Health Sciences Authority’s Post

U of A toxicology expert works to unravel the mysteries of free radicals and adverse drug reactions. Dr. Arno Siraki and his lab also perform pre-clinical testing for potential new drugs. Learn more about Siraki's research: https://lnkd.in/gJyB4pJY

Drug-Impaired Driving: The Contribution of Emerging and Undertested Drugs by the National Institute of Justice. "In 2007, the National Safety Council (NSC) introduced testing scope and cutoff standardization for impaired driving cases and traffic fatalities to improve testing consistency. Since 2013, it has recommended that forensic toxicology labs regularly test blood for 35 of the most often encountered drugs and metabolites. Referred to as Tier I drugs (Figure below), they are now included as a testing standard in many forensic toxicology labs.[3] Furthermore, these compounds can be detected and confirmed with commonly used analytical instrumentation." #DUI #DWI #forsenic #toxicology #science Kevin Schug Jonathan Thacker Melissa Giguere Zacariah Hildenbrand Ph.D. Edward Westerfield https://lnkd.in/g3Faw63N

New publication from our lab regarding Bromazolam detection in postmortem toxicology cases in Indiana in 2023. https://lnkd.in/gnzFemBu

Difficulties associated with the interpretation of postmortem toxicology https://lnkd.in/d4i_S-e7

Stay up to date with the ever-changing field of forensic toxicology: 📊Targeted and non-targeted drug screening using accurate mass 📊Novel psychoactive substances analysis 📊Targeted quantitative drug testing Learn more here: https://sciex.li/29v958 #ForensicToxicology #ForensicTesting #ForensicAnalysis #MassSpec

#ForensicFriday: Synthetic opioids are making illicit drug use more dangerous than ever, according to Britain’s National Crime Agency. “With nitazenes you can absolutely die the very first time you take it and with nitazenes you very often don’t know you are taking it,” said the director general of the NCA, Graeme Biggar. Nitazenes are often contained in synthetic cannabinoid receptor agonists and benzodiazepines, or taken along with other drugs such as heroin, increasing the risk to a wide range of drug users. 💻Explore our broad portfolio of reference and research materials to support forensic examinations and clinical toxicology at https://okt.to/VmBXWG 📰 Read the news at https://okt.to/GKSYyR #SyntheticOpioids #IlliciDrugs #nitazenes

Stay ahead in forensic toxicology! Learn advanced UPLC-MS/MS methods for rapid and comprehensive benzodiazepine analysis in urine and post-mortem samples. Discover the latest advancements and hear from industry experts. Join us for a two-part webinar entitled "Uncharted Territory: Innovative Approaches to Novel Benzodiazepine Analysis in Toxicology"!

Read our article on the increase in occupational intoxications.

For bioinformatitian working in the field of computational toxicolgy / with toxicology data / interested in AOP's + FAIRification of toxicological research output. We like to draw your attention to the ELIXIR Webinar: Empowering Toxicology Research - Leveraging ELIXIR Data Solutions. Register here: [https://lnkd.in/eQh8bn2u] Join us on May 2nd from 15-17h CEST for an engaging webinar organized by the ELIXIR Toxicology Community[FAIRification of toxicological research output ]. They will provide insights into how the ELIXIR platforms (Data and Interoperability)[https://lnkd.in/ekmph7da] can change toxicological data management, tackling data challenges faced by large toxicology research consortia like #PARC, #ASPIS and #NSC. This webinar serves as preparation for the free-of charge 1,5-days hands-on workshop entitled "FAIR-ification of Toxicological Research Output: Leveraging ELIXIR Resources" to be held on 28-29 May 2024 in Utrecht, the Netherlands, which is the first in a row of five workshops organized during 2024 -2025 by the Toxicology Community in the context of their first Implementation Study #INTOXICOM. Register here [https://lnkd.in/eQh8bn2u] #INTOXICOM #ELIXIR [https://lnkd.in/eNkiQCek]

