The Journal of Clinical Investigation’s Post

Bone Marrow Monocytes: The Unexpected New Players in Non-Alcoholic Liver Diseases - https://scft.link/AMQ6L Professor Rachel Golub and Dr Elsa Bourayou's research at the Institut Pasteur has revealed how bone marrow monocytes control immune responses in non-alcoholic steatohepatitis. Published in Cell Reports, the study highlights a vital inter-organ communication impacting liver health. #LiverDisease #Monocytes #Immunology #CellReports #sciencefeatured #sciencenews

Researchers from the La Jolla Institute for Immunology and the University of Southampton have discovered a breakthrough in severe asthma treatment. According to their study, airway tissue-resident cytotoxic CD4 T cells may play a crucial role in asthma pathogenesis. This discovery could pave the way for better stratification of severe asthma patients and new therapies. The current paradigm suggests that CD4+ TH2 cells play a central role in asthma pathogenesis, but less than 50% of patients respond to treatments. The effects are neither durable nor reverse airway remodeling, which progressively leads to permanent airflow obstruction. The discovery of tissue-resident cytotoxic CD4 T cells presents a new avenue for treating severe asthma patients. #SevereAsthma #AsthmaTreatment #MedicalResearch https://lnkd.in/evUu-ZXQ

#immunology #breastmilk #microbiome #infectioncontrol https://lnkd.in/gQMz4dRu #Breast #milk is known to contain #antibodies and other immune mediators that provide immune protection and shape the gut #microbiota. It also contains complement proteins — however, their physiological role was unclear. A study by Xu et al. shows that the complement components in mouse breast milk directly support a ‘protective’ gut microbiota in the neonate intestine by selectively eliminating specific Gram-positive bacterial species. The authors found that pups fostered by complement-deficient dams suffered from intestinal inflammation, barrier damage and increased lethality upon challenge with the natural mouse gut pathogen Citrobacter rodentium. Further analyses of the microbiota linked C. rodentium pathogenicity with the composition of intestinal commensals and, specifically, with an increased presence of Gram-positive Staphylococcus lentus B3. Complement from both mouse and human breast milk was found to directly lyse S. lentus B3 via C1-initiated mechanisms that required the formation of membrane attack complex but was independent of antibodies.

🚨𝐌𝐚𝐣𝐨𝐫 𝐁𝐫𝐞𝐚𝐤𝐭𝐡𝐫𝐨𝐮𝐠𝐡 𝐨𝐧 𝐈𝐁𝐃🚨 For the first time, a major trigger in inflammatory bowel disease (IBD). The breakthrough came as researchers discovered a part of DNA only active in some immune cells which causes inflammation in the bowels. Kudos to James Lee & his research team at the The Francis Crick Institute 👏🏼 As one of the 7 million people around world living with IBD, it brings me great joy seeing this. One of the hardest things to deal with is the uncertainty and how little we know about IBD!! #IBD #immunology

Please check our latest publication on "Selective production of IL-33-neutralizing autoantibody ameliorates asthma responses and severity", just published in Clinical Immunology (Impact factor: 8.6).

In immunology, patient-centered real-world research should be considered an essential part of your evidence development strategy. Catch up on our latest blog where we discuss how this type of research can add particular value in autoimmune and immune-mediated diseases. Read it here https://bit.ly/46YP4ZR #immunology #realworldresearch

Impact of Obesity on the IL-6 Immune Marker and Th17 Immune Cells in C57BL/6 Mice Models with Imiquimod-Induced Psoriasis body fat is an endocrine producer So Hee Park 1, Kyung Ah Lee 2, Jae-Hyeog Choi 3, SaeGwang Park 4, Dae-Wook Kim 5, So Young Jung 1 Affiliations expand PMID: 36982669 PMCID: PMC10059802 DOI: 10.3390/ijms24065592 Free PMC article Abstract Obese psoriatic patients experience higher disease severity and exhibit poorer treatment responses and clinical outcomes. It has been proposed that proinflammatory cytokines produced by adipose tissue exacerbate psoriasis; however, the role of obesity in psoriasis remains unclear. This study aimed to elucidate the role of obesity in the pathogenesis of psoriasis, focusing on immunological changes. To induce obesity, mice were fed a high-fat diet for 20 weeks. We then applied imiquimod to the skin on a mouse's back for seven consecutive days to induce psoriasis and scored lesion severity every day for seven days. Cytokine levels in serum and the Th17 cell population in the spleen and draining lymph nodes were studied to identify immunological differences. The clinical severity was more remarkable, and histologically the epidermis was also significantly thicker in the obese group. Increased levels of IL-6 and TNF-α were observed in serum after psoriasis. They were elevated to a greater degree, with greater expansion of the functional Th17 cell population in the obese group. It is concluded that obesity could exacerbate psoriasis through mechanisms that involve elevated proinflammatory cytokine secretion and an expanded Th17 cell population.

Oral health influences systemic health... *Oral bacteria have been found in atherosclerotic plaques. * Experiments in mouse models have shown that after inoculation with Porphyromonas gingivalis, there is a higher brain barrier permeability. * Fusobacterium nucleatum is present in higher amounts in patients with colorectal cancer than in healthy subjects. * Different epidemiological and experimental studies have indicated a positive correlation between a dysbiotic oral microbiome and a higher risk of developing Alzheimer’s disease, colorectal cancer, cardiovascular diseases, type 2 diabetes. These findings show that there is a strong link between the oral microbiome and the development of inflammatory diseases but periodontal interventions could be beneficial in the treatment of systemic inflammatory disease. The good news is that many of these inflammation-associated bacteria in the mouth are susceptible to nitric oxide. Reduce these bacteria in the mouth and restore nitric oxide-promoting oral microbiome with Prebiotics Nitrate Chewing Gum by MyFitStrip. #nitricoxide #alzheimers #type2diabetes #cancer #inflammation #microbiome #cardiovasculardisease #hypertension #obesity #diabetes #oralhealth #oralhygiene #periodontics #dentalhealth #consumerhealth #dentalhygiene #functionalnutrition #functionalmedicine #prebiotic #postbiotics #chewinggum #gummies #brainhealth

Small Peptides Offer New Hope for Autoimmune Disease Treatment - https://scft.link/hMtor Dr. Viktor Wixler and colleagues from Westfaelische Wilhelms-University of Muenster have published groundbreaking research on small spleen peptides (SSPs) in the journal Biomolecules. Their study reveals that SSPs modulate dendritic cell differentiation and extracellular ATP synthesis, offering promising new treatments for autoimmune diseases. #AutoimmuneDisease #Immunology #MedicalResearch #PeptideTherapy #BiomoleculesJournal #sciencefeatured #sciencenews

Exogenous IL-25 alleviates airway neutrophilia by inhibiting the polarization of macrophages toward the M1 phenotype and reducing the expression of IL-12 and IL-23 in asthma patients. This study suggests that IL-25 could be a potential therapeutic target for managing airway inflammation in asthma. #AsthmaResearch #Immunology