Fatty Liver Alliance’s Post

[Paper Review] Intermittent fasting effects in patients with nonalcoholic fatty liver disease part2 한국어 링크 : https://lnkd.in/eBwxskp9 Changes in triglyceride content in the liver: The triglyceride content in the liver decreased in both groups. At month 6, the TRE group decreased by 8.3% and the DCR group decreased by 8.1%, At 12 months, the TRE group decreased by 6.9% and the DCR group decreased by 7.9%. The difference between the two groups was not significant. ● Liver stiffness: Liver stiffness was also reduced in both groups. TRE group decreased by 2.1 kPa and DCR group decreased by 1.7 kPa. There was no significant difference again. ● Weight Change: Both groups lost weight. The TRE group lost 8.4 kg and the DCR group lost 7.8 kg. The difference between the two groups was not significant. ● Waist circumference, body fat percentage, etc.: Both groups showed significant decrease in waist circumference and body fat percentage, but there was no difference between the two groups. ● Liver enzyme levels: Both groups had decreased liver enzyme levels (ALT, AST, GGT), but there was no difference between the two groups. ● Blood glucose and Metabolism Related Indicators: Both groups showed improvements in blood glucose and metabolic related indicators (fast blood glucose, glycated hemoglobin, insulin resistance index), but there was no difference between the two groups. At 12 months, the insulin resistance index of the TRE group improved more, but the difference between the two groups was still not significant. Conclusion: In obese patients with nonalcoholic fatty liver disease, the time-limited diet (TRE) compared to the daily calorie limit (DCR), There were no additional benefits in improving triglyceride content, weight, and metabolism-related risk factors in the liver. However, a time-limited diet may be more effective for improving insulin sensitivity. If an obese NAFLD patient goes on a time-limited diet, it is important to limit the calories consumed per day. Simply put, it didn't make much difference whether obese patients with nonalcoholic fatty liver disease were on a time-limited diet (intermittent fasting) or a daily calorie limit. Both methods helped to lose weight and improve liver health, The important thing is to control your daily calories! Why don't you try various ways to manage your weight and live a healthy life, too?

🌟 Fasting: A Powerful Tool Against Non-Alcoholic Fatty Liver Disease (NAFLD) 🌿🧠 Non-Alcoholic Fatty Liver Disease (NAFLD) is becoming one of the most common liver issues worldwide, affecting millions. It’s closely tied to obesity, poor diet, and insulin resistance. But there’s good news: fasting may be a powerful way to combat NAFLD. Let’s explore how. 🔍 1. Reduction in Liver Fat Fasting, particularly intermittent fasting (IF), has been shown to help the liver burn stored fat. During a fasting period, the body switches to fat as a primary energy source, which helps reduce excess fat in the liver. Studies show that IF can reduce liver fat content by up to 30% in people with NAFLD. 🌟 2. Improved Insulin Sensitivity Insulin resistance is a major driver of NAFLD. High insulin levels mean more fat is synthesized and stored in the liver. Fasting helps reduce insulin levels, improve sensitivity, and reduce fat buildup in the liver, creating a healthier environment. 🚫🍬 A study published in Cell Metabolism found that alternate-day fasting improves insulin sensitivity and reduces the fat burden on the liver. 3. Lower Inflammation Levels Chronic inflammation is a key factor that turns a fatty liver into a more severe liver condition. Fasting has been shown to lower inflammation markers like TNF-α and IL-6. A report in Hepatology noted that fasting leads to a reduction in liver inflammation and oxidative stress, allowing the liver to heal more effectively. 🛡️💚 4. Weight Management & Liver Health Weight loss of even 5-10% can significantly improve NAFLD. Fasting makes weight management achievable without extreme diets, reducing calorie intake naturally while allowing the liver to reduce fat stores efficiently. ⚖️🔥 Fasting promotes a state of autophagy, where the body essentially "cleans house," breaking down damaged cells, including fat-laden liver cells, and renewing itself. Some Important Studies and Data: Journal of Clinical Investigation: Reduction in intrahepatic fat content due to intermittent fasting. Cell Metabolism: Improved insulin sensitivity through alternate-day fasting. Hepatology: Reduction in inflammatory markers and liver stress through fasting. While fasting shows promising results for managing NAFLD, it’s essential to do it safely and ideally under professional guidance. Individual health factors must be considered before adopting fasting as a lifestyle change. 💬 Have you or your clients explored fasting as a means to support liver health? What’s been your experience? Share your insights or questions below! #NAFLD #FastingBenefits #LiverHealth #Healthcare #MetabolicHealth #WeightLoss #HealthAwareness #LinkedInCommunity #IntermittentFasting #Inflammation #HealthTips

