LGC LoGiCal’s Post

HSA’s Analytical Toxicology Laboratory-Drug Abuse Testing (ATL-DAT) is delighted to announce that we recently published our in-house developed method for multi-drug analysis in hair using gas chromatography-tandem mass spectrometry (GC-MS/MS). The paper authored by HuiFen Hannah Zhang, Hooi Yan Moy, and Dr Chi Pang Lui, and published in the Drug Testing and Analysis journal details our improved hair analysis method that offers: - Simultaneous analysis of multiple drugs which include opiates, amphetamines, ketamine and cocaine, via a comprehensive procedure involving hair decontamination, pulverization, clean-up using supported-liquid extraction (SLE) and a two-step derivatisation process; - Enhanced efficiency through using semi-automated sample preparation procedure; - Key benefits including faster analysis turnaround time and reduced amount of hair sample required for analysis. This represents a significant step forward as this enhanced method will allow HSA to better support our partner agencies in their ongoing efforts to help keep Singapore drug-free.   The full paper can be found here: https://lnkd.in/gyEThg3F. #ForensicScience #Innovation #ResearchAndDevelopment

Novel Psychoactive Substances (NPS) are a diverse group of synthetic substances created to mimic the effects of prescription or illicit drugs that are often used non-medically. There are various classes of NPS including designer opioids, designer benzodiazepines, synthetic cannabinoids, synthetic stimulants, hallucinogens/dissociatives, and others. Once an NPS has been deemed a controlled substance, often new or modified non-regulated NPS appear. This remains a challenge for regulatory and enforcement agencies, monitoring institutions, clinical and toxicology laboratories, as well as healthcare providers. In this month's clinical update, we will evaluate changes observed in the prevalence of NPS detected at Aegis in 2023. Clinical Update: https://lnkd.in/gtVdjqxB #AegisLabs #NPS #Synthetic #Opioids #Overdose #Stimulants #Cannabinoids #Illicit #Fentanyl #Xylazine #Benzodiazepines #Hallucinogens #OnePillCanKill

U of A toxicology expert works to unravel the mysteries of free radicals and adverse drug reactions. Dr. Arno Siraki and his lab also perform pre-clinical testing for potential new drugs. Learn more about Siraki's research: https://lnkd.in/gJyB4pJY

This would be very helpful in ensuring safe supply for people who use drugs. In some countries, testing drugs using reagents can also be done. It might need some training but it’s already being used by non-professionals as well! #TestDrugsNotPeople #HarmReduction

Drug-Impaired Driving: The Contribution of Emerging and Undertested Drugs by the National Institute of Justice. "In 2007, the National Safety Council (NSC) introduced testing scope and cutoff standardization for impaired driving cases and traffic fatalities to improve testing consistency. Since 2013, it has recommended that forensic toxicology labs regularly test blood for 35 of the most often encountered drugs and metabolites. Referred to as Tier I drugs (Figure below), they are now included as a testing standard in many forensic toxicology labs.[3] Furthermore, these compounds can be detected and confirmed with commonly used analytical instrumentation." #DUI #DWI #forsenic #toxicology #science Kevin Schug Jonathan Thacker Melissa Giguere Zacariah Hildenbrand Ph.D. Edward Westerfield https://lnkd.in/g3Faw63N

I recently attended a two-hour masterclass on "Anticancer Therapy Toxicology"💊🧬 conducted by CliMed Academy, an initiative of CliMed Research Solutions, on July 24, 2024. The session covered essential aspects of anticancer drug toxicities, including: 👉Toxicities of Anticancer Drugs: Understanding the various toxicities associated with anticancer therapies. 👉Grading and Assessment of Toxicities: Learning methods to grade and assess these toxicities effectively. 👉General Management: Exploring strategies for managing these toxicities in clinical practice. 👉Case Discussions: Engaging in practical case discussions to apply theoretical knowledge. This masterclass has significantly enhanced my knowledge and skills in managing anticancer therapy toxicities, contributing to my professional development. #Anticancertoxicology #CliMedResearchSolutions #Curioinstitute #CliMedAcademy

This new approach to the traditional solid phase extraction of therapeutic and abused drugs cuts down on sample volume, standard costs, and time. XTR tips have been used for extraction and cleanup methods for clinical applications and forensic toxicology. CLICK HERE: https://lnkd.in/ekqYAmxk

Catch up on our first three episodes of Tox Chat Box here... 💡Ep 1: Identify unknowns with confidence https://sciex.li/4eqpx4 💡Ep 2: Uncover emerging drugs with NPS Discovery https://sciex.li/p61dty 💡Ep 3: Streamline toxicology screening with software https://sciex.li/ldnmpr #ToxChatBox #ForensicToxicology #ForensicAnalysis #NPS

We are excited to present the experts who will lead our session on "Understanding Toxicity and Improving Management" with the following key topics: - Suicide powders: Do they represent a threat to our society? - Toxicology in the Frail Elderly - Should we intubate all poisoned patients with Glasgow coma score of less than 8? - Preventing Injuries from Chemical Splashes Join us on February 23-26 in Muscat, Oman, to gain insights from these distinguished speakers and enhance your knowledge in advanced toxicology. 🔗 Learn More About the Program: www.menatoxconference.com #MENATOX2025 #ClinicalToxicology #Muscat

Forensic Toxicology labs are vital in detecting drugs and poisons in biological samples. Effective sample preparation is essential for accurate results, especially with complex matrices. Discover how Waters Corporation' Oasis SPE products can simplify sample clean-up and boost sensitivity. Join the webinar to learn more! #ForensicScience #Toxicology #LabEfficiency #Webinar