Johan Gielis’ Post

Shocking Allegations of Research Misconduct at Dana-Farber/Harvard A recent article by Sholto David in Forbes raises serious concerns about potential research misconduct at the Dana-Farber Cancer Institute (DFCI) at Harvard University. The article details several instances of published research containing manipulated data, casting a shadow over the integrity of the institution's scientific output. While some of the researchers involved have responded to the criticisms, the article argues that DFCI and Harvard have not taken adequate steps to address these concerning issues. This lack of transparency and accountability is deeply troubling and demands a thorough investigation to ensure the credibility of future research conducted at these esteemed institutions. https://lnkd.in/e6wEUb7U Another article from Nature's concerning integrity of data. https://lnkd.in/eR2js8mU #scienceintegrity #researchmisconduct #DFCI #Harvard

For Better Science: This guest blog by Sholto David regarding science fraud in the billion dollar cancer research industry is enlightening and disturbing, delving into the research of prestigious professors, researchers and executives. PubPeer is shown to be a valuable resource as well. https://lnkd.in/gHgj-WFh

Let's reframe brain donation sensitivity. It's about honoring legacies, empowering choice, and fostering hope for the future of medical #research. Let's celebrate the incredible generosity of individuals like Albert #Einstein (#brain anatomy studies), Sylvia Plath (#depression and #mental illness research), Muhammad Ali (#Parkinson's disease understanding), Henry #Molaison (#memory formation insights), Robin Williams (#Lewy body #dementia research), and Terry Pratchett (#Alzheimer's research), who chose to donate their brains for scientific research. Their selfless acts have paved the way for groundbreaking discoveries in #neuroscience! Let's approach this topic with compassion and understanding, respecting privacy and addressing concerns openly. Together, we can make a positive difference in the world of neuroscience! #BrainDonation #MedicalResearch #CompassionAndHope https://lnkd.in/gGkyrzpj

Brain donation is not as simple as becoming an organ donor. From enrollment to collection, it’s a delicate and complex process. But, the impact on neuroscience can be profound with some brains still being studied 30+ years after donation. Learn more at https://lnkd.in/ghzYpvmJ Brain donation diversity, including healthy brains, is critical to unlocking what goes wrong in disease. Learn more about the process and how to enroll: 🧠 The National Institutes of Health - https://lnkd.in/eMmvQ8D 🧠 UW Medicine - https://lnkd.in/gF_sNcHv 🧠 Brain Donor Project - https://lnkd.in/dHNaVBx #BrainWeek #BrainAwarenessWeek #Alzheimers #EndAlz #Neuroscience

🔐Producing this annual report was a cool exercise of coding and decoding Champalimaud Research (CR) in the great company of Marta Correia & Hedi Young. 💡From the first idea of creating a graphical code, which would let invisible things about CR emerge, to this document, we came a long way. 🔎Hope you get to find out something interesting about CR in this report! 💫Last, but not least, big thanks to everyone who, one way or another, contributed to this report and stay tuned for the printed version, which will be out soon! #annualreport #code #decode #design #scicom #scicomm

🔬 Transforming Research into Everyday Moments ⭐ Associate Professor Quenten Schwarz is on a mission to change lives. As a leading expert in neurovascular research, his work at the Centre for Cancer Biology (University of South Australia and SA Pathology) focuses on understanding and conquering childhood cancers and neurodevelopmental disorders. From neuroblastoma to autism, his research aims to make a profound difference for families affected by these conditions. Quenten's commitment goes far beyond the lab. As a father, he’s deeply moved by stories like Edwina’s—a brave young girl who fought neuroblastoma and now inspires countless others. “Her story is a powerful reminder of why we need better treatments,” he says. With your support you can help drive this critical research and bring hope for countless ‘everyday’ moments for families like Edwina’s. Learn more about Quenten's powerful work: https://lnkd.in/gT9Umr6T #HospitalResearch #MedicalResearch #ChildhoodCancerAwareness #EverydayMiracles #TogetherFight

Over the last 6 years, we've invested £1.8 million to fund innovative and ground-breaking research to find new treatments to give the gift of time to those affected by a brain tumour diagnosis. In order to double survival and halve the harm done by brain tumours, we need to make sure exceptional researchers are encouraged to work in the field of neuro-oncology – now and in the future. From helping to establish the next generation of leaders within brain tumour field with our Future Leaders programme, to supporting established researchers to continue their projects with our Senior Fellowship award, we have a range of funding initiatives to support the scientific community to further our understanding of brain tumours. It’s only by continuing to invest in cutting-edge research that we can truly accelerate a cure. Tap the link below to donate today and help us fund more research to help those affected by a brain tumour live longer and better.https://bit.ly/476nZTU

📍 Personalized deep brain stimulation for Parkinson’s disease A personalized, adaptive system significantly reduced Parkinson’s symptoms and improved quality of life compared with standard deep brain stimulation. Results from the small study will need to be confirmed in larger groups. Excerpt: A treatment called deep brain stimulation (DBS) is used to help some people manage the motor symptoms of Parkinson’s disease. In DBS, fine wires called electrodes are implanted into the brain at specific locations. These wires then deliver electrical signals that can lessen bothersome movement problems. Conventional DBS provides a constant level of stimulation to the brain. It doesn’t adapt to natural fluctuations in brain activity. It also can’t account for changes in levels of medications in the body that people with Parkinson’s may take to boost their dopamine levels. This can lead to unwanted movement effects. A research team led by Drs. Simon Little and Philip Starr from the University of California, San Francisco has been developing a technique called adaptive DBS (aDBS). In aDBS, a machine learning system constantly measures changes in brain activity related to movement and adjusts the stimulation, in real time. The system measures activity in areas of the brain called the subthalamic nucleus and sensorimotor cortex. Measuring activity in these areas, the team found, could predict bothersome motor symptoms. The system then uses this information to change stimulation levels to prevent the symptoms. In a new study, funded in part by NIH’s BRAIN Initiative, the team tested their system in four volunteers whose Parkinson’s symptoms hadn’t been adequately controlled with conventional DBS. The systems could deliver either conventional DBS or personalized aDBS. Over a period of one month, participants were randomly switched between conventional DBS and aDBS for blocks of several days at a time. The participants weren’t told which type of stimulation they were receiving at any time. Results were published on August 19, 2024, in Nature Medicine. Read➡️ https://lnkd.in/eSFkpqnX #parkinsons

These two books should be required reading in medical school - Aaron Goodman #Cancer #NCCN #OncoDaily #Oncology #Pathology #MedicalSchool #UniversityOfCalifornia

Check out this story written by my colleague and friend!