Halozyme, Inc.’s Post

How can intestinal organoids be used in #DrugDiscovery? Find out what these organoids are, how they replicate the human gut, and ways they can be used in drug screening in this upcoming webinar with STEMCELL Technologies! Learn more & register here ⏩ https://bit.ly/49wvFAA #DrugDevelopment #GutBiome

Salt-tolerant #endonucleases and the benefits for #viralvectormanufacturing, and a comparison of two marketed #enzymes Host cell nucleic acid removal with endonucleases is an important step in #viralvector manufacturing processes. To further improve the production efficacy of viral vectors, higher salt concentrations can be applied, but as a result, this may inhibit the function of endonucleases, which causes challenges. This month, join c-LEcta GmbH’s Marc Struhalla (CEO) and Svenja Michalek (Product Manager Biopharma) as they introduce a novel engineered variant of the Serratia marcescens wild-type enzyme, which is more tolerant to higher salt concentrations and can streamline the viral #vectormanufacturing process. Data generated by a cell and #genetherapy #CDMO who compared DENARASE® High Salt with another commercially available salt-tolerant endonuclease (SAN HQ) in an AAV2 harvest will be presented Register for this upcoming #webinar below:

We’ll be at #BPI2024 showcasing our newly launched Atlas system for rapid, on-demand, at-line analysis throughout the bioprocess. Stop by to learn how you can get data for excipients, surfactants, high-concentration proteins and monoclonal antibodies simultaneously in 1-minute. #bostonbiotechweek #bioprocessing #bioprocessinginternational https://lnkd.in/gQaFwry2

⚗️ Defining Purity within the RNA By Design™ approach. DRUG SUBSTANCE - the A260/A280 ratio The A260/A280 ratio is crucial for assessing the purity of RNA-based products. This ratio measures the absorbance of ultraviolet light at 260 nm and 280 nm, with a value around 2.0 generally indicating pure RNA. Deviations from this value can signal contamination by proteins, phenol, or other substances, which can interfere with RNA function. Such contaminants may lead to inaccurate diagnostic results, reduced therapeutic effectiveness, unwanted immune responses, or compromised RNA stability and integrity, ultimately affecting the product’s safety and efficacy. At #Centillion Technology, we optimise our processes to maintain an ideal A260/A280 ratio, ensuring the purity, safety and efficacy of the RNA-based products manufactured on our #BiaB™ technology platform. #RNAbyDesign #PurityCQA #Quality #Compliance

Salt-tolerant #endonucleases and the benefits for #viralvectormanufacturing, and a comparison of two marketed #enzymes Host cell nucleic acid removal with endonucleases is an important step in #viralvector manufacturing processes. To further improve the production efficacy of viral vectors, higher salt concentrations can be applied, but as a result, this may inhibit the function of endonucleases, which causes challenges. This month, join c-LEcta GmbH’s Marc Struhalla (CEO) and Svenja Michalek (Product Manager Biopharma) as they introduce a novel engineered variant of the Serratia marcescens wild-type enzyme, which is more tolerant to higher salt concentrations and can streamline the viral #vectormanufacturing process. Data generated by a cell and #genetherapy #CDMO who compared DENARASE® High Salt with another commercially available salt-tolerant endonuclease (SAN HQ) in an AAV2 harvest will be presented Register for this upcoming #webinar below:

In this webinar, ExcellGene SA will discuss a rapid and routine method for the assessment of titers and quality of AAV viral particles at various stages in bioprocessing. Emphasizing the critical role of easy assay development. Register now: https://ow.ly/htNf50Qsu4R #OctetBLI #AdenoAssociatedVirus #GeneTherapy #ViralVectors #bioprocesssing #biopharma #free #webinar #AAV SelectScience®

🧪 Dr. Bonnie Blazer-Yost has a potential #hydrocephalus drug treatment in the pipeline. Hear about how she first discovered this drug, and what steps she took to test its effectiveness in animal models. Have you wondered why it takes so long to develop new drugs, and why so many fail? Learn more about the realistic timeline of drug development. Register today at https://lnkd.in/eaWT8TU4!

Praesidia’s Linker Enzyme Substrate System (LESS™) technology can significantly increase the Therapeutic Index of a drug. Our #MOA video demonstrates how. #Transporters #ChangeMedicine #BBB #TissueTargeting

Host cell proteins (HCPs) pose challenges in therapeutic protein manufacturing due to their potential immunogenicity and degradation of drug substances. Our latest article reviews the important methods for HCP detection, such as ELISA and LC-MS, and discusses their strengths and limitations. Discover how employing complementary techniques can help mitigate the risks associated with HCP contamination and enhance biomanufacturing processes. #HCPs #Biomanufacturing #ProteinTherapeutics https://lnkd.in/gd4hJJSw

Want to improve your vetinary vaccine production? Use BSA Max+, a lipid rich natural growth component that specifically aid in the growth of difficult organisms such as Leptospira and Borrelia. Find out more at www.NEWLIFEBIOLOGICS.com #NLB #BSA #vaccineproduction