GTC is exhibiting at COA for the first time. Come learn about Liquid Trace that comprehensively analyzes cfDNA and cfRNA. https://lnkd.in/eEUyiVEx #COA23 #CommunityOncology #cfRNA
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➡️ This graphic is worth gold! ✅ The best guide to investigation of the hypo pharynx and larynx during EGD 📽️ Don't miss the full lecture on EndoCollab
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Professor bei Virginia Tech Carilion School of Medicine, USA; Hon. Professor, Universidad de La República; “May there never develop in me the notion that my knowledge and education are complete” (Maimonides)
➡️ This graphic is worth gold! ✅ The best guide to investigation of the hypo pharynx and larynx during EGD 📽️ Don't miss the full lecture on EndoCollab
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🎈First case with sirolimus coated balloon for In-Stent Restenosis in high calcified lesion with Geraud Souteyrand 🔎 💡 New data presented at #TCT23 : ➡️For de novo : https://lnkd.in/gCRTGXbM ➡️For ISR : https://lnkd.in/gUDAps-g ➡️ Characteristics and mechanisms of restenosis : https://lnkd.in/gUDPPUzM
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YMC Europe GmbH Guideline to optimise your IP-RP separation of oligonucleotides. 🔹 This compact guide summarises all the important aspects for the precise separation of protected and unprotected single-stranded DNA #oligonucleotides. You have a clear overview of all the essentials: 🔹 Proven strategies for high resolution and sensitivity. 🔹 Information on the selection of the appropriate ion pairing agent. 🔹 Influence of column hardware and temperature. A teaser in advance: The new bioinert-coated YMC Accura Triart C18 column is also an absolute gain for your analysis. You can check the Technical Note to unlock your full potential.
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🎯 Article#4 Small molecule induced STING degradation facilitated by the HECT ligase HERC4. Stimulator of interferon genes (STING) is a central component of the cytosolic nucleic acids sensing pathway and as such master regulator of the type I interferon response. Due to its critical role in physiology and its’ involvement in a variety of diseases, STING has been a focus for drug discovery. Targeted protein degradation (TPD) has emerged as a promising pharmacology for targeting previously considered undruggable proteins by hijacking the cellular ubiquitin proteasome system (UPS) with small molecules. Here, authors identify AK59 as a STING degrader leveraging HERC4, a HECT-domain E3 ligase. Additionally, their data reveals that AK59 is effective on the common pathological STING mutations, suggesting a potential clinical application of this mechanism. Thus, these findings introduce HERC4 to the fields of TPD and of compound-induced degradation of STING, suggesting potential therapeutic applications. Full article is available here https://lnkd.in/dRcTt_nd #drugdiscovery #smallmolecules #inhibitors #research #biotech #medicinalchemistry #drugspharmaceuticals #hitcompound #bioactivity #pharmaceuticalsciences #treatment #PROTAC #Peptidedegradation #Molecularglue #interferon #diseasetreatment #biotech #research #targets #leadgeneration
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Learn more about the methods used to quantify GPCR ligand activity (agonists, antagonists & other modulators) and the process of characterizing the mechanism of action of ligands to enable the prediction of activity in vivo systems with Dr. Terry Kenakin at the Dr.GPCR University course: Techniques for Effective Lead Optimization of Candidate Molecules 📚 ❇️Register today at https://bit.ly/4duRn9T #gpcr #drgpcr
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Vitas M Chemical Limited (mostly known under the trademark Vitas-M Laboratory) is one of the biggest suppliers of small molecule organic compounds for Drug Discovery. We have traded them for over 20 years. Our range consists of more than 1,400,000 individual molecules, ready to be selected and “cherry picked” by you. Today, I'm starting a series of scientific articles where researchers share their groundbreaking results - all achieved with the help of small molecules available from Vitas M. These powerful molecules have unlocked new possibilities in the quest for innovative therapeutics. Whether you're working on cancer treatments, neurological disorders, or any other critical area of research, Vitas M's diverse compound collection can be your gateway to scientific breakthroughs. Discover our powerful small molecule collection! 🎯 Article# 1. Discovery of a fragment hit compound targeting D-Ala:D-Ala ligase of bacterial peptidoglycan biosynthesis. Bacterial resistance is an increasing threat to healthcare systems, highlighting the need for discovering new antibacterial agents. An established technique, fragment-based drug discovery, was used to target a bacterial enzyme Ddl involved in the biosynthesis of peptidoglycan. We assembled general and focused fragment libraries that were screened in a biochemical inhibition assay. Screening revealed a new fragment- hit inhibitor of DdlB with a Ki value of 20.7 ± 4.5 mM. Binding to the enzyme was confirmed by an orthogonal biophysical method, surface plasmon resonance, making the hit a promising starting point for fragment development. Full article is available here https://lnkd.in/dNyCng3h #drugdiscovery #smallmolecules #inhibitors #research #biotech #medicinalchemistry #drugspharmaceuticals #hitcompound #bioactivity #pharmaceuticalsciences #treatment #diseasetreatment #biotech #research #targets #leadgeneration #Fragmentbaseddrugdiscovey #FBDD #covalentfragments #bacterial
June_26_2024.pdf
drive.google.com
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Simple and practical
Simplicity is the ultimate sophistication. Biolayer Interferometry is simple and sophisticated. It is the fundamental reason that BLI took off in the bioanalytical world.
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What BCID panels does your lab use? Utilizing ZeptoMetrix NATtrol controls on a consistent basis helps monitor test performance and provides additional confidence in the quality and reliability of your lab operations. Order the panels you need now to continue providing accurate results tomorrow. Get started! https://lnkd.in/gMQ-st6g #BloodstreamInfections #MolecularControls #ClinicalLabs #QualityControls #BCID #BCIDpanel
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