GenEdit’s Post

The conviction that #serendipity can be, if not systematized, at least harnessed for augmented scientific discovery, has fueled my (obviously nonlinear) professional trajectory. As we saw with Fleming's "accidental" discovery of penicillin, the #AHA moment does not happen in a vacuum: the mind needs to be ready for the discovery (or "pasteurized" for chance to favor you). While researching other examples of serendipitous drug discovery, I came across an article about systematizing serendipity for cardiovascular drug discovery. It does not fully deliver on its promise, but I can't resist sharing that it is published in AHA journals. In case you are wondering, AHA is the American Heart Association. https://lnkd.in/gWhy2fUS

Ophthopedia Update:Drug Approval for the Treatment of Geographic Atrophy: How We Got Here and Where We Need to Go: To discuss the clinical trial results leading to the FDA approval of anti-complement therapies for geographic atrophy (GA), perspectives on functional data from the GA clinical trials, and how lessons from the FDA approval may guide future directions for basic and clinical research in AMD. #Ophthalmology #Ophthotwitter #Scicomm

Jayme Locke and a team of researchers at the University of Alabama at Birmingham have discovered that immunosuppressant’s that are FDA approved—and that are currently in use for human-to-human transplants—are the optimal choices for an immunosuppression regime for pig-to-human kidney transplants. To learn more about their research and what their hopes are for the future of xenotransplantation, read the full article below! #xenotransplantation #kidneytransplant

#ACROHighlights [Featured Product] 🚀 Cardiac Organoids: A New Era in Drug Safety 🫀 Ensuring drug safety is crucial, but traditional Thorough QT studies can be costly and complex. Enter cardiac organoids—a solution offering enhanced models for assessing drug effects on the heart. Our ready-to-use cardiac organoids and assay kits provide accurate, cost-effective evaluations of compounds' impact on cardiac electrophysiology. Elevate your preclinical safety data and streamline drug development with these innovative tools. 🔗 https://smpl.is/9ibwx #DrugSafety #CardiacOrganoids #BiotechInnovation #PreclinicalResearch #DrugDevelopment

🗓 On International Clinical Trials Day 🩺, we thank the patients, clinicians, researchers and partners helping to advance our pipeline of potentially lifesaving therapeutics addressing rare and life-threatening liver conditions with high unmet medical needs. #ClinicalTrialsDay #CTD2024 #InternationalClinicalTrialsDay #InnovationInHealthcare ACRP - Association of Clinical Research Professionals

💉 The Cleveland-based company designed Injectrode to treat chronic pain. The LIFE trial evaluated Injectrode’s safety and effectiveness, meeting all goals, Neuronoff, Inc. said. “The study comprised a major leap forward for the development of the Injectrode, providing valuable information that builds upon the company’s prior preclinical testing, including assessment of tolerability of sensory perception during stimulation, and first-in-human feasibility of the Injectrode’s transcutaneous stimulation approach,” Neuronoff Chief Scientific Officer Andrew Shoffstall said. 🔗 Learn more: https://lnkd.in/d7YpfqPj 📰 Follow Guided Solutions to receive the latest #MedTech news daily and subscribe to our weekly newsletter: https://lnkd.in/dht_9YcQ #MedicalDevices #MedicalDevice #MedicalEquipment #Medicine #Surgeons #GuidedSolutions

🌿 The aim of this article is to provide an up-to-date review of the existing preclinical as well as clinical studies, along with relevant systematic reviews addressing the roles of various types of #cannabinoids in neuropathic pain settings. https://lnkd.in/e9S725dz

https://lnkd.in/eTraWzWu It is important that in the context of diseases of brain including drug resistant depression, PTSD, autism, Schizophrenia we remain hopeful that one day we can cure these awful conditions using genome editing approaches which are already used in clinical trials. To do so, we need to identify key master genes which are involved in these conditions. Jamie Raskin #nih #nimh #ninds #neuralink #curebrain #mentalhealthmoonshot #chcf

Great read highlighting the business benefits of patient-centric trials (not just because we are proud to be contributing to this vital area!) We agree that prioritising patient needs leads to better outcomes, improved data quality, and ultimately, faster and more successful drug development. https://ow.ly/BGpS50T3Qx2 #PatientCare #ClinicalTrials #DrugDevelopment

𝐂𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐓𝐫𝐢𝐚𝐥 𝐑𝐨𝐮𝐧𝐝𝐮𝐩: 𝐁𝐚𝐬𝐞 𝐄𝐝𝐢𝐭𝐨𝐫𝐬 𝐢𝐧 𝐭𝐡𝐞 𝐂𝐥𝐢𝐧𝐢𝐜 🏥 There are currently four base-editing therapies being evaluated in clinical trials, and you can read about each of them in our recent clinical trial update. https://lnkd.in/ez9Md7RN 💡 You may also like our down-to-earth explainer about base editors, where you can learn about what they are, how they work, and what they are being used for. 🔔 Like getting these updates? Hit the follow button to see more of this kinda news! #crisprmedicinenews #crisprmedicine #geneediting #baseediting #crisprtrial #clinicaltrials