The Journal of Clinical Investigation’s Post

AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments: https://buff.ly/49vRjVc Authors Wenrui Zhang, Lu Cao, Jian Yang, Shuai Zhang, Jianyi Zhao, Zhonggang Shi, Keman Liao, Haiwei Wang, Binghong Chen, Zhongrun Qian, Haoping Xu, Linshi Wu, Hua Liu, Hongxiang Wang, Chunhui Ma, Yongming Qiu, Jianwei Ge, Jiayi Chen, Yingying Lin #Oncology

Our latest publication in Trends in Pharmacological Sciences (TIPS): Leveraging Spatial Omics for the Development of Precision Sarcoma Treatments As part of our ongoing research at The Frazer Institute, we are thrilled to share our latest opinion piece. Authored alongside our brilliant PhD student, Cui (Maxine) Tu, Dr. Arutha Kulasinghe & Prof. Andrew Barbour Translational Research Institute Australia #FrazerInstitute The University of Queensland, this article delves into the promising field of spatial omics and its application in pediatric sarcoma treatment. Pediatric sarcomas, while rare, pose significant treatment challenges due to their heterogeneity. Traditional therapies have seen little innovation over the past decades, often falling short in addressing the unique complexities of these cancers. 🔍 In our article, we address a pivotal question: How can spatial omics technologies revolutionize our understanding of the tumor microenvironment in pediatric sarcomas? We discuss the potential of these technologies to uncover new therapeutic targets and to facilitate the development of more effective, personalized treatment strategies. 🧬 This publication underscores the importance of innovative research in transforming cancer treatment and highlights the potential of spatial omics as a tool for precision medicine. We invite our colleagues, fellow researchers, and anyone interested in the latest advancements in oncology and precision medicine to read and share their thoughts on our findings. Read the full article here: https://lnkd.in/gWeF6tFQ #SarcomaResearch #SpatialOmics #PrecisionMedicine #PediatricOncology #CancerResearch #InnovationInHealthcare

In Côte d'Ivoire, unity is strength in the management of central nervous system tumors in children. This study assessed the contribution of multidisciplinary team meetings to the clinical management of central nervous system tumors in children. "Landry Drogba, Grace Djonde, Esperance Broalet, Marc Gbazi, Raissa Diaby, Dominique Ndri Oka, PAEDIATRIC-15 MANAGEMENT OF PEDIATRIC CENTRAL NERVOUS SYSTEM TUMORS BY A NEURO-ONCOLOGY MULTIDISCIPLINARY TEAM : OUR EXPERIENCE, Neuro-Oncology Advances, Volume 5, Issue Supplement_4, November 2023, Page iv11, https://lnkd.in/eeY7pRP3 " Landry Drogba; Grace DJONDE; Esperance Broalet; Marc Gbazi #oncology #cancer #tumor #neurology #nervous central system #surgery #radiotherapy #chemotherapy #childtumor #multidisciplinary

Sharing the recent interview of Dr. Dundee with ABC Radio Melbourne, Australia. https://lnkd.in/euArFqZH Dr. Dundee, urology surgeon and the Principal Investigator of Comphya clinical study in Melbourne, sheds light on the insidious challenges faced by prostate cancer patients, particularly the concerning side effect of erectile dysfunction. He emphasizes that Comphya's unique technology could be a "game-changer" and has the potential to revolutionize the rehabilitation of erectile function post-prostatectomy. Importantly, Dr. Dundee highlights that early testing for prostate cancer can save lives. Along these lines, he also clarifies that the goal of Comphya’s investigational technology  under clinical study is to minimize the side effects of prostate cancer treatment that terrify patients. Ultimately, the objective is to enable men that will undergo prostate cancer treatment to return to their normal quality of life, recovering lost erectile function. The clinical trials are underway; stay tuned for updates. #prostatecancer #prostatectomy #neurostimulator #neuromodulator #erectiledysfunction #innovation #clinicaltrials

Response rates to immune checkpoint blockade (ICB) are generally higher in metastatic brain cancer than in recurrent glioblastoma. Researchers from UCLA Neurosurgery, including Robert Prins, PhD, Won Kim, MD, Linda Liau, MD, PhD, MBA, and Richard Everson, MD, and colleagues have identified distinct alterations in the immune landscapes of the tumor microenvironments in these different tumor types. In addition, the researchers have outlined a framework for how these insights might be translated to enhance immunotherapeutic strategies for these cancers. Read the full article here: https://lnkd.in/gKDCbTSP

