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📢 Join Our Upcoming Webinar! 🚀 🔬 Titre : New Advances in Extracellular Vesicle miRNA Research Using High-Throughput Affinity Capture 🗓️ When: Wednesday, February 28th at 20:00 🔍 About: 🔍Extracellular vesicles (EVs) are a diverse group of membrane-bound particles ranging from approximately 30nm up to a few micrometers in diameter. The development of accurate and reliable EV-based diagnostics necessitates the identification of disease-associated biomarkers within specific EV subpopulations and the implementation of rapid, reproducible and scalable sample processing. Conventional isolation methods face challenges due to the co-isolation of particles with similar physicochemical properties. Promising alternatives involve methods targeting specific vesicle-surface epitopes, compatible with automated platforms. Join our featured speaker, Dr. Greg Rice from INOVIQ, as he identifies challenges associated with translating our understanding of extracellular vesicle biology into clinically useful applications and to highlight potential solutions. 🎙️ Présenté par :Dr. Greg Rice, INOVIQ 👉 Inscrivez-vous maintenant afin de le visionner à la demande https://lnkd.in/g-8PMzze

The latest developments of #OATD02 from #Molecure's collaboration with Prof. Dr. Carsten Hopf and Dr. Yasemin Ucal from the Center for Mass Spectrometry and Optical Spectroscopy (CeMOS) at the Mannheim University of Applied Sciences 👩🔬   With advanced MALDI-MSI technology provided by EU-OPENSCREEN, we visualized metabolic alterations induced by OATD-02, revealing increased arginine levels and decreased polyamine levels in tumors. The conclusion was that the metabolic activity of OATD-02 demonstrates significant changes in tissue distribution of important metabolic biomarkers confirming intracellular inhibition of ARG2 activity explaining anti-cancer effects 💊   The next phase of our collaborative journey entails disseminating the scientific findings, compiling, and publishing results in a peer-reviewed paper. Our aim is to contribute valuable insights to the broader scientific community and potentially impact future research and applications in the field 🤝   Find out more here: https://lnkd.in/dvP5f3KB

Exciting times at the XLIX Annual Meeting of the Portuguese Society for Immunology in Porto! Over the past two days, Fátima Castro Ferreira and Vítor Hugo Gonçalves proudly represented NZYtech, showcasing our cutting-edge solutions in molecular biology at the Fundação Eng. António de Almeida at an event organized by SPI Sociedade Portuguesa de Imunologia. It was a privilege to engage with fellow experts and enthusiasts in the field, exchanging insights and fostering collaborations. Events like these not only highlight our commitment to innovation but also reinforce our dedication to advancing scientific research. #molecularbiology #research #lifesciences

AlveoGene’s Mission is to transform respiratory disease outcomes using inhaled gene therapy.     Our #InGenuiTy® platform enables us to deliver our proprietary self-inactivating lentiviral vector based products directly to the lung via nebulisation treating disease locally, efficiently, and safely where it’s clinical impact and patient benefit can be the greatest. We focus on respiratory diseases of high value and unmet medical need, developing first-in-class and best-in-class products including Alpha-1 Antitrypsin Deficiency (AATD), Neonatal Profound Surfactant Protein Deficiencies (SP-B and ABCA3), and Idiopathic pulmonary Fibrosis (IPF). Ahead of Rare Disease Day this Thursday, please join the Oxford-Harrington 2024 Rare Disease Day Webinar hosted on Wednesday, Feb. 28, 2024, from 10:00 – 11:00 a.m. EST/3:00 p.m. to 4:00 p.m. GMT by clicking the link below. @HarringtonDI_UH @OHRareDisease

In this episode of the Life Science Success Podcast, 🌟 Meet Thomas Rademacher, MD, PhD: A Trailblazer in the Intersection of Science and Entrepreneurship 🌟 Pioneering Leadership: As the co-founder and CEO of Emergex, Dr. Rademacher exemplifies the fusion of deep scientific knowledge with visionary leadership, steering the company towards innovative healthcare solutions. Academic Excellence: With a rich academic background, including an Emeritus Professorship of Molecular Medicine at the University College of London, his journey from hardcore biochemistry PhD studies at the University of Wisconsin Madison has set a solid foundation for his groundbreaking work. Innovation in Monoclonal Antibodies: Dr. Rademacher's significant contributions to monoclonal antibody research, particularly using Chinese hamster ovary (CHO) cells, have paved the way for advancements in modern medicine and biotechnology. Entrepreneurial Spirit: His entrepreneurial ventures, notably including the Glycobiology Institute, highlight his ability to translate scientific research into successful business endeavors, attracting interest from major corporations. Forward-Thinking in Immunology and Vaccinology: Currently focused on developing next-generation vaccines that activate the cellular immune response, Dr. Rademacher's work involves cutting-edge technologies like quantum-confined gold clusters and micro-needle delivery systems. Dr. Thomas Rademacher embodies the spirit of innovation, seamlessly blending research and entrepreneurship to tackle some of the most pressing challenges in healthcare today. Follow his journey as he continues to make significant strides in science and industry. #HealthcareInnovation #Biotechnology #Leadership #MonoclonalAntibodies #Vaccinology https://lnkd.in/gCfaMrFB

