Kathy Fraser’s Post

This systematic review by Marina Beraza Millor and colleagues analyzes the application of genetic substrate reduction therapy for the treatment of lysosomal storage diseases. #lysosomalstoragediseases #genetherapy #FabryDisease #openaccess https://lnkd.in/gJKmy_bs

This PK simulation-based analysis by Ashish Srinivasan and colleagues highlights the potential of using post-intensification infliximab trough thresholds associated with aspirational treatment targets in Crohn’s disease and ulcerative colitis to guide choice of infliximab dose intensification strategy. #inflammatoryboweldisease #infliximab #doseintensification #openaccess https://lnkd.in/gncJ8NHA

This study in BioDrugs compared plasma exposure of tocilizumab with intravenous vs. subcutaneous administration regimens in kidney transplant recipients with chronic active antibody-mediated rejection (CAAMR). #pharmacokinetics #Tocilizumab #kidneytransplantrecipient https://lnkd.in/gmJDm2Vi

Noninvasive skin imaging techniques provide new means for rapid, objective, quantitative, and accurate evaluation of acne scars. #acnescars #imaging https://lnkd.in/ggh-davW

This case-control study in the US by Gil Yosipovitch and colleagues demonstrated that patients with chronic spontaneous urticaria (CSU) may be at an increased risk for comorbid cardiac conditions. #ChronicSpontaneousUrticaria #comorbidities #heartdisease https://lnkd.in/gGWt-igP

This review describes dapsone and its diverse applications in dermatology practice. #dermatology #Dapsone #leprosy #openaccess https://lnkd.in/gCC5bewS

This review in BioDrugs highlights the synergistic potential of local therapies and CAR T cell treatment to overcome challenges posed by solid tumors and provides an overview of current research combining these two strategies. #carttherapy #SolidTumors #combinationtherapy https://lnkd.in/ggJ5Uju6

Read the top downloaded papers in BioDrugs in 2024. A special thanks to the contributing authors, including Achim Prof. Dr. Aigner, William Strohl, Sivan Cohen, Serge Muyldermans, Beate Bittner, Allison Keeler, Danielle Stanisic, Rakesh N. Veedu https://lnkd.in/gaB_hcF2

Alexa B. Kimball, and colleagues review the current research on targeted therapies for hidradenitis suppurativa, including FDA-approved biologics and therapies in phase III and II trials. #hidradenitisSuppurativa #biologics #JAKinhibitors https://lnkd.in/g-SNJNhY

This AdisInsight report in BioDrugs summarizes the milestones in the development of insulin icodec leading to this first approval for diabetes mellitus. https://lnkd.in/g8gCXc3q #insulin #diabetes #firstapproval