colon will allow us to non-invasively monitor the response to treatment and disease progression in our patients”, says Dr Stefania Vetrano, Assistant Professor of Gastroenterology at Humanitas Research Hospital University in Milan, Italy, and scientific coordinator of ImmUniverse. #ibdhasnoborders #worldibdday2024

Eosinophil count is a blood test that measures the number of eosinophils, a type of white blood cell, in your blood. Eosinophils play a crucial role in the body's immune response, particularly in fighting infections and participating in allergic reactions. Key Points About Eosinophil Count: - Purpose: This test helps diagnose and monitor conditions such as infections, allergic reactions, and certain autoimmune diseases¹². - Normal Range: Typically, a normal eosinophil count is less than 500 cells per microliter (µL) of blood, or less than 5% of the total white blood cell count²³. - High Eosinophil Count: Elevated levels, known as eosinophilia, can indicate conditions like allergies, asthma, parasitic infections, and certain types of cancer²³. - Low Eosinophil Count: Lower-than-normal levels can be seen in conditions like acute infections or as a result of certain medications³. Clinical Significance: - Diagnosis: An eosinophil count is often part of a complete blood count (CBC) with differential, which provides a comprehensive picture of your overall health¹². - Monitoring: It helps in tracking the progress of diseases and the effectiveness of treatments, especially in chronic conditions like asthma and autoimmune disorders¹². Conclusion: Understanding your eosinophil count can provide valuable insights into your immune system's health and help in diagnosing and managing various medical conditions. Always discuss your test results with your healthcare provider to understand what they mean for your specific health situation. #Healthcare #EosinophilCount #MedicalTesting #ImmuneSystem #MedicalLaboratoryTechnology #Microbiology #Phlebotomy #LaboratoryTesting #DiagnosticTesting #HealthcareProfessional #MedicalTesting #ClinicalLaboratory #BiomedicalScience #HealthcareIndustry #MedicalScience #LaboratoryMedicine #ClinicalMicrobiology #InfectionControl #PhlebotomyTechnician #MedicalLabTechnician #MicrobiologyLab #ClinicalLab #HealthcareCareer #MedicalCareer #ScienceCareer #COVID19Testing #Virology #Bacteriology #Parasitology #MolecularDiagnosis #GeneticTesting #Cytology #Histopathology #Immunology #Serology

Latest published paper by our researchers! 🎉 Why does antibiotic exposure in early life increase the likelihood of developing allergies and asthma in adulthood❓ We are proud to present the results of the team's seven-year study, which was published in the prestigious journal Immunity❗ 🔸 Perdijk, O., Butler, A., Macowan, M., Chatzis, R., Bulanda, E., Grant, R. D., Harris, N. L., Wypych, T. P. & Marsland, B. J. (2024) Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood. 𝘐𝘮𝘮𝘶𝘯𝘪𝘵𝘺, 57, 1-16. Congratulations to the authors, including those from the Nencki Institute: Edyta Bulanda & Tomasz Wypych! 👋 👋 🔹 Epidemiological data indicate a correlation between antibiotic intake in early life and the development of allergies and asthma in adulthood. However, the mechanisms underlying this phenomenon remain unknown. 🔸The combined efforts of authors from three Institutes (Nencki Institute of Experimental Biology of the Polish Academy of Sciences, Warsaw, CHUV | Lausanne university hospital and Monash University) may pave the way to developing strategies to mitigate the detrimental effects of antibiotic treatment in early life. We encourage you to read the article ➡ https://lnkd.in/dtSfQSzJ

https://lnkd.in/dE3ri9ju The three endoscopic findings of white plaque, longitudinal furrows, and rings are considered important for the detection and diagnosis of EoE. Longitudinal furrows, usually located between longitudinal esophageal folds on the lower esophageal mucosal surface, are found in 90% of cases. White plaque and rings are also often observed. Compared with control populations, the prevalence of Helicobacter pylori infection has been shown to be lower in patients with EoE.  could be triggered by allergy to certain foods or environmental factors or as part of allergic susceptibility in patients who have atopic dermatitis, asthmatic attacks, or eczema. Its prevalence ranges from 0.01-0.1 per 100,000 people.Diseases that are associated with EoE include food and environmental allergies, atopic dermatitis, and asthma.

Our review "The gut–airway microbiome axis in health and respiratory diseases" is just out in Nature Reviews Microbiology. We discussed the latest literature on: -Factors influencing the development of gut and airway microbiomes -Mechanisms of gut-airway crosstalk -The gut-airway microbiomes and respiratory viral infections -The future of microbiome medicine in airway diseases It couldn't have been better timing as we just wrapped up #ATS2024 today with a talk on gut microbiome and respiratory phenotypes in inner-city children in beautiful San Diego.