Spotlighting HIFU physicians across the US sheds light on urologists enhancing communities by offering HIFU for men with localized prostate cancer. In a recent interview, James Bienvenu, MD from University Urology and UT Medical Center in Knoxville, Tennessee, shares insights on prostate cancer diagnosis, focal therapies, and the impact of HIFU in the landscape. Dr. Bienvenu highlights how HIFU spares crucial prostate areas, maintaining erections and urinary control. Patients recover swiftly post-catheter removal with minimal side effects, showcasing the efficacy of this treatment. HIFU Prostate Services enjoys working with Dr. Bienvenu and his team at UTMC to provide Sonablate HIFU in TN, ensuring patient accessibility and educating urologic residents on its benefits. Explore more about Dr. Bienvenu's pioneering work in prostate cancer treatment: https://lnkd.in/eaM4kVXM #healthcare #prostatecancer #urology #hifu #patientcare #qualityoflife #cancertreatment #Sonablate #hospitals #experience #minimallyinvasive

This week on BackTable Urology, Dr. Seth Lerner (Baylor College of Medicine) discusses the intricacies of lymph node dissection in bladder cancer management, including an overview of patterns of metastasis, genomic classifiers, and recent clinical trials. The discussion highlights the evolution of bladder cancer treatment, from the use of cytotoxic chemotherapy to the current practice of neoadjuvant chemotherapy and radical cystectomy. Dr. Lerner and Dr. Bagrodia further explore diagnostic and treatment strategies, including the role of Decipher Prostate Genomic Classifier in tailoring patient treatment plans. The podcast delves into the necessity of a multidisciplinary approach to bladder cancer, the benefits of multimodal therapy, and the integration of circulating tumor DNA in management plans. Dr. Lerner then discusses clinical trials assessing the impact of extended lymph node dissection during cystectomies and emphasizes the importance of surgical quality and adherence to established protocols in bladder cancer treatment. Listen now: https://lnkd.in/gMybp7pT #bladdercancer #bladderhealth #urology #urologist #meded #medtech #backtable Decipher by Veracyte

This week on BackTable Urology, Dr. Seth Lerner (Baylor College of Medicine) discusses the intricacies of lymph node dissection in bladder cancer management, including an overview of patterns of metastasis, genomic classifiers, and recent clinical trials. The discussion highlights the evolution of bladder cancer treatment, from the use of cytotoxic chemotherapy to the current practice of neoadjuvant chemotherapy and radical cystectomy. Dr. Lerner and Dr. Bagrodia further explore diagnostic and treatment strategies, including the role of Decipher Prostate Genomic Classifier in tailoring patient treatment plans. The podcast delves into the necessity of a multidisciplinary approach to bladder cancer, the benefits of multimodal therapy, and the integration of circulating tumor DNA in management plans. Dr. Lerner then discusses clinical trials assessing the impact of extended lymph node dissection during cystectomies and emphasizes the importance of surgical quality and adherence to established protocols in bladder cancer treatment. Listen now: https://lnkd.in/gkJkMd-A #bladdercancer #bladderhealth #urology #urologist #meded #medtech #backtable Siamak Daneshmand John Sfakianos Mark Preston Mohit Khera Richard Link Badar M. Mian Alexander Kutikov, MD, FACS Mohummad Minhaj Siddiqui Mary Beth Westerman Phillip Pierorazio Javier-DesLoges Juan Aaron Fritts MD Bryant Schmitz Quynh-Chi (Chi) Dang Quoc-Dien Trinh David Canes Decipher by Veracyte

📣📣 📣 Clinically Significant Prostate Cancer Detection Following Transrectal and Transperineal Biopsy: Results from the ProBE-PC randomized clinical trial 🔹840 men 🔹MRI/ultrasound fusion technique 🔹Targeted AND systematic biopsy 🔹No difference noted in the clinically significant prostate cancer detection rates https://lnkd.in/dggB46K4 Albany Medical Center American Urological Association #cancer #prostate #RCT #urology #academic

A phase 1/2 trial explores CALEC transplantation, rehabilitating a diseased eye with cells grown from a small biopsy of the healthy eye. Promising initial results prompt expansion. Mass. Eye and Ear https://lnkd.in/em_UYtus