HMRI - Huntington Medical Research Institutes’ Post

I'm thrilled to share that my paper, "Longitudinal Relationship Between Brain Atrophy Patterns, Cognitive Decline, and Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease Explored by Orthonormal Projective Non-Negative Matrix Factorization", has been published in the Journal of Alzheimer's Disease. In this study, we applied a refined version of orthonormal projective non-negative matrix factorization (OPNMF) to identify 6 distinct spatial components of voxel-wise volume loss in the brains of 83 Alzheimer’s disease subjects. We then examined how these patterns correlate with cognitive decline and cerebrospinal fluid (CSF) biomarkers both cross-sectionally and longitudinally. This publication is particularly special to me as it's my very first publication as a first author. I am deeply thankful for my team's support and collaboration. This is a significant milestone in my journey in biomedical research, and I am eager to continue pursuing this passion throughout my PhD. Link to the paper: https://lnkd.in/g-iaHFCt.

ICYMI: Watch the AGBT Morning Buzz with Joe B. alongside esteemed panelists Miranda Orr, PhD, Arutha Kulasinghe, PhD, and Holger Heyn, PhD for an entertaining round table discussion. 🌟 Explore the cutting-edge trends shaping spatial biology and unlock the potential of plex technology. 🔍 How does spatial biology revolutionize research in cancer, COVID, and neuroscience? Tune in to discover the impact firsthand! 🔬 Learn about the seamless integration of GeoMx DSP and CosMx SMI across workflows, and how spatial multiomics accelerates groundbreaking discoveries. Don't miss out on this insightful conversation! Click the link below to watch now: https://bit.ly/49OOted #SpatialBiology #AGBT2024 #MustWatch This post may include information regarding CosMx™ SMI products for RNA detection, which products are not available in the Federal Republic of Germany, as further described here - https://lnkd.in/gUXh88Pr.

Pathologies such as cancer and premature aging have long puzzled researchers. However, the complexity of shelterin, coupled with its structural variability, has posed a significant challenge in characterization using high-resolution techniques like cryo-EM. John Zinder, PhD, and his colleagues from The Rockefeller University have managed to circumvent this challenge, by reconstituting the shelterin complex and studying its composition and structural heterogeneity with mass photometry, structural modeling, negative stain EM and mass spectrometry. We had the chance to speak with John about his findings and the important role that mass photometry played in his research, orthogonally to other bioanalytical techniques. To read the blog click the following link ➡ https://lnkd.in/d84MspcH

Preprint alert!! Glad to share that parts of the final chapter of my PhD work have taken the shape of a paper. In collaboration with David Somers, Yakeel T. Quiroz, PhD and the amazing COLBOS initiative where a Colombian family was studied who had the prevalence of a gene called Presenellin 1 (PSEN1) which makes the carriers nearly 100% likely to develop Alzheimer's disease. Yakeel and her colleagues have studied this cohort for a long time and found remarkable differences in how Alzheimer's starts to develop over time. In this paper, we looked at PSEN1 carriers (n=32) and matched controls (n=35) and found that we can create predictive models of tau and amyloid-beta concentrations in the carriers using their functional connectivity data estimated using fMRI. The models trained on tau from different brain regions and word recall cognitive scores were strongly predictive whereas those trained on amyloid-beta were weakly predictive. We were able to find specific connectivity between temporal cortex, default network and dorsal attention network as strongly predictive of tau/amyloid/cognitive values. We hope this project will help us develop a functional connectivity based biomarker of Autosomal Dominant Alzheimer's and can help aid in the early diagnosis as fMRI is more available than PET and could help clinicians and patients. Link to the paper: https://lnkd.in/dHJT4D3D

📢 𝐓𝐡𝐞 𝐛𝐢𝐫𝐭𝐡 𝐨𝐟 𝐗-𝐫𝐚𝐲 𝐚𝐧𝐝 𝐚 𝐧𝐨𝐛𝐥𝐞 𝐠𝐞𝐬𝐭𝐮𝐫𝐞 💬 Wilhelm Conrad Röntgen, a German physicist, earned the first Nobel Prize for Physics in 1901 for his groundbreaking discovery of X-rays, which revolutionised both modern physics and diagnostic medicine. On November 8, 1895, during his extensive studies, he observed that cathode rays produced a mysterious radiation, capable of penetrating various materials and thicknesses. He called it an X-ray. In early 1896, X-rays began to be used in various treatments, including cancer therapy. Although the method of treatment using X-ray is not patentable, the equipment involved in generating X-ray is eligible for a patent. However, despite his significant contribution, Röntgen chose not to patent his discovery, believing it should benefit humanity. His noble gesture marked an incredible development in human medicine, saving millions of lives. Join us every Friday for more fascinating IP facts! What other examples of noble gestures in science can you think of? 𝐒𝐨𝐮𝐫𝐜𝐞: https://lnkd.in/e5ePN8k #FunFactforFriday #IntellectualProperty #SouthEastAsia

