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Effect of Oral Intake of Carrot Juice on Cyclooxygenases and Cytokines in Healthy Human Blood Stimulated by Lipopolysaccharide Our research unit looked into the effects of consuming carrot juice on inflammation markers in healthy human blood. Here's a glimpse into the findings: 📊 Overview: The study was an experimental intervention examining how carrot juice intake influenced the production of cyclooxygenases and cytokines in blood stimulated by lipopolysaccharide (LPS), a compound known to induce inflammation. 🔍 Key insights:  · The intake of carrot juice significantly reduced the production of certain pro-inflammatory cytokines in LPS-stimulated blood.  · There was a notable decrease in cyclooxygenase-2 (COX-2) enzyme levels, which are associated with inflammation and pain.  · The anti-inflammatory effects are attributed to bioactive compounds found in carrot juice, such as polyacetylenes. 💡 Research implications: The study contributes valuable insights into the potential anti-inflammatory benefits of carrot juice, suggesting that regular consumption might help modulate inflammatory responses in humans. Further investigation is needed to explore the long-term effects and potential clinical applications of these findings. 📚 Read the full article here:  https://lnkd.in/dukpUXWX

National Kidney Month raises awareness about kidney health, urging individuals to support kidney disease research and prioritize maintaining their kidney health. Some tips to keep your kidneys healthy, is to cut down on sodium and sugar, include whole grains and low-fat dairy in your diet, and maintain a regular exercise routine. ERG is one of the largest research organizations in the nation focusing on the conduct of clinical trials and we are committed to research and development in kidney health treatments. Clinical Pharmacology of Miami and Endeavor Clinical Trials, which are part of ERG's Portfolio group, are presently seeking volunteers for their kidney disease trials. This presents a special chance to contribute to medical advancements and scientific innovations! Click here to learn more information and to learn about our current studies: Evolution Research Group | Research Network | Join a Research Study To learn more about Evolution Research Group please visit:  www.ergclinical.com

🔬 Recent research by Professor Brenda Kwak's group sheds light on the critical role of pannexin1 (#Panx1) in regulating fat metabolism and energy use during cold exposure. Panx1-deficient mice showed surprising adaptations in fat cell function, which are exacerbated upon cold exposure, an effect that appears to be associated with Ucp1-independent thermogenesis. Could this be the key to new metabolic therapies? 💊 Read it in Biomolecules MDPI! 🔗 https://lnkd.in/dvQfKNTK By: First and corresponding author Filippo Molica, group leader GCIR Prof. Brenda Kwak, co-authors marc chanson, Christophe Montessuit, Olga Martyna Rusiecka, Graziano Pelli, Avigail Ehrlich. Faculté de médecine - UNIGE, University of Geneva. Summary: 🔗 https://lnkd.in/dhhik2Sg #Adipocytes #Browning #Cold #Thermogenesis #Pannexin1 #MitochondrialGenes #Ageing #Aging #Rejuvenation #Insulin #Diabetes #FatMetabolism #Obesity #FatMass #AdiposeTissue #ChronicColdExposure #ScientificPublication

#HighlyCitedPapers   📝 Plasma Metabolomics and Machine Learning-Driven Novel Diagnostic Signature for Non-Alcoholic Steatohepatitis — Ji, et al.   In this paper, the authors aimed to develop a diagnostic index for NASH based on metabolites that we found to be related to NAFLD progression.   Full text is available 👇 https://lnkd.in/gbnc_9-H   #medicine #health #research #science

Scientists identify how fasting may protect against inflammation In research published in Cell Reports, the team describes how fasting raises levels of a chemical in the blood known as arachidonic acid, which inhibits inflammation. The researchers say it may also help explain some of the beneficial effects of drugs such as aspirin. Scientists have known for some time that our diet – particular […] https://lnkd.in/dxhtA3F7 Cyprus-CEO #CEO #business #management #marketing #tech #AI #legal #money

Wiley: Clinical and Translational Science: Machine learning identifies fatigue as a key symptom of fibromyalgia reflected in tyrosine, purine, pyrimidine, and glutaminergic metabolism (Zetterman et all 2024) "What question did this study address? Through data-driven analysis, we assessed the impact of individual symptoms in fibromyalgia; metabolic differences between fibromyalgia patients and healthy controls at baseline and in stress responses; and the association of the most significant symptom and metabolism. "What does this study add to our knowledge? Our results highlight the impact of fatigue on fibromyalgia symptom burden. We also indicate tyrosine, purine, and pyrimidine pathways as well as changes in metabolites involved in glutaminergic neurotransmission as possible pathophysiological mechanisms of fibromyalgia, and 5-hydroxyindole-3-acetic acid and glutamine as associating with fatigue in fibromyalgia. Importantly, most of the metabolic findings only became evident in stress responses." https://lnkd.in/e4mtdjNY #Fibromyalgia #Fibro #Fatigue #MetabolicSignature #Metabolites #Metabolism #CardioPulmonaryExerciseTest #CPET #Research 