Join our webinar to discover how Professor Haico van Attikum and his team from Leiden University Medical Center are using Twist Bioscience Site Saturation Variant Libraries to characterize the functional impact of PALB2 variants. In this webinar, you will: - Discover the importance of systematically assaying the functional impact of missense variants in clinically relevant genes - Hear how Leiden University Medical Center developed a high-throughput assay to interrogate variants in PALB2 - Find out why Twist SSVL was chosen to power this research - Learn the significance of these findings in categorizing PALB2 missense VUS and guiding the clinical care of carriers Don’t forget to register! https://lnkd.in/d7CW4QbU

Join our webinar to discover how Professor Haico van Attikum and his team from Leiden University Medical Center are using Twist Bioscience Site Saturation Variant Libraries to characterize the functional impact of PALB2 variants. In this webinar, you will: - Discover the importance of systematically assaying the functional impact of missense variants in clinically relevant genes - Hear how Leiden University Medical Center developed a high-throughput assay to interrogate variants in PALB2 - Find out why Twist SSVL was chosen to power this research - Learn the significance of these findings in categorizing PALB2 missense VUS and guiding the clinical care of carriers Don’t forget to register! https://lnkd.in/d7CW4QbU

This year has presented me with many challenges, and solving them required a great deal of my time, energy, and even health. But now that I am looking back, I can say I am proud of the results that I have accomplished at Translational Omics Group (led by Prof. Janis Klovins, Ph.D.) together with my talented colleagues.👩🔬 Here are some of the results that I want to remember from 2023: 1️⃣ I was leading the development of participant application, sample, and document logistics system that led to the launch of the Latvian Genome Reference project (part of the European '1+ Million Genomes' Initiative). 🧬 2️⃣ We successfully finished the INTEGROMED project (funded by the Horizon2020 program) that I have been coordinating since 2019, and I had the great opportunity to visit the University of Dundee and Weizmann Institute of Science for knowledge exchange. 3️⃣ Together with Justīne Puriņa, we set up the first in vitro anaerobic cultivation system for gut microbiota extracted from the human stool at Latvian Biomedical Research & Study centre, and the first experiments have yielded promising results and opened doors for new collaborations. 🦠 4️⃣ I have gathered multi-omics (blood metabolomics, blood transcriptomic, and urine metabolomics) data of COVID-19 patients during the POST-COVID-TRACK project (funded by the European Regional Development Fund), and I am in the process of publishing the results. Another accomplishment to mention is the finished online course in pharmacology facilitated by HMX – Harvard Medical School that I took from September 5, 2023, to November 17, 2023. And even though the course was not easy, it was humbling to be reminded of the old truth once again - the more I learn, the more I realize, the less I know. Cheers to more challenges and solutions in 2024 🥂

The highly anticipated Biophysical Society Annual Meeting BPS2024 is just around the corner, and the excitement is palpable! From February 10th to February 14th, the scientific community will converge in beautiful Philadelphia, Pennsylvania, for an event that promises to be truly exceptional.( https://lnkd.in/gzzqSVrz ). BPS2024 is gearing up to offer a remarkable lineup of symposia and workshops, delving into the latest cutting-edge technologies shaping the landscape of biophysics. At Helix, we're thrilled to be a part of this incredible gathering. You can find us at Booth 918, and we extend a warm invitation for you to drop by and chat with us. Our recent move to an impressive new facility marks an exciting chapter in our journey, allowing us to continue expanding our services, including protein/antibody crystallization, Cryo-EM, gene expression analysis, and much more! Whether you want to discuss your project, seek advice, or simply engage in stimulating conversations, we're here for it all!   Did you know... Helix takes pride in offering crystallography and structure determination services incorporating the latest laboratory technology, exceptional scientific expertise, and advanced computational software? We are passionate about delivering world-class results of the highest quality to our valued clients. When you choose Helix, you can expect nothing less than excellence. Don't wait any longer - give us a call, and let us exceed your expectations!   #cryoem #crystallization #crystallography #drugdiscovery #drugdesign #protein #proteins #dna #rna #antibody #antibodies #science #nature #research #bio #bionetwork #biotechnology #biotech #bioscience #biotechnologyindustry #biopharma #drugdesign #drugdevelopment #pharmaceuticals #pharma #drug #lifesciences #lifescience

Join our webinar to discover how Professor Haico van Attikum and his team from Leiden University Medical Center are using Twist Bioscience Site Saturation Variant Libraries to characterize the functional impact of PALB2 variants. In this webinar, you will: - Discover the importance of systematically assaying the functional impact of missense variants in clinically relevant genes - Hear how Leiden University Medical Center developed a high-throughput assay to interrogate variants in PALB2 - Find out why Twist SSVL was chosen to power this research - Learn the significance of these findings in categorizing PALB2 missense VUS and guiding the clinical care of carriers Don’t forget to register! https://lnkd.in/d7CW4QbU