Our next speaker, Dragomir Milovanovic is fascinated by how thousands of macromolecules and organelles self-organize at the synaptic buttons, the critical communication sites between neurons. Since January 2020, he has led the Laboratory of Molecular Neuroscience within the German Center for Neurodegenerative Diseases (DZNE). Drago pioneered the concept of liquid-liquid phase separation at the synapse, demonstrating that synaptic vesicles can organize into a distinct liquid phase, akin to oil droplets in water (Milovanovic et al., Science 2018, Hoffmann et al., Nat Comm 2023). The work from his lab showed that the condensates of synaptic vesicles act as a buffer recruiting disordered synaptic proteins such as alpha-synuclein, a protein implicated in the pathology of Parkinson’s Disease. Recently, the lab discovered that condensates can harbor electric potential at their interfaces, suggesting a new function of condensates as mesoscale capacitors that can store charge. Condensate biology is now emerging as a key mechanism for understanding synapse organization (Sansevrino et al., Trends Neursci, 2023) #Horizons2024 #synaptology #phaseseparation

Experience a different approach to learning #biology with animations that make complex concepts come to life. You'll explore the #science behind aging and cancer, learn how scientists discover the information presented in textbooks, and more in this three-part online series "Molecular Biology" from the MIT Department of Biology. Open now, self-paced. Learn more and enroll at https://bit.ly/47GExSE #onlineeducation #onlinecourse #onlinelearning #learnbiology #openeducation

Happy World Space Week!   As we celebrate everything space-related this week, we're excited to spotlight a fascinating project we previously supported using our high-quality cell lines.   Students from WARR Space Labs at the Technical University of Munich led the ASSONISS Project (Ageing and Degenerative Diseases of Neurons on the ISS). They explored how neuronal cell cultures behave in microgravity, using SH-SY5Y cell lines from AMSBIO.   This innovative research could significantly advance our understanding of neurodegenerative diseases, particularly Alzheimer's Disease, by studying signs of cell ageing which occur more rapidly in microgravity than on Earth.   At AMSBIO, we are proud to support research like this with our wide range of validated human cell lines, including receptor, ion channel, cell signalling, phosphodiesterase, and CRE recombinase lines. Our goal is to provide researchers with the highest quality tools to support your research. #AMSBIOSupports #NeurodegenerativeDiseases #CellsInSpace #WorldSpaceWeek #WSW2024   Learn more about the project here: https://lnkd.in/ejzYAXuC

We're excited to be at the Society for Neuroscience annual meeting, where we’re presenting a few scientific posters to on the collaborative efforts of the Digital In Vivo Alliance to use continuous home cage monitoring and computer vision to optimize insights derived from preclinical animal models. On Saturday, we presented our poster on using machine learning to more optimally detect seizures in preclinical animal models, and this morning we’ll be presenting our poster on how machine learning-informed digital measures can improve the sensitivity and translational relevance of in vivo neurodegenerative disease models.   Special thanks to all collaborators and coauthors, including Jennifer Leedy, Manuel (Manny) Lopez, Nicole Peltier, Ph.D., Timothy L. Robertson, Manny Ruidiaz, Michael Saul, Brian R. Berridge, Steve Ciciotte, Amy Clipperton-Allen, Michael Ellis, Paige Martin, and Cat Lutz.   If you're at SfN today, please come say hello and check out the poster (X14)! #digitalmeasures #preclinicalresearch #sfn2024 #DigitalInVivoAlliance

Meet the moderators!‼️ In this edition we will have 3 round tables in the end of each panel, moderated by: - José Mateus: Junior Researcher at Neuroengineering and Computational Neuroscience group - i3S. Currently, José is interested in building neuronal circuits in vitro with realistic connectivity, which can be probed with advanced electrophysiology and imaging techniques.🧠 - Hugo R. Caires: Junior Researcher at BeMIC - Bioengineered 3D Microenvironments-i3S. Hugo is currently focused on the development of a novel organ-on-a-chip technology to study Extracellular Vesicle-mediated cryptic infections in P. Vivax.🧫 - ⁠Delfim Duarte: Group Leader at Hematopoiesis and Microenvironments group-i3S. Delfim teams’ goals are to study the cell extrinsic regulation of leukemia and hematopoiesis at the local and systemic levels and to unravel new biological mechanisms in leukemia through in vivo studies. 🧬 Join us on the 21st of June at the XI BiotechHealth Symposium and participate in these super relevant discussions. 💡