Lipedema is a metabolic condition that primarily affects women, and it suffers from a lack of a clear, consensus definition. Such conditions are often neglected within the healthcare system due to the difficulties in making definitive diagnoses for complex issues with no distinct pathognomonic causes. This poses challenges for research and the development of effective treatments for a likely diverse patient population. However, the authors of the just published “Proposed Framework for Research Case Definitions of Lipedema” have made significant contributions with their objective review of the literature and their efforts to construct a framework that could bolster future research (https://lnkd.in/eJQYtXfD). Meanwhile, personalized treatment remains a critical strategy for identifying effective patient care solutions. There is growing evidence that dietary interventions, such as the ketogenic diet, may offer benefits beyond the mere effect of weight loss, including the alleviation of pain and touch sensitivity. SiPhox Health is honored to sponsor the upcoming Lipedema Project Lipedema Simplified LLC Heart to Heart Virtual 3-day Conference: Keto and Beyond (https://bit.ly/49lNfXq). We anticipate that our platform, which allows comprehensive biomarkers to be tested frequently and easily at home, will be a valuable resource for both patients and healthcare providers, guiding decision-making and enhancing patient outcomes. See my conversation with Leslyn Keith, the Director of Reseach and President of the Board of Lipedema Project to learn more about the SiPhox Health platform and recently beta-launched Heart Health Blueprint: https://lnkd.in/ejWpJsts

📯Physiological Effects and Human Health Benefits of Hibiscus sabdariffa: A Review of Clinical Trials Hibiscus sabdariffa Linn. Malvaceae (HS) is characterized by its edible calyxes. The HS calyxes are widely used for cosmetic, food, and medicinal applications. According to ethnobotanical evidence, decoction, infusion, or maceration extracts from HS calyxes have been used in folk medicine to treat many ailments. Moreover, several in vitro and in vivo studies have demonstrated the pharmacological properties and potential human health benefits of HS consumption. On the other hand, the evaluation of the physiological effects and health benefits of HS in clinical studies is most challenging. Therefore, this narrative review summarizes and discusses the physiological effects and health benefits of HS calyxes reported in clinical trials. Preparations obtained from HS calyxes (extracts, infusions, decoction, teas, beverages, capsules, and pills) are used as non-pharmacological therapies to prevent/control diverse chronic non-communicable diseases. The most-reported HS health benefits are its antihypertensive, antidyslipidemic, hypoglycemic, body fat mass reduction, nephroprotective, antianemic, antioxidant, anti-inflammatory, and anti-xerostomic activities; these effects are associated with the phytochemicals found in HS. Moreover, no adverse effects were reported during the clinical trials. However, clinical studies exhibited some limitations; thus, further studies are required to validate the clinical efficacy of HS in large-scale studies with higher doses and a good experimental design. MDPI and ACS Style Montalvo-González, E.; Villagrán, Z.; González-Torres, S.; Iñiguez-Muñoz, L.E.; Isiordia-Espinoza, M.A.; Ruvalcaba-Gómez, J.M.; Arteaga-Garibay, R.I.; Acosta, J.L.; González-Silva, N.; Anaya-Esparza, L.M. Physiological Effects and Human Health Benefits of Hibiscus sabdariffa: A Review of Clinical Trials. Pharmaceuticals 2022, 15, 464. https://lnkd.in/dNnDiPsX #hibiscus #health #benefit #teascience #overweihgt

📃Scientific paper: Oxidation of TDMQ20, a Specific Copper Chelator as Potential Drug Against Alzheimer's Disease Abstract: International audience; Developed as a regulator of copper homeostasis in the brain of patients affected by Alzheimer's disease (AD), TDMQ20 is a specific copper(II) chelator able to restore short term memory in AD mice. To anticipate on metabolic studies of this drug-candidate, here we report the catalytic oxidation of TDMQ20 by a biomimetic system reminiscent of P450 oxidation, using a metalloporphyrin and hydrogen persulfate as oxidant. Oxidation products were mainly characterized by HPLC with UV-visible spectrometry or high-resolution mass spectrometry detection. In these conditions, TDMQ20 was readily oxidized by aromatic hydroxylation, oxidation of 1,4-diphenol or 1,4-aminophenol to 1,4-quinone or quinone-imine, respectively, or oxidative chlorination. These putative metabolites were water-soluble, suggesting that the drug-candidate might be easily metabolized and excreted in vivo. Continued on ES/IODE ➡️ https://etcse.fr/UvYw ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health

📃Scientific paper: Oxidation of TDMQ20, a Specific Copper Chelator as Potential Drug Against Alzheimer's Disease Abstract: International audience; Developed as a regulator of copper homeostasis in the brain of patients affected by Alzheimer's disease (AD), TDMQ20 is a specific copper(II) chelator able to restore short term memory in AD mice. To anticipate on metabolic studies of this drug-candidate, here we report the catalytic oxidation of TDMQ20 by a biomimetic system reminiscent of P450 oxidation, using a metalloporphyrin and hydrogen persulfate as oxidant. Oxidation products were mainly characterized by HPLC with UV-visible spectrometry or high-resolution mass spectrometry detection. In these conditions, TDMQ20 was readily oxidized by aromatic hydroxylation, oxidation of 1,4-diphenol or 1,4-aminophenol to 1,4-quinone or quinone-imine, respectively, or oxidative chlorination. These putative metabolites were water-soluble, suggesting that the drug-candidate might be easily metabolized and excreted in vivo. Continued on ES/IODE ➡️ https://etcse.fr/UvYw ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health