Journal of Integrative Neuroscience’s Post

A new study has revealed significant connection between the gut microbiome and aggressive behavior in mice. #antiaging #regenerativemedicine #neurosciences #neuroscience #medicine #microbiome #gut #guthealth #mentalhealth #clinicalresearch #health #wellness https://lnkd.in/gChUWrRH

The sortilin-related receptor, SORL1, might play a pivotal role in fueling tau aggregation in glial cells. In a groundbreaking study led by Bradley Hyman and Dudley Strickland, scientists uncovered that SORL1 binds tau and co-localizes with it in neuroglioma cells. 💡 Moreover, manipulating SORL1 levels impacted tau seeding, shedding light on its potential involvement in Alzheimer's pathology. 🔍 Read the full article now on Alzforum and stay ahead of the curve in Alzheimer's research. - https://bit.ly/4ahHGtf #ADPD2025 #ADPD2024 #alzheimers #parkinsons #dementia #endalz #neuroscience #neuroscientist #researcher

Happy to Share! Our newest research publication,"Network Pharmacology-Based Approach to Elucidate the Pharmacologic Mechanisms of Natural Compounds from Dictyostelium discoideum for Alzheimer's Disease Treatment" has just been published! In this study, our research team delve into the potential of secondary metabolites from Dictyostelium discoideum as multi-target treatments for Alzheimer's disease, using advanced network pharmacology methods. Their findings highlight nearly 50 potential targeting genes and multiple signaling pathways, with a particular focus on the neuroinflammatory pathway mediated by COX-2. For those interested in the detailed mechanisms and potential therapeutic effects of these natural compounds, check out our full article. We're happy to continue this line of research and contribute to the development of more effective AD treatments. Click the below link for the significant step towards understanding how natural compounds can be used more effectively in combating Alzheimer's disease. https://lnkd.in/dBZ-9eJR Authors: Dr. Mukul Jain, Nil Patil, Rupal Dhariwal, Lee Seong Wei, and Airfullah Mohammed Parul University Mukul Jain, PhD Patil Nil 🧠 Rupal Dhariwal #AlzheimersResearch #Pharmacology #Neuroscience #Publication #ResearchImpact #Cellpress #Heliyon #ComputationBiology #NetworkPharmacology #Neuro #NeuroDegeneration

CRISPR - short for clustered regularly interspaced short palindromic repeats. #antiaging #aging #regenerativemedicine #medicine #neurosciences #CRISPR #genetherapy #genome #neuroscience #science #clinicalresearch #research #medtech #healthtech #biotech #tech #innovation #health #wellness

A forward-genetics screen for GCase activity modulators identified Current therapeutic strategies targeting increased β-glucocerebrosidase (GCase) activity hold promise for Gaucher disease (GD) and Parkinson's disease (PD). Previously, we explored genetic modifiers of GCase activity https://lnkd.in/eeX9t-Uz. This study employs a complementary approach, utilizing a CRISPR activation library to identify modifying transcription factors (TFs) of GCase in the human glioblastoma cell line LN-229. These findings reveal 11 TFs as regulators of GCase activity. Ablation of USF2 resulted in increased GBA mRNA expression, leading to enhanced GCase protein levels and activity. This suggests USF2's role in repressing GBA transcription. Additionally, ONECUT2 was identified to control GCase trafficking through modulation of the guanine exchange factors PLEKHG4 and PLEKHG4B. This work significantly expands the understanding of the transcriptional landscape governing GBA regulation. By uncovering these novel regulatory factors, the study paves the way for potential therapeutic targets in GD and PD. The study is available as a Preprint: https://lnkd.in/eZpcwgJJ #genetics #genomics #precisionmedicine #genomicmedicine #brain #neurology #neuroscience #neurodegeneration #raredisease #gaucher #parkinson #biochemistry #therapeutics #biotechnology #innovation #research #science #sciencecommunication

