Florida Cancer Specialists & Research Institute’s Post

🌟 Highly Cited Paper Award Winner Paper Sharing! 🌟 🔬 We are glad to share our highly cited paper titled "Allogeneic gamma delta T cells as adoptive cellular therapy for hematologic malignancies" authored by Navdeep Jhita and Sunil Raikar, belongs to the special issue "Interplay of γδ T cells and Tumor Cells". 🩸 Hematologic malignancies, given their direct tumor accessibility and less immunosuppressive microenvironment compared to solid tumors, are better suited to be targeted by cellular immunotherapies. Gamma delta (γδ) T cells, with their unique attributes spanning the entirety of the immune system, make a tantalizing therapeutic platform for cancer immunotherapy. 🔑 Keywords: Gamma delta T cells, allogeneic, immunotherapy, leukemia, chimeric antigen receptor. 🔗 This paper underscores the transformative potential of harnessing γδ T cells in the fight against hematologic malignancies. Join us in exploring the future of cancer immunotherapy! Read the full paper here: https://lnkd.in/e_AYqYvy #CancerImmunotherapy #GammaDeltaTCells #HematologicMalignancies #ResearchHighlight #Immunotherapy #ScientificAdvancements

Cancer cells often have abnormal numbers of chromosomes, or aneuploidy, which can include too many or too few copies of chromosomes. Aneuploidy can also include duplications, deletions, or duplications or deletions of entire chromosome arms. It's present in almost 90% of human cancers and often appears early in cancer development. Aneuploidy can affect the activity of thousands of genes and is associated with worse clinical outcomes and decreased overall survival in patients. Aneuploidy is caused by genomic instabilities inherent to most cancers, including chromosomal instability (CIN) and chromosome structure instability (CSI). CIN occurs when whole chromosomes are persistently lost or gained, while CSI occurs when DNA damage isn't repaired properly, leading to structural rearrangements of chromosomes. Submit your realted work in our Journal of Cancer Therapy and Research Submit your manuscript at: https://lnkd.in/gakUevWi Access our journal homepage: https://lnkd.in/dJe3Huxs For anymore queries whatsapp us at: +1 (438) 699-5365 #cancerchromosome #Aneuploidy #cancerresearch #oncology #oncologist #cancerdevelopment #chromosomeinstability #oncologist #openaccess #submissionopen #submitmanuscript

🌟 Highly Cited Paper Award Winner Paper Sharing! 🌟 🔬 We are glad to share our highly cited paper titled "Allogeneic gamma delta T cells as adoptive cellular therapy for hematologic malignancies" authored by Navdeep Jhita and Sunil Raikar, belongs to the special issue "Interplay of γδ T cells and Tumor Cells". 🩸 Hematologic malignancies, given their direct tumor accessibility and less immunosuppressive microenvironment compared to solid tumors, are better suited to be targeted by cellular immunotherapies. Gamma delta (γδ) T cells, with their unique attributes spanning the entirety of the immune system, make a tantalizing therapeutic platform for cancer immunotherapy. 🔑 Keywords: Gamma delta T cells, allogeneic, immunotherapy, leukemia, chimeric antigen receptor. 🔗 This paper underscores the transformative potential of harnessing γδ T cells in the fight against hematologic malignancies. Join us in exploring the future of cancer immunotherapy! Read the full paper here: https://lnkd.in/e_AYqYvy #CancerImmunotherapy #GammaDeltaTCells #HematologicMalignancies #ResearchHighlight #Immunotherapy #ScientificAdvancements

A Bacteria in the Mouth Might Speed Colon Cancers! Recent research suggests that a specific bacterium commonly found in the human mouth, Fusobacterium nucleatum, can travel to colon tumors and accelerate their growth. This discovery could offer new insights into combating colon cancer, a disease responsible for over 52,000 deaths annually in the United States. Researchers at the Fred Hutchinson Cancer Center in Seattle identified a particular subtype of this bacterium, known as Fna C2, which was found to be associated with colon tumors but not healthy tissue. This subtype was also more prevalent in stool samples from colon cancer patients compared to healthy individuals. The study indicates that targeting this specific bacterial subtype could lead to more effective therapies and screening methods for individuals at higher risk of aggressive colorectal cancer. Additionally, researchers suggest that microbe-based cellular therapies, using modified bacteria to deliver medicines directly to tumors, could represent a new approach to treating colon cancer. #usa #cancer #coloncancer #healthcare #health

