Jose Lin’s Post

[#BioguardProduct] Avian hepatic disease can present with vague symptoms, making it difficult to distinguish from other conditions. Although clinical enzymology is commonly used, it only indicates hepatocyte injury without revealing the chronicity or severity of the disease. Diagnostic imaging can help identify hepatomegaly and ascites, but a definitive diagnosis requires histological examination. Treatment for avian hepatic disease involves providing palliative care, addressing the specific illness, and creating an optimal environment for liver healing. Biochemistry results may show various anomalies, and our miniCHEM Biochemistry Analyzer efficiently analyzes key markers for precise results in just 12 minutes. This analyzer is tailored for various species with minimal sample volume.

As the availability of real-world data grows, opportunities to leverage it are growing. How can #pharmacoepidemiology studies benefit from Target Trial Emulation Frameworks when addressing causal inference? Learn more with today's blog 👉🏼 https://ow.ly/tWoR50QAn35 #realworlddata #realworldevidence #causalinference

Gut microbiome alterations at acute myeloid leukemia diagnosis are associated with muscle weakness and anorexia. The gut microbiota makes critical contributions to host homeostasis, and its role in the treatment of acute myeloid leukaemia (AML) has attracted attention. We investigated whether the gut microbiome is affected by AML, and whether such changes are associated with cachectic hallmarks. Biological samples and clinical data were collected from 30 antibiotic-free AML patients at diagnosis and matched volunteers (1:1) in a multicenter cross-sectional prospective study. The composition and functional potential of the faecal microbiota were analyzed using shotgun metagenomics. Faecal, blood, and urine metabolomics analyses were performed. AML patients displayed muscle weakness, anorexia, signs of altered gut function, and glycaemic disorders. The composition of the faecal microbiota differed between patients with AML and control subjects, with an increase in oral bacteria. Alterations in bacterial functions and faecal metabolome support an altered redox status in the gut microbiota, which may contribute to the altered redox status observed in patients with AML. Eubacterium eligens, reduced 3-fold in AML patients, was strongly correlated with muscle strength and citrulline, a marker of enterocyte mass and function. Blautia and Parabacteroides, increased in patients with AML, were correlated with anorexia. Several bacterial taxa and metabolites (e.g. Blautia, Prevotella, phenylacetate, and hippurate) previously associated with glycaemic disorders were altered. Our work revealed important perturbations in the gut microbiome of AML patients at diagnosis, which are associated with muscle strength, altered redox status, and anorexia. These findings pave the way for future mechanistic work to explore the function and therapeutic potential of the bacteria identified in this study. Source: Haematologica https://lnkd.in/ednA4uSR

The article highlights xenotransplantation, particularly the case of Lawrence Faucette, who received a genetically modified pig heart due to the severe shortage of human organ donors. This experimental approach, fueled by gene editing and cloning advances, shows promise in addressing the growing need for transplant organs. Despite successful trials, xenotransplantation faces challenges like organ rejection and ethical concerns. It represents a significant step in medical innovation, offering hope for many awaiting transplants while navigating new scientific and ethical frontiers. Hashtags: #Xenotransplantation #OrganTransplant #MedicalInnovation #GeneEditing #PigHeartTransplant #HealthcareBreakthrough #OrganDonorShortage #EthicalChallenges #LifeSavingResearch #FutureOfTransplants

𝗠𝗼𝗹𝗲𝗰𝘂𝗹𝗮𝗿 𝗱𝗶𝘀𝘀𝗲𝗰𝘁𝗶𝗼𝗻 𝗼𝗳 𝗰𝗼𝗯𝗿𝗮 𝘃𝗲𝗻𝗼𝗺 𝗵𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀 𝗵𝗲𝗽𝗮𝗿𝗶𝗻𝗼𝗶𝗱𝘀 𝗮𝘀 𝗮𝗻 𝗮𝗻𝘁𝗶𝗱𝗼𝘁𝗲 𝗳𝗼𝗿 𝘀𝗽𝗶𝘁𝘁𝗶𝗻𝗴 𝗰𝗼𝗯𝗿𝗮 𝗲𝗻𝘃𝗲𝗻𝗼𝗺𝗶𝗻𝗴. Researchers performed a whole-genome CRISPR knockout screen to identify genes necessary for the cytotoxicity of spitting cobra venom. This screen revealed genes involved in proteoglycan biosynthesis, indicating that heparinoids might be able to inhibit the cytotoxic effects of spitting cobra venom.” #venom #antidote #cobra #medicine #crispr #genome #tropicaldisease

