Halozyme, Inc.’s Post

Salt-tolerant #endonucleases and the benefits for #viralvectormanufacturing, and a comparison of two marketed #enzymes Host cell nucleic acid removal with endonucleases is an important step in #viralvector manufacturing processes. To further improve the production efficacy of viral vectors, higher salt concentrations can be applied, but as a result, this may inhibit the function of endonucleases, which causes challenges. This month, join c-LEcta GmbH’s Marc Struhalla (CEO) and Svenja Michalek (Product Manager Biopharma) as they introduce a novel engineered variant of the Serratia marcescens wild-type enzyme, which is more tolerant to higher salt concentrations and can streamline the viral #vectormanufacturing process. Data generated by a cell and #genetherapy #CDMO who compared DENARASE® High Salt with another commercially available salt-tolerant endonuclease (SAN HQ) in an AAV2 harvest will be presented Register for this upcoming #webinar below:

Salt-tolerant #endonucleases and the benefits for #viralvectormanufacturing, and a comparison of two marketed #enzymes Host cell nucleic acid removal with endonucleases is an important step in #viralvector manufacturing processes. To further improve the production efficacy of viral vectors, higher salt concentrations can be applied, but as a result, this may inhibit the function of endonucleases, which causes challenges. This month, join c-LEcta GmbH’s Marc Struhalla (CEO) and Svenja Michalek (Product Manager Biopharma) as they introduce a novel engineered variant of the Serratia marcescens wild-type enzyme, which is more tolerant to higher salt concentrations and can streamline the viral #vectormanufacturing process. Data generated by a cell and #genetherapy #CDMO who compared DENARASE® High Salt with another commercially available salt-tolerant endonuclease (SAN HQ) in an AAV2 harvest will be presented Register for this upcoming #webinar below:

How can intestinal organoids be used in #DrugDiscovery? Find out what these organoids are, how they replicate the human gut, and ways they can be used in drug screening in this upcoming webinar with STEMCELL Technologies! Learn more & register here ⏩ https://bit.ly/49wvFAA #DrugDevelopment #GutBiome

We’ll be at #BPI2024 showcasing our newly launched Atlas system for rapid, on-demand, at-line analysis throughout the bioprocess. Stop by to learn how you can get data for excipients, surfactants, high-concentration proteins and monoclonal antibodies simultaneously in 1-minute. #bostonbiotechweek #bioprocessing #bioprocessinginternational https://lnkd.in/gQaFwry2

Bioanalysis of immunogenicity is critical for the development of therapeutic proteins. Explore how immunogenicity can affect both the safety and efficacy of biological drugs in this infographic, part of our #Spotlight created in association with ICON plc >>> https://hubs.ly/Q02PvBph0

Introducing our Enhanced UGT Phenotyping Assay!   Another portfolio update resulting from our continuous internal R&D!   We're thrilled to introduce our improved UGT phenotyping assay. By incubating the study compound and UGT-specific model substrates in parallel with both HLM and recombinant enzymes, we unlock the ability to calculate RAFs for each UGT isoform. This quantitative approach empowers a more comprehensive assessment of the major hepatic UGTs involved in metabolizing the compound.   The insights garnered from this assay provide invaluable support in evaluating the risk of drug-drug interactions, ultimately contributing to informed decision-making in drug development.   Stay tuned for more updates and contact us to discuss more! https://lnkd.in/d8P8S99G https://lnkd.in/g2skidYU Admescope a Symeres company #Admescope #Symeres #UGTphenotyping #drugmetabolism #drugdiscovery #drugdevelopment #ADMEtox

In this webinar, ExcellGene SA will discuss a rapid and routine method for the assessment of titers and quality of AAV viral particles at various stages in bioprocessing. Emphasizing the critical role of easy assay development. Register now: https://ow.ly/htNf50Qsu4R #OctetBLI #AdenoAssociatedVirus #GeneTherapy #ViralVectors #bioprocesssing #biopharma #free #webinar #AAV SelectScience®

https://lnkd.in/gEeXSP6f come join us this Wednesday for a dive into the use of human intestinal organoids in drug discovery

It’s all about the antibody glycan. Following millions of years of evolution, the native glycan was retained in a similar position on all antibodies and GlycoConnect™ is built entirely around this. GlycoConnect™ matches payload potency with the most appropriate drug-antibody ratio (DAR), enabling best-in-class therapeutic efficacy and tolerability. Any antibody can be converted into a stably conjugated #ADC in just a few days by modifying the native #antibody #glycan using our highly efficient enzymes and metal-free #clickchemistry approach. Visit our website linked below to learn more about GlycoConnect™. #drugdevelopment #ADCs #biotech

ESTROM WIDAL KIT This reagent is used for the detection of specific antibodies produced in serum as a result of stimulation by a specific antigen of Salmonella(group). For more info- https://lnkd.in/g3srMbGH #widalkit #kit #detection #antibodies #serum #antigen #salmonella #angstrom #biotech #manufacturing #manufacturer #manufacturingindustry #medicaldevices #medicaldevice