🔬 Mitochondrial transfer in tunneling nanotubes-a new target for cancer therapy🧬 A hundred years ago, the Warburg effect unveiled a groundbreaking shift in the understanding of cancer metabolism. It showed that cancer cells predominantly rely on glycolysis for energy, even with ample oxygen, shifting from the tricarboxylic acid cycle to aerobic glycolysis. Fast forward to today, recent studies have illuminated the dynamic transfer of mitochondria within the tumor microenvironment. This transfer occurs not just between tumor cells but also involves stromal cells, immune cells, and others. In a new review, researchers delve into the pathways and mechanisms driving mitochondrial transfer within the tumor microenvironment. They explore how these activities enhance tumor aggressiveness, foster chemotherapy resistance, and facilitate immune evasion. Moreover, they discuss recent research advances and their potential clinical implications. Excitingly, targeting intercellular mitochondrial transfer emerges as a promising anti-cancer strategy. By enhancing cell-mediated immunotherapy, there is potential to pave the way for innovative treatments. This review highlights the fascinating frontier in cancer research and its future therapeutic potential, continuing to push the boundaries of science for better health outcomes. 🌟 https://lnkd.in/ggUGv_Gc #CancerResearch #WarburgEffect #MitochondrialTransfer #TumorMicroenvironment #Immunotherapy #Oncology #MedicalResearch #HealthcareInnovation

For over a century, cancer has been classified by areas of the body - lung cancer, breast cancer, etc. And yet, we see the emergence of therapies that target a specific molecular mechanism involved in cancer progression and is not necessarily tied to parts of the body. 👨⚕️🏥   Oncologists are calling for a change in the way we classify cancer. Why? Because 𝗻𝗮𝗺𝗶𝗻𝗴 𝗰𝗮𝗻𝗰𝗲𝗿 𝗮𝗰𝗰𝗼𝗿𝗱𝗶𝗻𝗴 𝘁𝗼 𝘁𝗵𝗲 𝗼𝗿𝗴𝗮𝗻 𝗶𝗻 𝘄𝗵𝗶𝗰𝗵 𝘁𝗵𝗲 𝘁𝘂𝗺𝗼𝗿 𝗼𝗿𝗶𝗴𝗶𝗻𝗮𝘁𝗲𝘀 𝗶𝘀 𝗱𝗲𝗻𝘆𝗶𝗻𝗴 𝗽𝗮𝘁𝗶𝗲𝗻𝘁𝘀 𝗮𝗰𝗰𝗲𝘀𝘀 𝘁𝗼 𝗱𝗿𝘂𝗴𝘀 𝘁𝗵𝗮𝘁 𝗰𝗼𝘂𝗹𝗱 𝗵𝗲𝗹𝗽 𝘁𝗵𝗲𝗺. A new classification could help with the development and the clinical trials of new cancer drugs, argues cancer expert Dr fabrice andre from Gustave Roussy hospital in France. It could also change the way hospitals are organized, focusing on molecular profiles instead of cancer types, and help medical education as well as the understanding patients have of their disease.   ➡️ Read all about it in the article Dr André wrote in Nature (in the first comment below) or listen to him on the Nature podcast (in the second comment below). 𝗘𝘅𝗽𝗲𝗿𝗧𝗿𝗶𝗮𝗹𝘀 𝗶𝘀 𝗿𝗲𝗮𝗱𝘆 𝗮𝗻𝗱 𝘄𝗶𝗹𝗹𝗶𝗻𝗴 𝘁𝗼 𝘂𝘀𝗲 𝘁𝗵𝗶𝘀 𝗻𝗲𝘄 𝗰𝗹𝗮𝘀𝘀𝗶𝗳𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗿𝘂𝗻 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝘁𝗿𝗶𝗮𝗹𝘀 𝗽𝗮𝘃𝗶𝗻𝗴 𝘁𝗵𝗲 𝘄𝗮𝘆 𝗳𝗼𝗿 𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁𝘀 𝘁𝗵𝗮𝘁 𝗰𝗼𝘂𝗹𝗱 𝗯𝗲𝗻𝗲𝗳𝗶𝘁 𝘁𝗵𝗼𝘂𝘀𝗮𝗻𝗱𝘀 𝗼𝗳 𝗮𝗱𝗱𝗶𝘁𝗶𝗼𝗻𝗮𝗹 𝗽𝗮𝘁𝗶𝗲𝗻𝘁𝘀.   #cancer #metastasiccancer #clinicaltrials