𝗧𝗼𝘅𝗶𝗰𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝗽𝗿𝗼𝗳𝗶𝗹𝗶𝗻𝗴 𝘂𝘀𝗶𝗻𝗴 𝙞𝙣 𝙨𝙞𝙡𝙞𝙘𝙤 𝗡𝗔𝗠𝘀 Applying a battery of reliable prediction models handpicked by our #insilico and #toxicology experts, Simply Predict by CEHTRA can provide a time and cost-effective solution to identify structural alerts for a wide range of toxicological endpoints (including #skinsensitisation, #skinirritation #eyeirritation #carcinogenicity #mutagenicity #DART etc.) https://lnkd.in/e6hcPiHW 𝗔 𝘂𝘀𝗲𝗳𝘂𝗹 𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 𝘄𝗵𝗲𝗻: • None or very limited experimental data are available. • Multiple candidate structures are considered in the R&D phase and their toxicity profiles are to be compared. • 𝘐𝘯 𝘷𝘪𝘵𝘳𝘰 test results are inconclusive and 𝘪𝘯 𝘴𝘪𝘭𝘪𝘤𝘰 support is desired as weight of evidence.   𝗛𝗼𝘄 𝘁𝗵𝗶𝘀 𝘄𝗼𝗿𝗸𝘀? • Predictions generated from different models are carefully reviewed by our 𝘪𝘯 𝘴𝘪𝘭𝘪𝘤𝘰 experts. • Structural fragments triggering these alerts and underlying mechanisms are then carefully investigated by our toxicology and chemistry experts. • Methodology applied and all our key conclusions can be provided in a report format to best suit the R&D and regulatory requirements of our clients.   𝗔𝗿𝗲 𝘀𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗮𝗹 𝗮𝗹𝗲𝗿𝘁𝘀 𝘀𝘂𝗳𝗳𝗶𝗰𝗶𝗲𝗻𝘁 𝘁𝗼 𝗿𝗲𝗮𝗰𝗵 𝗰𝗹𝗲𝗮𝗿 𝗰𝗼𝗻𝗰𝗹𝘂𝘀𝗶𝗼𝗻𝘀? • They are a good starting point to understand which toxic effects can be potentially triggered by the chemical in question. Their relevance can be further evaluated: • Running reliable #QSAR models to understand if the findings are coherent from a statistical point of view. • Identifying relevant #Readacross analogues with strong structural and mechanistic similarities to understand if available experimental data on analogues are in line with triggered toxicity alerts.   𝗖𝗮𝗻 𝗦𝗶𝗺𝗽𝗹𝘆 𝗣𝗿𝗲𝗱𝗶𝗰𝘁 𝗽𝗿𝗼𝘃𝗶𝗱𝗲 𝘀𝘂𝗽𝗽𝗼𝗿𝘁 𝘄𝗶𝘁𝗵 𝗤𝗦𝗔𝗥 𝗮𝗻𝗱 𝗥𝗲𝗮𝗱𝗮𝗰𝗿𝗼𝘀𝘀? • Tox profiling, QSAR and Read-Across are the three key elements of our #insilico #NAMs approach and we have access to necessary tools and expertise to deliver reliable results. • We handpick the most appropriate tools, ensuring that they can handle the query chemical within the model’s applicability domain and generate reliable predictions. • Our experts have solid experience to compile reporting formats (including #RAAF, #QPRF) to ensure #regulatorycompliance.   𝗪𝗵𝗶𝗰𝗵 𝗯𝘂𝘀𝗶𝗻𝗲𝘀𝘀 𝘀𝗲𝗰𝘁𝗼𝗿𝘀 𝗮𝗿𝗲 𝗰𝗼𝗻𝗰𝗲𝗿𝗻𝗲𝗱? #REACH, #Cosmetics, #Pharmaceuticals, #MedicalDevices #EndocrineDisruption, #PlantProtection, #NovelFood and #Biocides.   𝗖𝗵𝗲𝗰𝗸 𝗼𝘂𝘁 𝗵𝗼𝘄 𝗼𝘂𝗿 𝗶𝗻 𝘀𝗶𝗹𝗶𝗰𝗼 #consulting 𝗮𝗻𝗱 #training 𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻𝘀 𝗰𝗮𝗻 𝗵𝗲𝗹𝗽 𝘆𝗼𝘂𝗿 𝗯𝘂𝘀𝗶𝗻𝗲𝘀𝘀: https://lnkd.in/e6hcPiHW Clarisse Bavoux, Mathieu Rolland, Pierre-Yves Joyeux, Julien Leghait, Estelle Beltran, Caroline Opitz, Nathalie Hanon, Faizan Sahigara, Stéphane PIERRE