Can DNA sequencing detect organisms contained within a biofilm or intracellular bacterial community? We've recently published another expert interview requested by our community, to answer this and many other questions. In part one, we discussed the following topics with Dr. Nick Parkinson from Systems Biology Laboratory UK c.i.c ● Is it always recommended that a vaginal swab test be conducted alongside a urine test, for female patients? ● Can PCR or NGS tests confirm the presence of biofilms, and is it important to know whether a biofilm is present? ● Are there particular organisms that you see most frequently in cases of recurrent or persistent UTI? ● Given organisms are always present in the urinary tract, how do we know if the organisms identified are causing symptoms? ● Is it possible for known pathogens to live in the bladder microbiome and not cause symptoms? ● Is it possible for ‘good bacteria’ to cause symptoms, and have you seen evidence of this in your research? ● Is there any benefit to testing in between UTI episodes, when symptoms are not present? ● Have you done any testing on probiotics themselves, to see whether they contain what is listed on the label? Watch the full interview on our YouTube channel: https://lnkd.in/drFzbm2K If you're an expert who would like to share insights with our community, we'd love to hear from you. #utitesting #antibioticresistance #recurrentuti #chronicuti #womenshealth #bladdersmatter
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HOPE for the Week: Influence of hypothermic oxygenated machine perfusion on the immunogenicity of donor livers. This abstract presented by Miriam Cortes-Cerisuelo at #ILTS2024 explored how HOPE treatment downregulates ROS transcriptional pathways and influence post-transplant donor-specific CD8+ and Treg cells responses. This provides a mechanistic explanation for the reduced incidence of rejection observed in patients receiving HOPE-treated allografts. #HOPEForTheWeek #LiverTransplantation #MachinePerfusion #TransplantResearch https://lnkd.in/gj8bdhNm
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How does protein modeling using #SwissModel or #AlphaFold influence the #VirtualScreening results of the tick-borne #encephalitis virus? This question was addressed in our recent paper with Felicitas Finke, Fabian Schuhmann and Ilia Solov'yov. The publication in the journal of #MolecularDiversity can be found here: https://lnkd.in/euP53-Wh
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Director of Bioinformatics | Cure Diseases with Data | Author of From Cell Line to Command Line | Data Science | Educator | Cloud Computing | Dana-Farber | MD Anderson | Join 34K followers on Twitter @tangming2005
SAVANA: reliable analysis of somatic structural variants and copy number aberrations in clinical samples using long-read sequencing https://lnkd.in/e6sQSTMY
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Immune hyperactivity is a significant issue in #autoimmune and #inflammatory conditions -- so how can it be reduced? With help from a LUNA-II Automated #CellCounter, researchers tested how ethyl pyruvate affects signaling in #immunogenic dendritic cells. https://ow.ly/x8zJ50SfPgK
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The aim of this study was to develop a #DeepLearning model in order to improve the diagnostic performance of EIC and ASPECTS in acute ischemic stroke, resulting in a better performance from radiologists when assisted by the model. (Weidao Chen et al.) #InsightsIntoImaging 🔗 https://buff.ly/4a2jY4b
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A research study published in the journal 𝘕𝘢𝘵𝘶𝘳𝘦 reports a novel, universal approach to record and understand the transient physical interactions underlying cell biological communications during immune responses. https://lnkd.in/g7WarRHW #medicine #lifescience #biomedicalresearch #immuneresponse
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The convenience, speed, and accuracy of POCT have made it a game-changer in respiratory virus detection. Learn about the key recent trends in an article published by #AnalyticaChimicaActa (https://lnkd.in/dueSeruX) that explores: (1) isothermal nucleic acid amplification (2) molecular diagnostics on paper platforms (3) highly sensitive #immunoassays based on advanced techniques, including the use of alternative sample types such as saliva and exhaled breath If you are looking for innovative master mixes that can work directly on crude saliva samples using LAMP technologies, visit: https://lnkd.in/eEmjbQRk #moleculardiagnostics #pointofcare #isothermalamplification
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Data scientist/Investigator at Novartis Institutes for BioMedical Research (NIBR)
We're excited to share our latest preprint detailing the identification of a novel master regulator in fibrosis, guided by comprehensive multiomics data analysis. This breakthrough expands our understanding of fibrosis pathogenesis. #Fibrosis #Multiomics #Preprint
Our work on identifying a new regulator of fibrosis was just uploaded to Biorxiv (https://lnkd.in/emX_iz7K). It's a really exciting example of how human sample profiling and functional, molecular and mechanistic studies can teach us new aspects of human diseases. Feel free to leave a post or comment on the Biorxiv.
The transcription factor ZNF469 regulates collagen production in liver fibrosis
biorxiv.org