In the context of cancer, these proteins participate in diverse processes including angiogenesis, immune response, oxidative stress defense, and immune regulation. Understanding their roles and interactions provides insights into the complex mechanisms underlying cancer biology and can potentially inform the development of targeted therapies and treatment strategies. Featured Antibodies: CD40 Antibody - ABIN7211389 Metallothionein Antibody - ABIN7211696 NRF2 Antibody - ABIN7211413 PDGFRB Antibody - ABIN7211699 Perforin 1 Antibody - ABIN7211704 VEGF Antibody - ABIN7211348 #cancer #hallmarksofcancer #cancerresearch https://lnkd.in/gFWcX3qd

Did you know the roots of cancer immunotherapy date back to the 1890s? 🌱 Dr. William Coley, an American surgeon, created "Coley's toxins" by using a mixture of killed bacteria to stimulate the immune system to attack cancer cells. 🦠💥 Coley noticed that some cancer patients experienced tumor regression following bacterial infections. This observation led him to experiment deliberately by injecting cancer patients with Streptococcus pyogenes and Serratia marcescens. 📈✒️ He meticulously documented his results, noting that many patients showed significant tumor shrinkage and improved survival rates. 📚🩺 His groundbreaking work, although controversial and not widely accepted at the time, laid the foundation for today's advanced treatments like checkpoint inhibitors and CAR-T cell therapies. 🎗️🔬 Here's to the pioneers who paved the way for modern cancer treatment! 🙌 #CancerResearch #Immunotherapy #PreicsionOncology #MedicalHistory #Innovation #Healthcare #Oncology #ColeyToxins #MedicalPioneers #Biotech #ImmuneSystem #CAR-T #CheckpointInhibitors #Cancer

🚀 Exciting Research About Triple Negative Breast Cancer! 🚀 I recently came across a fascinating study on triple-negative breast cancer (TNBC) that reveals a critical mechanism contributing to immune evasion by cancer cells. The researchers identified a unique population of quiescent cancer cells capable of escaping T cell attacks. These cells significantly alter the tumor microenvironment, making it more hypoxic and leading to: 🔸 Increased percentage of terminally exhausted T cells. 🔸 Dysfunctional dendritic cells (DC). 🔸 Immune-suppressive features in cancer-associated fibroblasts (CAF). Moreover, the study demonstrated that the induction of HIF1a, a hypoxia marker, in TNBC xenograft models, exacerbates T cell exhaustion. This pivotal discovery suggests that combining HIF1a inhibitors with immune checkpoint therapy could revolutionize patient treatment, offering new hope for effective interventions. Check out the full study here: https://lnkd.in/e9ydgs9G #CancerResearch #TNBC #Immunotherapy #HIF1a #ClinicalImpact #ScientificDiscovery

Congratulations 💐 to Teeshyo Bhattacharya and Somasundaram Arumugam for publishing a book chapter entitled "Development of microRNA as prognostic markers in head and neck cancer" in the book "Diagnostic, Prognostic, and Therapeutic Role of MicroRNAs in Head and Neck Cancer" published by Academic press. Here the authors highlighted the role of microRNA in head and neck cancer (HNC) prognosis and how it improves the clinical management and therapy of patients with HNC. We hope this chapter will gain a wide readership among the scientific community. Book - Diagnostic, Prognostic, and Therapeutic Role of MicroRNAs in Head and Neck Cancer DOI - https://lnkd.in/gr3AP8PX #niperkpublications