HDAX Therapeutics’ Post

Connect With the Leaders in Structural Cell Biology in the Nervous System | March 19 Emerging research indicates that intrinsically disordered proteins impact neuronal cell function and the landscape of neurological disease. This meeting brings together cell scientists and neuroscientists to foster a global discussion on the structure of subcellular compartments like synapses and the potential functional impacts of protein aggregates and liquid condensates in neuronal cells. Speakers • Pietro De Camilli, Yale University • Shigeki Watanabe, Johns Hopkins University • Mingjie Zhang, Southern University of Science and Technology (China) Learn more and reserve your spot: https://ow.ly/YwY350Qua43

I recently had the opportunity to represent AmberGen and present a poster at the American Society For Mass Spectrometry (ASMS) annual meeting this month. The poster reports a workflow we call 'Cyclic MALDI-IHC’. AmberGen’s Miralys™ MALDI-HiPlex-IHC is used to simultaneously image hundreds of intact proteins on a tissue section, tissue microarray, or single cells. The Cyclic MALDI-IHC workflow consists of reusing the same tissue section for successive imaging: (i) with the same panel of probes resulting in nearly identical images across cycles demonstrating this is a non-destructive workflow; (ii) with the same panel of probes at higher spatial resolution to image specific regions of interest; (iii) or image even with a completely different panel of probes to obtain additional biological information from precious samples. While this poster demonstrates successive cycles of MALDI-IHC, it also opens the doors for other multiomic and multimodal workflows (e.g., lipids, small molecules, drugs, transcripts) on the same tissue section. If you would like to learn more, contact us at AmberGen.com (info@ambergen.com). I am very grateful for the guidance of the scientific team at AmberGen including Prof. Kenneth Rothschild, Dr. Mark Lim, and Dr. Gargey Yagnik as well as our CEO, John Gillespie!   #ASMS #MSI #spatialbiology #neuroscience #multiomic #multimodal #proteomics

I am grateful to share my results at the 8th Myology Congress in Paris on combined therapy between antisense oligonucleotides and Histone deacetylase inhibitors to improve dystrophin rescue in Duchenne Muscular Dystrophy. International Congress of Myology AFM-Téléthon

As a researcher in the field of microRNAs for many years now, I cannot be more than thrilled that the 2024 Nobel Prize in Physiology or Medicine has been awarded to two giants in the field of microRNA science, Prof. Victor Ambros and Prof. Gary Ruvkun who discovered "microRNA, a new class of tiny RNA molecules that play a crucial role in gene regulation"!!! Thanks to their discoveries, my laboratory and others around the world are studying these molecules that are crucial in the progression of lung cancer and offer unprecedented opportunities to predict response to cancer immunotherapies and new therapeutic strategies! #microRNA #NobelPrize2024 #LungCancer https://lnkd.in/dGHdNMB7

Most of the people know my work in neuroscience but I did also work on muscle development during my PhD and had got intriguing results, although unpublished. Here we wrote a book chapter on cellular and mechanisms of muscular dystrophy. Those interested in the field, have a glance!

The Radiobiology-Biophysics Lab is very happy to launch its Linkedin account with a picture of our wonderful team enjoying a summer lunch together before the holidays 🌞 Our areas of research focus on the mitochondria, and mainly on two aspects: - ☢ The mitochondrial response following X-irradiation after treatment of human cells with radioprotective or radiosensitizing compounds. - 🔬 The maintenance of mitochondrial DNA using biophysical approaches allowing the study of DNA-protein interactions at the single-molecule level.

🚀 Excited to share that my research article, titled "Design, Synthesis, Evaluation, and Molecular Docking Study of Novel Quinoline Hydrazone Analogues as Anti-Tubercular Agents," has been published in the Journal of Computational Biophysics and Chemistry! 🌟 This work, derived from my MS thesis at NIPER Raebareli, explores novel approaches to combating drug-resistant tuberculosis through innovative molecular design and synthesis. I would like to thank my mentor Dr. Gopal Khatik sir, and other co-authors for their constant support and motivation.! 🙌 DOI: https://lnkd.in/gf6eUaaf #Research #PharmaceuticalSciences #DrugDiscovery #Tuberculosis #NIPER

I'm thrilled to share that my doctoral thesis work has been published! 🎉 💃 "KIS counteracts PTBP2 and regulates alternative exon usage in neurons"   https://lnkd.in/dPf-adNB In this paper we reveal how KIS(S 🤘 ), the only kinase with a unique protein-protein binding domain found in spliceosome proteins, can phosphorylate the master regulator of neuronal fate: PTBP2. This modification disrupts its interactions with other proteins (MATR3 and hnRNPM) and pre-mRNA, impeding the regulation of alternative splicing. Our research highlights a novel post-translational regulation of splicing regulators, bridging the gap between transcriptional and alternative exon usage pathways in neuronal development. This work opens new avenues for understanding the molecular intricacies of neuron differentiation.

Excited to share our preprint! We delve into the ways that a mouse embryo breaks symmetry and specifies cell fates for the first time. It turns out that cells polarize asynchronously at the 8-cell stage, and this has implications for lineage allocation: https://lnkd.in/efYxvwpt This culminates much of my PhD work under the supervision of Magdalena Zernicka-Goetz, and the work of my postdoc mentor and co-first author Meng Zhu. It was only made possible by the contributions of so many talented people (special note for lab manager Maciej Meglicki). An amazing journey! Our paper attempts to link different ideas into one model for the first cell fate decision, although unanswered questions still remain! This is a topic of long-standing interest in the MZG lab, and you can read our review on the field here: https://lnkd.in/e4TsrHjy

🎉 Celebrating the Nobel Prize in Physiology or Medicine 2024! 🎉 Congratulations to Victor Ambros and Gary Ruvkun, this year’s Nobel Laureates, for their pioneering discovery of microRNAs—tiny but powerful molecules that regulate gene expression and have reshaped our understanding of biology, aging, cancer, and development. At TAmiRNA GmbH, we’ve been deeply inspired by this breakthrough and have dedicated over 10 years to harnessing the potential of microRNAs. We’ve developed cutting-edge diagnostic tools that leverage microRNAs as biomarkers, with our regulatory approved hepatomiR® device leading the way in improving liver cancer patient care across Europe. Our passion for innovation has resulted in over 100 scientific publications, and we’re proud to contribute to advancing this transformative field. The Nobel Prize serves as a reminder of the impact that these discoveries can have on medical technologies, and we’re committed to pushing the boundaries further—developing novel diagnostic and therapeutic solutions based on this incredible science. 🔬 Let’s continue to drive innovation in healthcare together! #NobelPrize #microRNA #Innovation #TAmiRNA #MedicalTechnology #Biotech #CancerResearch #LiverCancer #Diagnostics