Gallant Therapeutics’ Post

ACROBiosystems has unveiled its Organoid Toolbox that includes ready-to-use organoids, organoid differentiation kits, cytokines for organoid culture, and other organoid-related products. Derived from human stem cells, organoids are highly accurate tools for toxicity testing and for learning more about human health and disease. ACROBiosystems new Toolbox ads to their already wide range of organoids, including cardiac, cerebral, liver, Alzheimer’s models, and more. ACROBiosystems' Vice President of Corporate Development and Strategy, Rosanna Zhang highlighted the moral imperative to advance organoid technology to replace animals. She states “As part of the life sciences community and an upstream supplier to the biopharmaceutical industry, it's imperative that we also support the effort in reducing animal testing. This is something that we consider a social responsibility. As a leading supplier of life science solutions, the ethical concerns behind animal testing are not something that can be disregarded. Following the '3R' principle on animal experimentation – replacement, reduction, and refinement – organoids are poised to be the best available replacement to reduce our reliance on animal models in disease research." https://lnkd.in/gqMzScmx

RenBio is happy to announce the publication of a recent article in Pharmaceutics, “Enhancing In Vivo Electroporation Efficiency Through Hyaluronidase: Insights into Plasmid Distribution and Optimization Strategies." Led by Senior Research Engineer, Debnath Maji, we take a look into the promising realm of non-viral plasmid DNA delivery through intramuscular electroporation (EP) and highlight the role of hyaluronidase in enhancing transfection efficiency. Hyaluronidase has the ability to promote uniform distribution of plasmid DNA within skeletal muscle, and by leveraging bioimpedance measurements, we decipher changes induced by hyaluronidase treatment, allowing for further optimization of  EP electrical parameters. This work underscores hyaluronidase's potential in augmenting in vivo EP efficacy and offers a roadmap for tailored EP strategies. Read the full article here, https://lnkd.in/ezUETurk! 

Creative Biogene offers a comprehensive animal model efficacy assessment service, aiding in understanding the pharmacokinetics, pharmacodynamics, and therapeutic potentials of new drugs. We utilize a variety of animal models including genetically modified mice, zebrafish, and other species to accurately simulate human disease conditions. Our research focuses on evaluating drug efficacy in vivo, measuring key endpoints such as tumor growth inhibition, survival rates, and organ-specific responses. https://lnkd.in/gM5upgcy

Investigating extracellular vesicles secreted by equine adipose mesenchymal stem cells: in their latest work, Fidel Ovidio Castro at Universidad de Concepción and collaborators assessed how short-term and long-term preconditioning of equine adipose mesenchymal stem cells with TGFβ-1 affects the anti-fibrotic properties of their secreted extracellular vesicles https://lnkd.in/e2hpSiWE Their study demonstrated that preconditioning AT-MSCs with TGFβ-1 for 4 hours produces EVs with miRNA cargo potentially useful for treating fibrotic diseases like mare endometriosis. An article co-authored by Yat Sen Wong, Ana Carolina Furlanetto Mançanares, Felipe Navarrete, Pamela Poblete, Lidice Méndez Pérez, Joel Cabezas, Gonzalo Riadi and Lleretny Rodriguez-Alvarez #extracellularvesicles #exosomes #MSCs #endometrosis #miRNA #Vesiculab

Transplanting a kidney from a genetically modified pig into a man - is it a scenario straight out of a non-fiction book, or is it our reality? Really hope that Richard will be all right. #kidneytransplant #geneticengineering #healthcare #humanhealth #biotechnology #medicalresearch #medicine #organdonation

Human lifespan continues to extend as an unprecedented number of people reach their seventh and eighth decades of life, unveiling chronic conditions that affect the older adult. Age-related #skin conditions include senile purpura, seborrheic keratoses, pemphigus vulgaris, bullous pemphigoid, diabetic foot wounds and skin cancer. Current methods of drug testing prior to #clinicaltrials require the use of pre-clinical animal models, which are often unable to adequately replicate human skin response. Therefore, a reliable model for aged human skin is needed. Read More: https://lnkd.in/g8fgqaqZ #cellculture #researchers #biodiversity #Biology

I am excited to share that I recently participated in the Society of Pharmaceutical Sciences and Research #spsr. International Webinar on "Preclinical Animal provided valuable insights into the use of animal models in studying neurological diseases. The webinar also emphasized the importance of genetic models that reflect the polygenic nature of these disorders. It concluded that animal models are useful in mimicking the syndrome in its entirety and to study potential therapeutic treatment. overall, the webinar was enlightening and provided important insights into the use of preclinical animal models in studying neurological disease. #SPSR #PRECLINICALANIMALMODELS #NEUROLOGICALDISEASE #DRUGSCREENING

📚 Exciting News! 🎉 We are elated to share the publication of a book chapter on "Implantable Biosensor Platforms for Animal Model Bioassays" by Navyasree Madhu, Pamelika Das, Manoj Yellurkar, Vani Sai Prasanna, Anu Chandran, Bhavneesh Kumar, Sulagna Sarkar, Ravichandiran Velayutham, Remya Sreedhar, and Somasundaram Arumugam from the Department of Pharmacology & Toxicology. This chapter explores the role of implantable biosensors in disease tracking and precision medicine. It addresses challenges like biosensor material and size while highlighting insights from animal models like Drosophila melanogaster, Caenorhabditis elegans, Danio rerio, and Mus musculus. Congratulations to the authors on their remarkable contribution. #Pharmacology #Biosensors #AnimalModels #ResearchPublication #niperkpublications

hspGFFDMC130A line One of the key advantages of transgenic zebrafish is their suitability for high-throughput screening assays. Zebrafish embryos develop externally and are transparent, allowing for non-invasive imaging of embryonic development and organogenesis. This makes it possible to perform large-scale drug screens or genetic screens to identify compounds or genes involved in various biological processes or disease pathways.

Do pet owners in your practice want to know more about stem cell therapy? We have a handy pet owner guide on our website, which talks about the ins and outs of regenerative medicine in a way that is tailored to pet owners. This resource is completely free. Simply direct interested pet owners in your practice to the link below where they can learn more. 🔗 https://lnkd.in/edvXHnS4 #veterinarypractice #veterinaryteam #caninestemcells #equinestemcells #felinestemcells