Gazza Scott’s Post

This edited book of proceedings is a collection of seventeen selected and peer-reviewed contributions from the Virtual Conference on Chemistry and its Applications (VCCA-2022). VCCA-2022 was held online from 8th to 12th August 2022. The theme of the conference was "Resilience and Sustainable Research through Basic Sciences". 500 participants from 55 countries participated in VCCA-2022. This volume 2 reflects the chapters covering computational and industrial aspects. https://sowl.co/s/BmyN8  #chemistry #chemical #chemicalindustry #chemicalengineering #chemicals #chemicalmanufacturing #chemicalsafety #chemicalprocessing #chemicalsindustry #chemicalinnovation #biochemistry #biochemical #toxicology #sustainabledevelopment #science #physicalchemistry #researchanddevelopment #phd #scientist #experimental .

📣 For the Green Chemistry Series of Royal Society of Chemistry, the book "Sustainability in TIDES chemistry: green approaches to oligonucleotides and oligopeptides synthesis" in almost online!! 📚 This book brings together all of the information on green synthesis of oligopeptides, which is well established, and all of the preliminary data on green oligonucleotides synthesis, creating a resource that will help chemists to bridge the gap between these two areas. 🤝 It was written with the precious collaboration of leading international scientists from #academia and #industry working in the field of peptides and oligonucleotides. To mention: Markus Muttenthaler, Jan Pawlas, Jon Holbech Rasmussen, Fernando Albericio, Beatriz de laTorre, Anamika Sharma, Dr. Ashish Kumar, Ana Toplak, Piera Fonte, Alberto Oppedisano, Harrison Madge, Thomas Rupp, Antonio Ricci, Allison Wolf, Satoshi Obika, Janik Kaufmann, Marc Lemaitre, Martina Catani, Dr. Simona Felletti, Chiara De Luca, Alberto Cavazzini. 👩💼 👨💼 👩💼 We at Tolomelli-Cabri Laboratory, as book editors and authors of some chapters, will share next updates on publication process. Stay tuned!!

The book “Sustainability in ’Tides Chemistry: Green Approaches to Oligonucleotides and Oligopeptides Synthesis” is almost online! Thanks to the Editors and to all the authors 👏🏻 Our contribution is presented in Chapter 15 “Greening chromatographic purification processes”

High throughput experimentation (HTE) is frequently employed to identify reaction conditions for challenging transformations, giving access to a diverse array of medicinal chemistry targets. In parallel to using conventional batch reactions, we also incorporate flow chemistry into early phase synthesis to help with reaction selectivity and optimization, up-scaling, and solving specific chemical problems. In our upcoming webinar, case studies will be presented for both of these topics. Don’t miss your chance to ask questions to our experts! Register today by clicking 👇 #HTE #PMC #Biotech #MedChem #MedicinalChemistry #FlowChemistry #DrugDiscovery #DrugDevelopment https://lnkd.in/e_JCkhk3

Excited to announce the publication of our review article in RSC Advances. This article, titled "Exploring the latest trends in chemistry, structure, coordination, and diverse applications of 1-acyl-3-substituted thioureas: a comprehensive review" is focused on providing an overall picture of research conducted in the field of acyl thioureas in previous two years. Grateful for the support and collaboration from my co-authors and mentors. Looking forward to engaging with fellow researchers and professionals who are passionate about organic synthesis focused on biological applications. Read the full article here: https://lnkd.in/dWbNPh37 #Research #Publication #OrganicChemistry #Pharmaceuticals #ScientificCommunity

I want to share an important moment in the life of a scientist. My first publication is out: https://lnkd.in/d3tPdbtY I want to thank all the people that made this possibile! Have a look on how flow chemistry can be used to rapidly functionalize organic molecules