📢 Excited to share our latest research published in the International Journal for Parasitology! 🐾 Our team investigated risk factors for the progression of Canine Leishmaniosis (CanL) in a cohort study spanning over 20 years. Highlights: 🔍 Risk factors shaping host-parasite interactions impact the clinical management of canine leishmaniosis. 👁️ Renal and ocular findings are major risk factors for LeishVet stages III and IV. 💡 Diagnosis of comorbidities is key to managing dogs with leishmaniosis, although independent of their clinical outcome. 🧬 A complex polygenic component underlies the development of severe clinical forms of leishmaniosis in certain purebred dogs. 🛡️ Protective immunity against *Leishmania* parasites is related to genetic factors involved in the endoplasmic reticulum (ER) stress and unfolded protein response (UPR) pathways. Congratulations to Carolina R. Sanz for this article, the third of her doctoral thesis. Read the full article here: https://lnkd.in/dSB9AEXC #CanineLeishmaniosis #Parasitology #Research #DogHealth #VeterinaryScience #Genetics #Immunity #DogCare #LeishVet #SciencePublication 📚

Toxoplasmosis is a worldwide endemic disease caused by the parasitic protozoa Toxoplasma gondii, although prevalence is generally higher in areas of the world that have hot, humid climates and lower altitudes. It infects a broad spectrum of vertebrate hosts, including humans. People typically become infected by: Foodborne, Animal-to-human (zoonotic), Mother-to-child (congenital), Blood transfusion or organ transplantation. The diagnosis of toxoplasmosis can be made by: serologic testing, isolation of the parasite, direct observation of the parasite and molecular techniques. 👉At Rekom Biotech we have many IVD reagents for Toxoplasmosis diagnosis in humans and animals. Do not hesitate to take a look at our website to find IVD reagents for your assay development! #IVDreagens #toxoplasmosis

Clostridium Question And Answers https://lnkd.in/gtkkZ_Me Clostridium Symptoms of Established Disease Laboratory Diagnosis of Gas Gangrene Methods of tetanus prophylaxis are Summary of Tetanus Prophylaxis #science #biotechnology #bacteria #biochemistry #molecularbiology #laboratory #genetics #medical #microscopy

There are many gaps in testing Fungal samples in #MolecularDiagnostics which can be listed here: - Absence of molecular techniques for mucormycosis detection. Lack of an effective diagnostic algorithm utilizing fungal biomarkers and molecular tools for early and accurate diagnosis of Pneumocystis pneumonia, aspergillosis, candidemia, and endemic mycoses. - Absence of a standardized molecular method to directly identify fungal pathogens in formalin-fixed, paraffin-embedded tissues. - Insufficient databases to improve mold identification using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. - Suboptimal approaches for mold blood cultures, tissue culture processing for Mucorales, and fungal respiratory cultures in cystic fibrosis patients. - Limited capacity for point-of-care testing targeting new, emerging, or less recognized fungal pathogens. - Need for improved antifungal susceptibility testing performance. https://lnkd.in/gmwAxTWX #CLIA #CAP #COLA #clinicallaboratory #Infectiousdisease

🐴Strangles🐴 📋Causative Agent: Streptococcus equi subsp. equi. Involves the upper respiratory tract with abscessation of regional lymph nodes. More severe in horses 1–5 years of age. 🐎Transmission: Highly Contagious via upper respiratory purulent exudates or from discharging abscesses. Horses can shed the bacteria before developing clinical signs, or up to 6 weeks later. There is also a chronic carrier state when the bacteria are present in the guttural pouch. 🩺Clinical Presentation: • Multiplication in lymph nodes causing abscesses.  • High fever, depression, anorexia • Oculonasal discharge turning purulent • Swollen and painful head/neck lymph nodes • Submandibular nodes are affected and they can rupture discharging purulent, highly infectious material • Guttural pouch empyema is also a common finding 🔬Diagnosis: Culture or PCR of abscess material or washes from guttural pouch or nasopharynx. 🧫👩🔬This clinical case is of a submandibular abscess in a horse, purulent exudate was submitted to the laboratory, and after overnight incubation we could observe pure growth of small mucoid Beta-haemolytic colonies. MALDI-TOF identified the isolate as Streptococcus equi subsp. equi, and in the direct smear pictures of the pus, we can observe the characteristic long chains of Gram-positive cocci, along with many neutrophils. #veterinarymedicine #microbiology #equinehealth #medicinaveterinaria