Sarcoidosis What do we currently know about sarcoidosis? Sarcoidosis is thought to be a systemic inflammatory disease that affects the lungs in up to 80-90% of affected individuals. Thus, some individuals do not have lung involvement but involvement in other organs of the body (eyes, nervous system, lymph nodes, skin, liver, spleen, joints, are some examples of other organs that can be involved) One of the main motivations of our group is to understand sarcoidosis better since there are so many remaining questions. However, research thus far has revealed some important facts about sarcoidosis. First, the cause of sarcoidosis is likely complex, involving some sort of trigger, which most investigators believe may be environmental, but also involves genetic risk factors. Both of the areas are currently being investigated. Results from the largest epidemiologic study to date (the ACCESS trial), revealed that there is no one unifying environmental trigger and no one single gene mutation responsible to causing sarcoidosis. Thus, the disease is thought to be a complex genetic disease with an environmental component. What are common symptoms? Since the majority of subjects have sarcoidosis in their lungs or lymph nodes in their chest, respiratory of chest symptoms are the most common symptoms. Other symptoms that can be frustrating, debilitating and difficult to treat include symptoms of fatigue, joint pain, and vague chest pains. Some subjects, however, have no symptoms at all. Since sarcoidosis can appear in any organ, subjects may have symptoms specific to their affected organ. When a new symptom arises, it is important to inform your treating physician. The new symptom may or may not be related to sarcoidosis so communication and evaluation is always a good idea. To continue reading go to: Sarcoidosis | UCSF Pulmonary, Critical Care, Allergy and Sleep Medicine #sarcoidosis #raredisease #ourjourney #patientadvocate #sarcoidosisadvocate #mentalhealthawarenessmonth

https://lnkd.in/g6-qHEf3 Promising future for the treatment of EoE (eosinophilic esophagitis) as discovered in this recent study! Foulkes: The goal of ‘1104 is to offer superior long-term disease remission from less frequent chronic dosing without suppression of the immune system. Compared with focusing on the reduction of eosinophil infiltration or inflammatory pathways, ‘1104 has a broader mechanistic effect to address EoE’s complex pathophysiology #EoE #immuneresponse #eosinophilicesophagitis #'1104

Recent research has uncovered that individuals with allergy-induced sniffles and asthma exhibit distinct fungal communities, or mycobiomes, in their nasal passages. This study, involving 214 participants, revealed that those with allergic rhinitis and asthma have a more diverse and richer fungal presence compared to healthy individuals. The findings suggest that the nasal cavity may harbor fungi contributing to these respiratory conditions. Notably, certain metabolic pathways linked to DNA and RNA synthesis were more prevalent in affected patients, indicating potential therapeutic targets. These insights pave the way for future research into the role of fungi in respiratory diseases.

🚨 **Antibiotic Misuse During Influenza Season: A Growing Concern** 🚨 As we enter flu season, it's crucial to address a significant issue that affects public health worldwide: the misuse of antibiotics. Many people mistakenly believe that antibiotics can treat viral infections like influenza. This misconception can lead to serious consequences. 🔍 **Why This Matters:** - **Antibiotics Are Ineffective Against Viruses:** Influenza is caused by a virus, and antibiotics target bacteria. Using antibiotics for viral infections does not help and can contribute to antibiotic resistance. - **Antibiotic Resistance:** Overusing antibiotics can lead to resistant strains of bacteria, making infections harder to treat and posing a risk to patient safety. - **Health Risks:** Unnecessary antibiotics can cause side effects and disrupt healthy bacteria in our bodies. Let's work together to ensure that antibiotics are used responsibly and effectively. Protecting public health starts with informed choices! 💪🌍 #PublicHealth #Antibiotics #Influenza #HealthEducation #AntibioticResistancehttps: //https://lnkd.in/djb9uemt?

Microbiota and Immune System Interactions The interaction between the gut microbiota and the immune system is essential for maintaining health and preventing disease. Some beneficial bacteria, such as Bifidobacterium and Lactobacillus, produce short-chain fatty acids (SCFAs) like butyrate, which have anti-inflammatory properties and help regulate immune responses. In addition, these SCFAs can strengthen the intestinal barrier and prevent pathogens and toxins from transferring into the blood, thereby reducing systemic inflammation. Some studies have shown that the gut microbiota can affect both innate and adaptive immunity. For example, certain microbial metabolites can enhance the function of regulatory T cells (Tregs), which are essential for maintaining immune tolerance and preventing autoimmune diseases. Other studies have further found that an imbalance in the gut microbiota is associated with a variety of immune-related diseases, including inflammatory bowel disease (IBD), allergies, and autoimmune diseases. However, scientists still do not fully understand the detailed mechanisms of how gut microbes regulate the immune system. Further research is needed to unravel these complex interactions and develop microbiome-based therapies for immune-related diseases. Importantly, understanding these interactions opens up new therapeutic avenues, potentially leading to innovative therapies that harness the microbiome to enhance immune function and prevent disease. References [1] Danping Zheng et al., Cell Research 2020 (https://lnkd.in/eKyuGir6) [2] Ji Youn Yoo et al., Microorganisms 2020 (10.3390/microorganisms8101587) #GutMicrobiota #ImmuneSystem #SCFAs #ImmuneModulation #Tregs #Dysbiosis #IBD #AutoimmuneDiseases #HealthResearch #Microbiome #GutHealth #Inflammation #MicrobialMetabolites #Immunology #TherapeuticInterventions