In an insightful segment from the webinar "Impact of Synthia on GSK Chemical Development," we explored the daily challenges that organic chemists face. Synthesizing new target molecules is a complex task, especially when additional constraints such as cost, efficiency, and safety are considered. 👩🔬 Dr. Ewa Gajewska demonstrated how SYNTHIA™ Retrosynthesis Software is transforming the laboratory by translating complex chemical knowledge into a language that computers can process. SYNTHIA™ handles multiple constraints with ease, optimizing processes that once took days into mere minutes. 💡 Imagine devising shorter, more selective synthesis routes that utilize cost-effective materials and avoid hazardous reactions—all at the click of a button. 🚀 Thanks to SYNTHIA™, what once seemed like a bottleneck in the chemical synthesis process is now a gateway to rapid, innovative solutions. This tool is not only speeding up drug development and pathway discovery as highlighted by John Jin Lim from GSK but is also setting new benchmarks in synthetic chemistry. 🔗 Watch the full webinar to witness how SYNTHIA™ is revolutionizing retrosynthesis, making it an essential ally for every chemist striving for excellence in their field. https://lnkd.in/d9QzgZVM #Chemistry #Innovation #OrganicChemistry #Synthesis #SYNTHIA #DigitalTransformation #TeamMilliporeSigma

In an insightful segment from the webinar "Impact of Synthia on GSK Chemical Development," we explored the daily challenges that organic chemists face. Synthesizing new target molecules is a complex task, especially when additional constraints such as cost, efficiency, and safety are considered. 👩🔬 Dr. Ewa Gajewska demonstrated how SYNTHIA™ Retrosynthesis Software is transforming the laboratory by translating complex chemical knowledge into a language that computers can process. SYNTHIA™ handles multiple constraints with ease, optimizing processes that once took days into mere minutes. 💡 Imagine devising shorter, more selective synthesis routes that utilize cost-effective materials and avoid hazardous reactions—all at the click of a button. 🚀 Thanks to SYNTHIA™, what once seemed like a bottleneck in the chemical synthesis process is now a gateway to rapid, innovative solutions. This tool is not only speeding up drug development and pathway discovery as highlighted by John Jin Lim from GSK but is also setting new benchmarks in synthetic chemistry. 🔗 Watch the full webinar to witness how SYNTHIA™ is revolutionizing retrosynthesis, making it an essential ally for every chemist striving for excellence in their field. https://lnkd.in/eN2zNJ4Y #Chemistry #Innovation #OrganicChemistry #Synthesis #SYNTHIA #DigitalTransformation #TeamMerck

EXPERIMENTALLY-QUANTIFICATION OH H-BOND-DONATING ABILITY OF BIOLOGICALLY RELEVANT COMPOUNDS Hydrogen bonding is a key factor in the design of ligands for biological binding, including drug targets. The Koslowski group (Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, US) has developed a method for experimentally assessing the hydrogen-bond-donating ability of an analyte using UV–vis titrations with a colorimetric sensor. Using this method, 79 new titrations were performed on weak hydrogen-bond donors, with a focus on heterocycles and pharmaceutically relevant motifs. The hydrogen-bond donating abilities of drug compounds and the substructures of drug compounds were also measured. The compounds were chosen based on recent drug approvals. These titrations will be used to build a database of hydrogen-bond donors, useful when to design ligands with optimal interactions. #H_bond_donating #MarisaCKoslowski #chemistry #medicinalchemistry https://lnkd.in/d3buixCW

In an insightful segment from the webinar "Impact of Synthia on GSK Chemical Development," we explored the daily challenges that organic chemists face. Synthesizing new target molecules is a complex task, especially when additional constraints such as cost, efficiency, and safety are considered. 👩🔬 Dr. Ewa Gajewska demonstrated how SYNTHIA™ Retrosynthesis Software is transforming the laboratory by translating complex chemical knowledge into a language that computers can process. SYNTHIA™ handles multiple constraints with ease, optimizing processes that once took days into mere minutes. 💡 Imagine devising shorter, more selective synthesis routes that utilize cost-effective materials and avoid hazardous reactions—all at the click of a button. 🚀 Thanks to SYNTHIA™, what once seemed like a bottleneck in the chemical synthesis process is now a gateway to rapid, innovative solutions. This tool is not only speeding up drug development and pathway discovery as highlighted by John Jin Lim from GSK but is also setting new benchmarks in synthetic chemistry. 🔗 Watch the full webinar to witness how SYNTHIA™ is revolutionizing retrosynthesis, making it an essential ally for every chemist striving for excellence in their field. https://lnkd.in/ePzSthmy #Chemistry #Innovation #OrganicChemistry #Synthesis #SYNTHIA #DigitalTransformation #TeamMilliporeSigma