The article explores future advancements in obesity pharmacotherapy beyond GLP-1, focusing on innovative drug developments and their potential to enhance treatment effectiveness. It also discusses the implications for clinical practice and patient outcomes in managing obesity. Click here for more: https://lnkd.in/dheydbzS #obesity #pharmacotherapy #GLP1 #innovation #weightloss #healthcare #nutrition #wellbeing #treatment #medicaladvances

The article explores future advancements in obesity pharmacotherapy beyond GLP-1, focusing on innovative drug developments and their potential to enhance treatment effectiveness. It also discusses the implications for clinical practice and patient outcomes in managing obesity. Click here for more: https://lnkd.in/dCePZDeN #obesity #pharmacotherapy #GLP1 #innovation #weightloss #healthcare #nutrition #wellbeing #treatment #medicaladvances

I am excited to share this publication I co-authored. Our team explored the effects of carnitine deficiency on the efficacy of ketogenic therapy for adults with epilepsy. Our findings showed that more than 1 in 3 adults on ketogenic therapy developed carnitine deficiency while on diet therapy. More than half of those adults developed carnitine deficiency within the first 3–9 months, but hypocarnitemia may arise at any time during the course of therapy. Adults with carnitine deficiency experienced a significant increase in seizures during the 1–2-year timepoint while adults with normal carnitine levels continued to reap the benefits of ongoing seizure reduction. It may be pertinent for clinicians to check carnitine levels with other routine diet therapy lab monitoring (at 3 months, 6 months, then every 6 months) since patients are often asymptomatic, and carnitine deficiency may go undetected if it is not checked. If seizures increase on ketogenic therapy, patients may discontinue ketogenic diet therapy prematurely due to perceived lack of efficacy when the issue may be low carnitine. Other notable findings... In our retrospective analysis, 80% of adults on ketogenic therapy reported less severe seizures or complete seizure freedom at the 3-9 month timepoint, 85% at the 1-2 year timepoint, and 86% at 2+ years. Regardless of carnitine levels, ketogenic therapy may be a powerful option to reduce overall seizure severity in adults with epilepsy. #ketogenic #epilepsy #intractableepilepsy #keto #ketogenicmetabolictherapy #ketosis #modifiedAtkinsdiet

Decreases in cT1 and liver fat content reflect treatment-induced histological improvements in MASH

"New research suggests intensive lifestyle interventions are an effective way of treating and improving liver disease." “We know diet and exercise can alleviate these health conditions. Liver disease is increasing too fast. We were able to show in our research how diet and exercise should be the mainstay of treatment for the disease.” “Our findings suggest liver disease doesn’t have to be a chronic, progressive condition,” Elizabeth Parks, professor of nutrition and exercise physiology at the University of Missouri School of Medicine says. "For the first time, these results show that an improvement in peripheral (but not hepatic) insulin sensitivity and systemic markers of muscle function (i.e. cardiorespiratory fitness) were strongly related to resolution of liver disease." Original paper: Histological improvements following energy restriction and exercise: The role of insulin resistance in resolution of MASH. Mucinski, Justine M. et al. Journal of Hepatology https://lnkd.in/gDAx4J5Y American Association for the Study of Liver Diseases (AASLD), EASL | The Home of Hepatology, Canadian Association for the Study of the Liver, Global Liver Institute, LPI LIVER PATIENTS INTERNATIONAL, European Liver Patients' Association - ELPA, Global NASH Council, The Forum for Collaborative Research: Liver Forum, Barcelona Institute for Global Health (ISGlobal)

There were many studies of interest in May and, having narrowed the list down to a manageable number, it can be found on the Nutrition Network site (https://lnkd.in/d5ANv_nh)   The usual topics of NAFLD (https://lnkd.in/dfkyRtU4), type 2 diabetes (https://lnkd.in/dVSjwTuA), and metabolic health (https://lnkd.in/d-_m7tHc) are found, and yet another significant section (6 papers) that speaks to metabolic psychiatry. Each month this section appears represented; surely this rapid growth in papers and interest demands serious attention from those treating mental health conditions.   In metabolic psychiatry, there is a paper on the effect of the ketogenic diet in children with autism—specifically producing changes in the gut microbiome and inflammation status (https://lnkd.in/d-PaDgdq) and a case series demonstrating full remission of depression and anxiety utilising a ketogenic diet (https://lnkd.in/dEbBFyZ4) from Lori Calabrese, M.D. et al.   Mark Cucuzzella et al. have produced an excellent two-part work titled "The Clinical Assessment and Treatment Beyond Obesity and Overweight: The Clinical Assessment and Treatment of Excess Body Fat in Children." In part 1, insulin resistance as the root cause of pediatric obesity (https://lnkd.in/d-gtCzwK) is discussed, and in part 2, a case is made for the prescription of low-carbohydrate eating as the first approach in treatment (https://lnkd.in/d_qx-a8B).   Finally, Jeff Volek et al. cover the nutritional considerations during major weight loss therapy, with a focus on optimal protein and a low-carbohydrate dietary pattern (https://lnkd.in/dd-G6rBe). One aspect covered is suggestions for improved ketone nomenclature where hypoketonemia (often < 0.1 mM and < 0.3 mM) reflects low levels, as in the average American diet, and euketonemia (0.5 to 5.0 mM) reflects the range seen during nutritional ketosis, as experienced on a ketogenic diet, which is linked to health benefits. To differentiate between this and higher levels of ketones in the range of ketoacidosis, the designation hyperketonemia is proposed.

Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder. #Summary The gut microbiome is a heterogeneous population of #microbes comprising viruses, bacteria, fungi, and protozoa. Such a microbiome is essential for sustaining host equilibrium, and its impact on human health can be altered by a variety of factors such as external variables, social behavior, age, nutrition, and genetics. Gut microbes’ imbalances are related to a variety of chronic diseases including cancer, obesity, and digestive disorders. Globally, recent findings show that intestinal microbes have a significant role in the formation of #cardiovascular disease (CVD), which is still the primary cause of fatalities. Atherosclerosis, hypertension, diabetes, inflammation, and some inherited variables are all cardiovascular risk variables. However, studies found correlations between metabolism, intestinal flora, and dietary intake. Variations in the diversity of gut microbes and changes in their activity are thought to influence CVD etiology. Furthermore, the gut microbiota acts as an endocrine organ, producing bioactive metabolites such as #tma (trimethylamine)/TMAO (trimethylamine N-oxide), SCFA (short-chain fatty acids), and bile acids, which have a substantial impact on host wellness and disease by multiple mechanisms. The purpose of this overview is to compile current evidence highlighting the intricate links between gut microbiota, metabolites, and the development of #cvd . It focuses on how intestinal dysbiosis promotes CVD risk factors such as heart failure, hypertension, and atherosclerosis. This review explores the normal physiology of intestinal microbes and potential techniques for targeting gut bacteria for CVD treatment using various microbial metabolites. It also examines the significance of gut bacteria in disease treatment, including supplements, prebiotics, probiotics, antibiotic therapies, and fecal transplantation, which is an innovative approach to the management of CVD. As a result, gut bacteria and metabolic pathways become increasingly attractive as potential targets for CVD intervention. #microbiome #bacteria #probiotics #prebiotics #nutrition #diet #TMAO #metabolomics #metabolities #SCFA #antibiotics #Atherosclerosis, #hypertension #diabetes, #inflammation

HDL - C - the "good cholesterol" ❓ 🔥 Five things to know about the role of HDL-C: 🔴 HDL-C is essential for lipid homeostasis - it cleans out the bad cholesterol from the arteries ✅ HDL-C plays an integral role in reverse cholesterol transport by removing excess cholesterol from peripheral vessels and transporting it back to the liver for elimination. It also has important anti-inflammatory, cytoprotective, antithrombotic, antioxidative functions and many more functions. 🔴 Several factors can impair HDL-C functionality ✅ An acute-phase response (eg, to infection, inflammation, trauma) can alter plasma proteins in HDL-C, converting HDL-C from an anti-inflammatory to a proinflammatory particle. Ethnicity and dietary patterns can also affect HDL-C functionality. For example, a study found higher HDL-C antioxidant functionality and increased protection against CHD — irrespective of lower circulating HDL-C levels and higher obesity — in #BlackSouthAfrican women as compared with #White women. Regarding dietary habits, #saturated fat intake has been shown to reduce the anti-inflammatory properties of HDL-C and impair arterial endothelial function (#saturatedfat = #redmeat 🥩). 🔴 Understanding HDL-C levels can be effective in assessment of CVD risk ✅ A study reported increased risk for death in patients with #low HDL-C (< 40 mg/dL [< 1.0344 mmol/L] in men and < 50 mg/dL [< 1.293 mmol/L] in women) or #veryhigh HDL-C levels (> 80-90 mg/dL [> 2.069-2.3274 mmol/L]) compared with patients with moderate HDL-C levels. #balanceisthekey 🔑 🔴 Several factors are associated with high HDL-C levels - primarly genetic mutations of enzymes enrolled in the lipoprotein metabolism ✅ #yourgeneticsloadthegun 🔴 The focus of lipid studies has shifted to further evaluate the CV risks associated with very high HDL-C ✅ Very high HDL-C levels may result in abnormally large #dysfunctional HDL-C particles that have the potential to become trapped in the arterial intima, promoting deposition of cholesterol and increasing CVD risk. More studies need to be carried out to confirm such findings. Furthermore, most of clinical trials (HATS, AIM-HIGH, ARBITER-2, HPS2-THRIVE, CLAS, and CDP) found that #increasing HDL-C with medications had no significant impact on CV events or outcomes. #hyperlipidemia #internalmedicine #unitedarabemirates