𝗥𝘂𝗻 𝘆𝗼𝘂𝗿 𝘄𝗮𝘆 𝘁𝗼 𝗺𝗼𝘃𝗲 𝗮𝘄𝗮𝘆 𝗳𝗿𝗼𝗺 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿'𝘀 𝗱𝗶𝘀𝗲𝗮𝘀𝗲! or how physical exercice may induce the release of an enzyme that breaks down β-amyloid. 👉 A pathological hallmark of Alzheimer’s disease (AD) is the deposition of amyloid-β (Aβ) protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD mouse models but the involved mechanism has not yet been elucidated . Irisin, a myokine closely linked to exercise, has been described to have beneficial effects on cognitive and metabolic functions. 👉 Kim et al have studied the effects of irisin in 3D-AD culture and reported that irisin stimulates astrocytes to release an enzyme that breaks down β-amyloid. Importantly, the researchers have delineated the cellular and molecular mechanisms involved in the process. They found irisin’s ability to reduce Aβ levels is mediated by ERK-STAT3 signaling. Irisin maybe a novel therapeutic target to reduce Aβ burden for AD treatment and prevention? https://lnkd.in/eAYaicXe #alzheimer's #amyloid #irisin #neuroscience #brain #STAT #NF-kB

Fueled by a fascination with the brain and a desire to help others, I'm dedicated to uncovering the link between genetics and congenital brain malformations. I aspire to develop new treatments that improve the lives of patients. Through collaboration and continuous learning, I strive to make a lasting impact in neurogenetics. #clinicalgenetics #congenitalbrainmalformations #clinicalgenomics #genomicmedicine #humangenetics #medicalgenetics #neurogenetics #precisionmedicine

N-Acetyl Semax Amidate | The A-Z Guide Russian researchers created the nootropic peptide Semax in the 1980s, and N-Acetyl Semax Amidate is an improved form. N-Acetyl Semax Amidate and Semax have a seven-amino-acid sequence and are structurally similar. This sequence combines a portion of adrenocorticotropic hormone (ACTH, more precisely ACTH 4-7, or Met-Glu-His-Phe) with an extension at the C-terminus that reads Pro-Gly-Pro. https://lnkd.in/eeUgbM9b #Nootropics #Semax #BrainHealth #Neuroscience #Productivity #Russia #HealthyLiving #Community #MemoryBoost #organism #inflammation #neuroprotective #microcirculation #neurotoxic #experiments #peptide  #gastrointestinal #glaucoma TYCOONSTORY Wikipedia, the Free Encyclopedia ECHEMI Group Peptides created by BIIBLab-advanced biotech production platform

💡 Check out this video about how the BPGbio, Inc. NAi Platform utilizes Delta Network Analysis to gain insights that lead to groundbreaking discoveries! 💡 BPGbio, Inc.’s NAi platform comes with a powerful analytics tool - Delta Network Analysis. The Delta Network Analysis tool reveals the hidden molecular cause and effect interactions that are unique to a given treatment, providing insights that can lead to groundbreaking discoveries. Delta Network Analysis uncovers new pathways and mechanisms, offering novel biological insights. This powerful approach helps researchers identify new therapeutic targets and deepen our understanding of how treatments impact cellular processes. 👉 For more information about BPGbio, Inc. and the NAi Interrogative Biology Platform, please visit: https://lnkd.in/gvTXPEEf #NAiInterrogativeBiology #Biotech #Biopharma #Techbio #AIDrugDiscovery #AI #DrugDiscovery #Biomarkers #Therapeutics #Oncology #Neurology #RareDisease #Research

I am proud to announce that my recent systematic review titled "A systematic review of the association between the age of onset of spinal bulbar muscular atrophy (Kennedy's disease) and the length of CAG repeats in the androgen receptor gene" is now in-press! Kennedy's disease is a rare, adult-onset neuromuscular disorder with devastating consequences for both patients and their families. I am grateful to have had the opportunity to shed some light on this illness and contribute to the current effort to bring about change for those suffering from KD. #neuroscience #medicine #eneurologicalsci